日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Uncoupling histone modification crosstalk by engineering lysine demethylase LSD1.

通过改造赖氨酸去甲基酶 LSD1 来解耦组蛋白修饰串扰

Lee Kwangwoon, Barone Marco, Waterbury Amanda L, Jiang Hanjie, Nam Eunju, DuBois-Coyne Sarah E, Whedon Samuel D, Wang Zhipeng A, Caroli Jonatan, Neal Katherine, Ibeabuchi Brian, Dhoondia Zuzer, Kuroda Mitzi I, Liau Brian B, Beck Samuel, Mattevi Andrea, Cole Philip A

Structural and enzymatic plasticity of SIRT6 deacylase activity.

SIRT6 脱酰酶活性的结构和酶可塑性

Wang Zhipeng A, Markert Jonathan, Whedon Samuel D, Abeywardana Maheeshi Yapa, Sheng Xinlei, Nam Eunju, Lee Kwangwoon, Chen Maggie, Waterbury Amanda, Zhao Yingming, Farnung Lucas, Cole Philip A

Balancing Activation and Repression: CoREST-p300 Antagonism Controls Retinoic Acid-Driven Differentiation in AML.

平衡激活和抑制:CoREST-p300拮抗剂控制视黄酸驱动的AML分化。

Tayari Mina M, Santos Helena Gomes Dos, Dokaneheifard Sadat, Whedon Samuel D, Valencia Monica, Arigela Harikumar, Beckedorff Felipe, Watts Justin M, Cole Philip A, Shiekhattar Ramin

Semisynthetic Approach to the Analysis of Tumor Suppressor PTEN Ubiquitination

利用半合成方法分析肿瘤抑制因子PTEN的泛素化

Iwase, Reina; Dempsey, Daniel R; Whedon, Samuel D; Jiang, Hanjie; Palanski, Brad A; Deng, Bedphiny; Cole, Philip A

KATs off: Biomedical insights from lysine acetyltransferase inhibitors

KATs关闭:赖氨酸乙酰转移酶抑制剂的生物医学见解

Whedon, Samuel D; Cole, Philip A

Histone H2B Deacylation Selectivity: Exploring Chromatin's Dark Matter with an Engineered Sortase

组蛋白H2B脱酰基选择性:利用工程化分选酶探索染色质的暗物质

Wang, Zhipeng A; Whedon, Samuel D; Wu, Mingxuan; Wang, Siyu; Brown, Edward A; Anmangandla, Ananya; Regan, Liam; Lee, Kwangwoon; Du, Jianfeng; Hong, Jun Young; Fairall, Louise; Kay, Taylor; Lin, Hening; Zhao, Yingming; Schwabe, John W R; Cole, Philip A

Distinct biochemical properties of the class I histone deacetylase complexes

I类组蛋白去乙酰化酶复合物的独特生化特性

Lee, Kwangwoon; Whedon, Samuel D; Wang, Zhipeng A; Cole, Philip A

Trimethylation of the R5 Silica-Precipitating Peptide Increases Silica Particle Size by Redirecting Orthosilicate Binding

R5 硅沉淀肽的三甲基化通过改变原硅酸盐结合方式增加硅颗粒尺寸

Buckle, Erika L; Sampath, Janani; Michael, Nina; Whedon, Samuel D; Leonen, Calvin J A; Pfaendtner, Jim; Drobny, Gary P; Chatterjee, Champak

Biological consequences of improving the structural stability of hairpins that have antimicrobial activity

提高具有抗菌活性的发夹结构稳定性所带来的生物学后果

Sivanesam, Kalkena; Kier, Brandon L; Whedon, Samuel D; Chatterjee, Champak; Andersen, Niels H

Hairpin structure stability plays a role in the activity of two antimicrobial peptides

发夹结构的稳定性在两种抗菌肽的活性中发挥作用。

Sivanesam, Kalkena; Kier, Brandon L; Whedon, Samuel D; Chatterjee, Champak; Andersen, Niels H