日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Combined antagonism of Oncostatin M (OSM) and Interleukin 6 (IL-6) provides both anti-fibrotic and anti-inflammatory benefit in pulmonary fibrosis

联合拮抗抑瘤素M(OSM)和白细胞介素6(IL-6)可同时发挥抗纤维化和抗炎作用,用于治疗肺纤维化。

Ratsimandresy, Rojo A; Doran, Emma; Dengler, Hart S; Headland, Sarah E; Wedeles, Christopher J; Guidi, Riccardo; Xu, Daqi; Liu, Jiatong; Shi, Yongchang; Wang, Jianyong; Uttarwar, Salil; Abbas, Alexander R; Sun, Tianhe; DePianto, Daryle J; Morshead, Katrina B; Arron, Joe; Rock, Jason R; Bevers, Jack; Yadav, Rajbharan; Ramalingam, Thirumalai; Gao, Xia; Brightbill, Hans D; Emson, Claire L; Jeet, Surinder; Arlantico, Alexander; Wong, Aaron; Yu, Sherman; Tran, Tiffany Hao; Leong, Laurie; Dohse, Monika; Austin, Cary; Caplazi, Patrick; Panettieri, Reynold A; Koziol-White, Cynthia; Jester, William F; Shaw, Andrey; Avraham, Shimrit; Menon, Hari; Darmanis, Spyros; Modrusan, Zora; Kajihara, Kimberly; Kanamori, Masakazu; Shimada, Hideaki; West, Nathaniel R; Nakamura, Gerald; Vander Heiden, Jason A; Wilson, Mark S

The IL-22-oncostatin M axis promotes intestinal inflammation and tumorigenesis.

IL-22-抑癌素M轴促进肠道炎症和肿瘤发生

Cineus Roodline, Luo Yanjiang, Saliutina Mariia, Manna Subhakankha, Cancino Camila A, Velasco Blázquez Luis, Wang Lifen, Bösel Diana, Abdelrahman Aya, Klementowicz Joanna E, Scherl Alexis, Hainbuch Saskia, Bréart Béatrice, Kwon Gino, Konopka Agata, Guerra Gabriela M, von Coburg Elena, Gerbeth Lorenz, Roels Juliette, Heinrich Frederik, Müller Nils, Durek Pawel, Deigendesch Nikolaus, Ziai James, Hung Jeffrey, Conrad Thomas, Kühl Anja A, Wirtz Stefan, Löhning Max, Keir Mary, Diefenbach Andreas, Mashreghi Mir-Farzin, Siegmund Britta, Schumann Michael, Romagnani Chiara, West Nathaniel R, Hegazy Ahmed N

Engineered IL-18 variants with half-life extension and improved stability for cancer immunotherapy.

经基因工程改造的IL-18变体,具有延长半衰期和提高稳定性,可用于癌症免疫治疗

Bainbridge Travis W, Wang Lifen, Moskalenko Marina, Herrera Robert, Paluch Maciej T, Sun Dawei, Tasneem Kazi, Saini Harpinder, Sadek Manal, Kwong Mandy, Kim Yoon Min, Bhatt Jay M, Tam Christine, Chan Pamela Pui Fung, Ovacik Ayse Meric, Masureel Matthieu, Zhao Yue, Sockolosky Jonathan T, Qu Yan, West Nathaniel R, Bulutoglu Beyza