日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Combining a High Dose of Metformin With the SIRT1 Activator, SRT1720, Reduces Life Span in Aged Mice Fed a High-Fat Diet

高剂量二甲双胍与SIRT1激活剂SRT1720联合使用会缩短高脂饮食喂养的老年小鼠的寿命。

Palliyaguru, Dushani L; Minor, Robin K; Mitchell, Sarah J; Palacios, Hector H; Licata, Jordan J; Ward, Theresa M; Abulwerdi, Gelareh; Elliott, Peter; Westphal, Christoph; Ellis, James L; Sinclair, David A; Price, Nathan L; Bernier, Michel; de Cabo, Rafael

Identification of a SIRT1 mutation in a family with type 1 diabetes.

在患有 1 型糖尿病的家族中鉴定出 SIRT1 基因突变

Biason-Lauber Anna, Böni-Schnetzler Marianne, Hubbard Basil P, Bouzakri Karim, Brunner Andrea, Cavelti-Weder Claudia, Keller Cornelia, Meyer-Böni Monika, Meier Daniel T, Brorsson Caroline, Timper Katharina, Leibowitz Gil, Patrignani Andrea, Bruggmann Remy, Boily Gino, Zulewski Henryk, Geier Andreas, Cermak Jennifer M, Elliott Peter, Ellis James L, Westphal Christoph, Knobel Urs, Eloranta Jyrki J, Kerr-Conte Julie, Pattou François, Konrad Daniel, Matter Christian M, Fontana Adriano, Rogler Gerhard, Schlapbach Ralph, Regairaz Camille, Carballido José M, Glaser Benjamin, McBurney Michael W, Pociot Flemming, Sinclair David A, Donath Marc Y

Pharmacokinetics and tolerability of SRT2104, a first-in-class small molecule activator of SIRT1, after single and repeated oral administration in man

SRT2104(一种首创的小分子SIRT1激活剂)在人体单次和重复口服给药后的药代动力学和耐受性研究

Hoffmann, Ethan; Wald, Jeff; Lavu, Siva; Roberts, John; Beaumont, Claire; Haddad, Jon; Elliott, Peter; Westphal, Christoph; Jacobson, Eric

Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase.

SIRT1 去乙酰化酶对内皮细胞 Notch 信号传导的乙酰化依赖性调控

Guarani Virginia, Deflorian Gianluca, Franco Claudio A, Krüger Marcus, Phng Li-Kun, Bentley Katie, Toussaint Louise, Dequiedt Franck, Mostoslavsky Raul, Schmidt Mirko H H, Zimmermann Barbara, Brandes Ralf P, Mione Marina, Westphal Christoph H, Braun Thomas, Zeiher Andreas M, Gerhardt Holger, Dimmeler Stefanie, Potente Michael

SRT1720 improves survival and healthspan of obese mice

SRT1720 可提高肥胖小鼠的存活率和健康寿命

Minor, Robin K; Baur, Joseph A; Gomes, Ana P; Ward, Theresa M; Csiszar, Anna; Mercken, Evi M; Abdelmohsen, Kotb; Shin, Yu-Kyong; Canto, Carles; Scheibye-Knudsen, Morten; Krawczyk, Melissa; Irusta, Pablo M; Martín-Montalvo, Alejandro; Hubbard, Basil P; Zhang, Yongqing; Lehrmann, Elin; White, Alexa A; Price, Nathan L; Swindell, William R; Pearson, Kevin J; Becker, Kevin G; Bohr, Vilhelm A; Gorospe, Myriam; Egan, Josephine M; Talan, Mark I; Auwerx, Johan; Westphal, Christoph H; Ellis, James L; Ungvari, Zoltan; Vlasuk, George P; Elliott, Peter J; Sinclair, David A; de Cabo, Rafael

Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP

SIRT1同源物在禁食依赖性脂质/胆固醇调节因子SREBP抑制中发挥保守作用

Walker, Amy K; Yang, Fajun; Jiang, Karen; Ji, Jun-Yuan; Watts, Jennifer L; Purushotham, Aparna; Boss, Olivier; Hirsch, Michael L; Ribich, Scott; Smith, Jesse J; Israelian, Kristine; Westphal, Christoph H; Rodgers, Joseph T; Shioda, Toshi; Elson, Sarah L; Mulligan, Peter; Najafi-Shoushtari, Hani; Black, Josh C; Thakur, Jitendra K; Kadyk, Lisa C; Whetstine, Johnathan R; Mostoslavsky, Raul; Puigserver, Pere; Li, Xiaoling; Dyson, Nicholas J; Hart, Anne C; Näär, Anders M