Histone Deacetylase Inhibitor Largazole Deactivates A Subset of Superenchancers and Causes Mitotic Chromosome Mis-alignment by Suppressing SP1 and BRD4
组蛋白去乙酰化酶抑制剂拉格唑通过抑制SP1和BRD4,使一部分超增强子失活并导致有丝分裂染色体错位。
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doi:10.1101/2025.01.29.635612
Sanchez, Gilson J; Liu, Zeyu; Hunter, Samuel; Xu, Quanbin; Westfall, Jessica T V; Wheeler, Graycen E; Toomey, Cathryn; Taatjes, Dylan; Allen, Mary; Dowell, Robin D; Liu, Xuedong