日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A model-based prion vaccine protects a transgenic mouse line carrying a Gerstmann-Sträussler-Scheinker disease mutation

一种基于模型的朊病毒疫苗能够保护携带格斯特曼-施特劳斯勒-沙因克氏病突变的转基因小鼠品系

Fang, Andrew; Tang, Xinli; Fleming, Madeleine; Tancowny, Brian; Wang, Xiongyao; Wang, YongLiang; Daude, Nathalie; Dorosh, Lyudmyla; Fleck, Shelaine C; Rathod, Vineet; Coustou, Virginie; Cervantes, Silvia A; Velásquez, Camilo Duque; Westaway, David; Aiken, Judd; McKenzie, Debbie; Telling, Glenn; Stepanova, Maria; Saupe, Sven J; Siemer, Ansgar B; Wille, Holger

Expression of progerin enhances disease-related endpoints in a tau seeding reporter cell system.

在tau种子报告细胞系统中,早衰蛋白的表达增强了与疾病相关的终点。

Han Zhuang Zhuang, Kang Sang-Gyun, Gomez-Cardona Erik, Wohlgemuth Serene, Shmeit Klinton, Arce Luis, Safar Jiri G, Julien Olivier, Westaway David

Microbial Composition, Disease Trajectory and Genetic Background in a Slow Onset Model of Frontotemporal Lobar Degeneration

额颞叶变性缓慢发作模型中的微生物组成、疾病轨迹和遗传背景

Daude, Nathalie; Machado, Ivana; Arce, Luis; Yang, Jing; Westaway, David

Prion Protein Endoproteolysis: Cleavage Sites, Mechanisms and Connections to Prion Disease

朊病毒蛋白内切酶水解:切割位点、机制及其与朊病毒病的联系

Castle, Andrew R; Westaway, David

Application of N-Terminal Labeling Methods Provide Novel Insights into Endoproteolysis of the Prion Protein in Vivo.

N端标记方法的应用为体内朊病毒蛋白的内切蛋白水解提供了新的见解

Gomez-Cardona Erik, Eskandari-Sedighi Ghazaleh, Fahlman Richard, Westaway David, Julien Olivier

Beta-endoproteolysis of the cellular prion protein by dipeptidyl peptidase-4 and fibroblast activation protein

二肽基肽酶-4和成纤维细胞活化蛋白对细胞朊病毒蛋白的β-内切蛋白水解作用

Castle, Andrew R; Kang, Sang-Gyun; Eskandari-Sedighi, Ghazaleh; Wohlgemuth, Serene; Nguyen, My-Anh; Drucker, Daniel J; Mulvihill, Erin E; Westaway, David

Prion-like strain effects in tauopathies

tau蛋白病中的朊病毒样毒株效应

Han, Zhuang Zhuang; Kang, Sang-Gyun; Arce, Luis; Westaway, David

Distinct populations of highly potent TAU seed conformers in rapidly progressing Alzheimer's disease

在快速进展的阿尔茨海默病中存在不同的、高活性TAU种子构象体群体

Kim, Chae; Haldiman, Tracy; Kang, Sang-Gyun; Hromadkova, Lenka; Han, Zhuang Zhuang; Chen, Wei; Lissemore, Frances; Lerner, Alan; de Silva, Rohan; Cohen, Mark L; Westaway, David; Safar, Jiri G

Correction to: Diverse, evolving conformer populations drive distinct phenotypes in frontotemporal lobar degeneration caused by the same MAPT‑P301L mutation

更正:由同一 MAPT-P301L 突变引起的额颞叶变性中,多样化的、不断演化的构象异构体群体驱动着不同的表型

Daude, Nathalie; Kim, Chae; Kang, Sang-Gyun; Eskandari-Sedighi, Ghazaleh; Haldiman, Tracy; Yang, Jing; Fleck, Shelaine C; Gomez-Cardona, Erik; Han, Zhuang Zhuang; Borrego-Ecija, Sergi; Wohlgemuth, Serene; Julien, Olivier; Wille, Holger; Molina-Porcel, Laura; Gelpi, Ellen; Safar, Jiri G; Westaway, David

Genetic Depletion of Amylin/Calcitonin Receptors Improves Memory and Learning in Transgenic Alzheimer's Disease Mouse Models

基因敲除胰淀素/降钙素受体可改善转基因阿尔茨海默病小鼠模型的记忆和学习能力

Patel, Aarti; Kimura, Ryoichi; Fu, Wen; Soudy, Rania; MacTavish, David; Westaway, David; Yang, Jing; Davey, Rachel A; Zajac, Jeffrey D; Jhamandas, Jack H