日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

GLP-1R biased cAMP agonism maintains glycemic control with reduced malaise and emesis in preclinical mammalian models

在临床前哺乳动物模型中,GLP-1R 偏向性 cAMP 激动剂作用可维持血糖控制,并减少不适和呕吐。

Baumer-Harrison, Caitlin; Aldaghma, Danya; White, Alex D; Applebey, Sarah V; Pataro, Allison M; Mohiby, Allaha Z; Alonso, Brandon; Xiao, Allison G; O'Farrell, Libbey S; Qian, Yuewei; Coskun, Tamer; Coghlan, Matthew P; Willard, Francis S; Ai, Minrong; Sloop, Kyle W; Doyle, Robert P; Borner, Tito; De Jonghe, Bart C; Hayes, Matthew R

Drug-Induced Phospholipidosis as an Artifact in Antiviral Drug Repurposing

药物诱导的磷脂沉积症是抗病毒药物再利用中的一种假象

Glenn, Isabella S; Paris, Lu; White, Alex D; Garda, Virginia G; Montano, Mauricio; Khalid, Mir M; Kao, Aimee W; Ott, Melanie; Shoichet, Brian K

Hypophagia and body weight loss by tirzepatide are accompanied by fewer GI adverse events compared to semaglutide in preclinical models.

在临床前模型中,与司美格鲁肽相比,替拉帕肽引起的食欲减退和体重减轻伴随的胃肠道不良事件较少

Borner Tito, Pataro Allison M, Doebley Sarah A, Furst Charles D, White Alex D, Gao Serena X, Chow Angela, Sanchez-Navarro Marcos J, Ghidewon Misgana Y, Halas Julia G, Mohiby Allaha Z, Willard Francis S, Grill Harvey J, Ai Minrong, Samms Ricardo J, Hayes Matthew R, De Jonghe Bart C

Prodrug activation in malaria parasites mediated by an imported erythrocyte esterase, acylpeptide hydrolase (APEH)

疟原虫体内前药的激活是由一种输入的红细胞酯酶——酰基肽水解酶(APEH)介导的。

Sundararaman, Sesh A; Miller, Justin J; Daley, Ellora C; O'Brien, Kelsey A; Kasak, Paulina; Daniels, Abigail M; Edwards, Rachel L; Heidel, Kenneth M; Bague, Darean A; Wilson, Madeleine A; Koelper, Andrew J; Kourtoglou, Elexi C; White, Alex D; August, Sloan A; Apple, Georgia A; Rouamba, Regis W; Durand, Anthony J; Esteb, John J; Muller, Florian L; Johnson, R Jeremy; Hoops, Geoffrey C; Dowd, Cynthia S; Odom John, Audrey R

Membrane Perturbations and Assay Interferences by Ivermectin Explain Its In Vitro SARS-CoV-2 Antiviral Activities and Lack of Translatability

伊维菌素引起的膜扰动和检测干扰解释了其体外抗SARS-CoV-2病毒活性及其缺乏转化性的原因

Eastman, Richard T; Rusinova, Radda; Herold, Karl F; Huang, Xi-Ping; Voss, Ty; White, Alex D; Hemmings, Hugh C Jr; Andersen, Olaf S; Dahlin, Jayme L

Differential Role of Phosphorylation in Glucagon Family Receptor Signaling Revealed by Mass Spectrometry.

质谱分析揭示磷酸化在胰高血糖素家族受体信号传导中的差异性作用

Lamb Ian M, White Alex D, Willard Francis S, Chalmers Michael J, Xiao Junpeng

Deciphering the role of glycosaminoglycans in GPCR signaling

揭示糖胺聚糖在GPCR信号传导中的作用

Savransky, Sofya; White, Alex D; Vilardaga, Jean-Pierre

Molecular Mechanisms of PTH/PTHrP Class B GPCR Signaling and Pharmacological Implications

PTH/PTHrP B类GPCR信号传导的分子机制及其药理学意义

Vilardaga, Jean-Pierre; Clark, Lisa J; White, Alex D; Sutkeviciute, Ieva; Lee, Ji Young; Bahar, Ivet

Biased GPCR signaling by the native parathyroid hormone-related protein 1 to 141 relative to its N-terminal fragment 1 to 36

天然甲状旁腺激素相关蛋白1至141相对于其N端片段1至36的偏向性GPCR信号传导

Peña, Karina A; White, Alex D; Savransky, Sofya; Castillo, Ignacio Portales; Jean-Alphonse, Frédéric G; Gardella, Thomas J; Sutkeviciute, Ieva; Vilardaga, Jean-Pierre

Luminescence-activated nucleotide cyclase regulates spatial and temporal cAMP synthesis

发光激活核苷酸环化酶调节 cAMP 合成的时空分布

Naim, Nyla; White, Alex D; Reece, Jeff M; Wankhede, Mamta; Zhang, Xuefeng; Vilardaga, Jean-Pierre; Altschuler, Daniel L