日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Large Library Docking for Polypharmacology

用于多药理学的大型库对接

Wu, Yujin; Vigneron, Seth; Braz, Joao; Srinivasan, Karthik; Fink, Elissa A; Huang, Xi-Ping; Xu, Xinyu; Huebner, Harald; Kim, Joseph Y; Wang, Jing; Pfeiffer, Tara; Sakamoto, Kensuke; Radchenko, Dmytro S; Rodriguiz, Ramona M; Moroz, Yurii S; Irwin, John J; Gmeiner, Peter; Billesboelle, Christian; Roth, Bryan L; Basbaum, Allan I; Manglik, Aashish; Wetsel, William C; Shoichet, Brian K

Electrical stimulation of the vagus nerve improves amyloid pathology in delirium superimposed on dementia.

迷走神经电刺激可改善痴呆症合并谵妄中的淀粉样蛋白病理。

Song Chengcheng, Wu Pau Yen, Huffman William J, David-Bercholz Jennifer, Bedolla Alicia, Velagapudi Ravikanth, Njoroge Ann, Rodriguiz Ramona M, Wetsel William C, Rendina Danielle, Bilbo Staci D, Chiang Wesley, Ogu Jessica C, Gelbard Harris A, Yang Ting, Grill Warren M, Terrando Niccolò

Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain.

神经降压素受体 1 的 Arrestin 偏向性变构调节剂可缓解急性和慢性疼痛

Guo Ran, Chen Ouyang, Zhou Yang, Bang Sangsu, Chandra Sharat, Li Yize, Chen Gang, Xie Rou-Gang, He Wei, Xu Jing, Zhou Richard, Song Shaoyong, Person Kelsey L, Moore Madelyn N, Alwin Abigail R, Spasojevic Ivan, Jackson Michael R, Olson Steven H, Caron Marc G, Slosky Lauren M, Wetsel William C, Barak Lawrence S, Ji Ru-Rong

Two doses of Qβ virus like particle vaccines elicit protective antibodies against heroin and fentanyl

两剂Qβ病毒样颗粒疫苗可诱导产生针对海洛因和芬太尼的保护性抗体。

Romano, Isabella G; Johnson-Weaver, Brandi; Core, Susan B; Jamus, Andzoa N; Brackeen, Marcus; Blough, Bruce; Dey, Subhakar; Huang, Yumei; Staats, Herman; Wetsel, William C; Chackerian, Bryce; Frietze, Kathryn M

Virtual Compound Screening for Discovery of Dopamine D1 Receptor Biased Allosteric Modulators

利用虚拟化合物筛选发现多巴胺D1受体偏向性变构调节剂

Zhou, Yang; Wetsel, William C; Olson, Steven H; Barak, Lawrence S

Combination of Haloperidol With UNC9994, β-arrestin-Biased Analog of Aripiprazole, Ameliorates Schizophrenia-Related Phenotypes Induced by NMDAR Deficit in Mice.

氟哌啶醇与 UNC9994(阿立哌唑的β-arrestin偏向类似物)的组合可改善小鼠NMDAR缺陷引起的精神分裂症相关表型

Lipina Tatiana V, Giang Huy, Thacker Jonathan S, Wetsel William C, Caron Marc G, Beaulieu Jean Martin, Salahpour Ali, Ramsey Amy J

A two-dose regimen of Qβ virus-like particle-based vaccines elicit protective antibodies against heroin and fentanyl

基于Qβ病毒样颗粒的疫苗,两剂疗程可诱导产生针对海洛因和芬太尼的保护性抗体。

Romano, Isabella G; Johnson-Weaver, Brandi; Core, Susan B; Jamus, Andzoa N; Brackeen, Marcus; Blough, Bruce; Dey, Subhakar; Huang, Yumei; Staats, Herman; Wetsel, William C; Chackerian, Bryce; Frietze, Kathryn M

Prenatal heroin exposure alters brain morphology and connectivity in adolescent mice

产前接触海洛因会改变青春期小鼠的大脑形态和连接性。

Hornburg, Kathryn J; Slosky, Lauren M; Cofer, Gary; Cook, James; Qi, Yi; Porkka, Fiona; Clark, Nicholas B; Pires, Andrea; Petrella, Jeffrey R; White, Leonard E; Wetsel, William C; Barak, Lawrence; Caron, Marc G; Johnson, G Allan

The G protein biased serotonin 5-HT 2A receptor agonist lisuride exerts anti-depressant drug-like activities in mice

G蛋白偏向性5-羟色胺5-HT2A受体激动剂利舒脲在小鼠体内发挥抗抑郁药物样活性

Pogorelov, Vladimir M; Rodriguiz, Ramona M; Roth, Bryan L; Wetsel, William C

Bespoke library docking for 5-HT2A receptor agonists with antidepressant activity

针对具有抗抑郁活性的5-HT2A受体激动剂的定制化化合物库对接

Anat Levit Kaplan #,Danielle N Confair #,Kuglae Kim #,Ximena Barros-Álvarez #,Ramona M Rodriguiz,Ying Yang,Oh Sang Kweon,Tao Che,John D McCorvy,David N Kamber,James P Phelan,Luan Carvalho Martins,Vladimir M Pogorelov,Jeffrey F DiBerto,Samuel T Slocum,Xi-Ping Huang,Jain Manish Kumar,Michael J Robertson,Ouliana Panova,Alpay B Seven,Autumn Q Wetsel,William C Wetsel,John J Irwin,Georgios Skiniotis,Brian K Shoichet,Bryan L Roth,Jonathan A Ellman