日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of Coronavirus Main Protease Inhibitors with Enhanced Brain Exposure and Potent Oral Efficacy in SARS-CoV-2 and MERS Infection Models

在SARS-CoV-2和MERS感染模型中发现具有增强脑暴露和强效口服疗效的冠状病毒主要蛋白酶抑制剂

Lizzadro, Luca; Li, Jiapeng; Taha, Taha Y; Degotte, Gilles; Detomasi, Tyler C; Zapatero-Belinchon, Francisco J; Hantz, Eric R; Huang, Sijie; Matsui, Yusuke; Henderson, Will R; McCann, Jack T; Montano, Mauricio; Rosecrans, Julia; Torres Pomares, Daniel F; McGovern, Briana L; Diaz-Tapia, Randy; Benjamin, Jared; Gordon, Mary E; Suazo, Isidora D; Settineri, Nicholas S; Diallo, Amy; Krogan, Nevan J; Shoichet, Brian K; Verba, Kliment A; Albrecht, Randy; García-Sastre, Adolfo; White, Kris M; Ott, Melanie; Craik, Charles S; Renslo, Adam R

Linking biochemical and cellular efficacy of MERS coronavirus main protease inhibitors

关联MERS冠状病毒主蛋白酶抑制剂的生化和细胞功效

La, Van N T; Lahav, Noa; Rodriguez, Mario; Diaz-Tapia, Randy; McGovern, Briana; Benjamin, Jared; Barr, Haim; White, Kris M; Kang, Lulu; Chodera, John D; Minh, David D L

Adaptive multi-epitope targeting and avidity-enhanced nanobody platform for ultrapotent, durable antiviral therapy.

用于超强效、持久抗病毒治疗的自适应多表位靶向和亲和力增强纳米抗体平台

Xiang Yufei, Xu Jialu, McGovern Briana L, Ranzenigo Anna, Huang Wei, Sang Zhe, Shen Juan, Diaz-Tapia Randy, Pham Ngoc Dung, Teunissen Abraham J P, Rodriguez M Luis, Benjamin Jared, Taylor Derek J, van Leent Mandy M T, White Kris M, García-Sastre Adolfo, Zhang Peijun, Shi Yi

A community effort in SARS-CoV-2 drug discovery

社区在SARS-CoV-2药物研发方面的努力

Schimunek, Johannes; Seidl, Philipp; Elez, Katarina; Hempel, Tim; Le, Tuan; Noé, Frank; Olsson, Simon; Raich, Lluís; Winter, Robin; Gokcan, Hatice; Gusev, Filipp; Gutkin, Evgeny M; Isayev, Olexandr; Kurnikova, Maria G; Narangoda, Chamali H; Zubatyuk, Roman; Bosko, Ivan P; Furs, Konstantin V; Karpenko, Anna D; Kornoushenko, Yury V; Shuldau, Mikita; Yushkevich, Artsemi; Benabderrahmane, Mohammed B; Bousquet-Melou, Patrick; Bureau, Ronan; Charton, Beatrice; Cirou, Bertrand C; Gil, Gérard; Allen, William J; Sirimulla, Suman; Watowich, Stanley; Antonopoulos, Nick; Epitropakis, Nikolaos; Krasoulis, Agamemnon; Itsikalis, Vassilis; Theodorakis, Stavros; Kozlovskii, Igor; Maliutin, Anton; Medvedev, Alexander; Popov, Petr; Zaretckii, Mark; Eghbal-Zadeh, Hamid; Halmich, Christina; Hochreiter, Sepp; Mayr, Andreas; Ruch, Peter; Widrich, Michael; Berenger, Francois; Kumar, Ashutosh; Yamanishi, Yoshihiro; Zhang, Kam Y J; Bengio, Emmanuel; Bengio, Yoshua; Jain, Moksh J; Korablyov, Maksym; Liu, Cheng-Hao; Marcou, Gilles; Glaab, Enrico; Barnsley, Kelly; Iyengar, Suhasini M; Ondrechen, Mary Jo; Haupt, V Joachim; Kaiser, Florian; Schroeder, Michael; Pugliese, Luisa; Albani, Simone; Athanasiou, Christina; Beccari, Andrea; Carloni, Paolo; D'Arrigo, Giulia; Gianquinto, Eleonora; Goßen, Jonas; Hanke, Anton; Joseph, Benjamin P; Kokh, Daria B; Kovachka, Sandra; Manelfi, Candida; Mukherjee, Goutam; Muñiz-Chicharro, Abraham; Musiani, Francesco; Nunes-Alves, Ariane; Paiardi, Giulia; Rossetti, Giulia; Sadiq, S Kashif; Spyrakis, Francesca; Talarico, Carmine; Tsengenes, Alexandros; Wade, Rebecca C; Copeland, Conner; Gaiser, Jeremiah; Olson, Daniel R; Roy, Amitava; Venkatraman, Vishwesh; Wheeler, Travis J; Arthanari, Haribabu; Blaschitz, Klara; Cespugli, Marco; Durmaz, Vedat; Fackeldey, Konstantin; Fischer, Patrick D; Gorgulla, Christoph; Gruber, Christian; Gruber, Karl; Hetmann, Michael; Kinney, Jamie E; Padmanabha Das, Krishna M; Pandita, Shreya; Singh, Amit; Steinkellner, Georg; Tesseyre, Guilhem; Wagner, Gerhard; Wang, Zi-Fu; Yust, Ryan J; Druzhilovskiy, Dmitry S; Filimonov, Dmitry A; Pogodin, Pavel V; Poroikov, Vladimir; Rudik, Anastassia V; Stolbov, Leonid A; Veselovsky, Alexander V; De Rosa, Maria; De Simone, Giada; Gulotta, Maria R; Lombino, Jessica; Mekni, Nedra; Perricone, Ugo; Casini, Arturo; Embree, Amanda; Gordon, D Benjamin; Lei, David; Pratt, Katelin; Voigt, Christopher A; Chen, Kuang-Yu; Jacob, Yves; Krischuns, Tim; Lafaye, Pierre; Zettor, Agnès; Rodríguez, M Luis; White, Kris M; Fearon, Daren; Von Delft, Frank; Walsh, Martin A; Horvath, Dragos; Brooks, Charles L 3rd; Falsafi, Babak; Ford, Bryan; García-Sastre, Adolfo; Yup Lee, Sang; Naffakh, Nadia; Varnek, Alexandre; Klambauer, Günter; Hermans, Thomas M

Structures of SARS-CoV-2 N7-methyltransferase with DOT1L and PRMT7 inhibitors provide a platform for new antivirals

SARS-CoV-2 N7-甲基转移酶与DOT1L和PRMT7抑制剂的结构为新型抗病毒药物的研发提供了平台

Kottur, Jithesh; White, Kris M; Rodriguez, M Luis; Rechkoblit, Olga; Quintana-Feliciano, Richard; Nayar, Ahana; García-Sastre, Adolfo; Aggarwal, Aneel K

SARS-CoV-2 Inhibitors Identified by Phenotypic Analysis of a Collection of Viral RNA-Binding Molecules

通过对一系列病毒RNA结合分子进行表型分析,鉴定出SARS-CoV-2抑制剂

Simba-Lahuasi, Alvaro; Cantero-Camacho, Ángel; Rosales, Romel; McGovern, Briana Lynn; Rodríguez, M Luis; Marchán, Vicente; White, Kris M; García-Sastre, Adolfo; Gallego, José

Host-directed therapies against early-lineage SARS-CoV-2 retain efficacy against B.1.1.7 variant

针对早期SARS-CoV-2毒株的宿主导向疗法对B.1.1.7变异株仍然有效

Reuschl, Ann-Kathrin; Thorne, Lucy G; Zuliani-Alvarez, Lorena; Bouhaddou, Mehdi; Obernier, Kirsten; Hiatt, Joseph; Soucheray, Margaret; Turner, Jane; Fabius, Jacqueline M; Nguyen, Gina T; Swaney, Danielle L; Rosales, Romel; White, Kris M; Avilés, Pablo; Kirby, Ilsa T; Melnyk, James E; Shi, Ying; Zhang, Ziyang; Shokat, Kevan M; García-Sastre, Adolfo; Jolly, Clare; Towers, Gregory J; Krogan, Nevan J

Phospholipidosis is a shared mechanism underlying the in vitro antiviral activity of many repurposed drugs against SARS-CoV-2

磷脂沉积症是许多用于治疗SARS-CoV-2病毒感染的药物体外抗病毒活性的共同机制。

Tummino, Tia A; Rezelj, Veronica V; Fischer, Benoit; Fischer, Audrey; O'Meara, Matthew J; Monel, Blandine; Vallet, Thomas; Zhang, Ziyang; Alon, Assaf; O'Donnell, Henry R; Lyu, Jiankun; Schadt, Heiko; White, Kris M; Krogan, Nevan J; Urban, Laszlo; Shokat, Kevan M; Kruse, Andrew C; García-Sastre, Adolfo; Schwartz, Olivier; Moretti, Francesca; Vignuzzi, Marco; Pognan, Francois; Shoichet, Brian K

An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike

一种超强效合成纳米抗体通过稳定非活性刺突蛋白来中和SARS-CoV-2病毒。

Schoof, Michael; Faust, Bryan; Saunders, Reuben A; Sangwan, Smriti; Rezelj, Veronica; Hoppe, Nick; Boone, Morgane; Billesbølle, Christian B; Puchades, Cristina; Azumaya, Caleigh M; Kratochvil, Huong T; Zimanyi, Marcell; Deshpande, Ishan; Liang, Jiahao; Dickinson, Sasha; Nguyen, Henry C; Chio, Cynthia M; Merz, Gregory E; Thompson, Michael C; Diwanji, Devan; Schaefer, Kaitlin; Anand, Aditya A; Dobzinski, Niv; Zha, Beth Shoshana; Simoneau, Camille R; Leon, Kristoffer; White, Kris M; Chio, Un Seng; Gupta, Meghna; Jin, Mingliang; Li, Fei; Liu, Yanxin; Zhang, Kaihua; Bulkley, David; Sun, Ming; Smith, Amber M; Rizo, Alexandrea N; Moss, Frank; Brilot, Axel F; Pourmal, Sergei; Trenker, Raphael; Pospiech, Thomas; Gupta, Sayan; Barsi-Rhyne, Benjamin; Belyy, Vladislav; Barile-Hill, Andrew W; Nock, Silke; Liu, Yuwei; Krogan, Nevan J; Ralston, Corie Y; Swaney, Danielle L; García-Sastre, Adolfo; Ott, Melanie; Vignuzzi, Marco; Walter, Peter; Manglik, Aashish

SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling

SARS-CoV-2 Orf6 劫持 Nup98 以阻断 STAT 核输入并拮抗干扰素信号传导

Miorin, Lisa; Kehrer, Thomas; Sanchez-Aparicio, Maria Teresa; Zhang, Ke; Cohen, Phillip; Patel, Roosheel S; Cupic, Anastasija; Makio, Tadashi; Mei, Menghan; Moreno, Elena; Danziger, Oded; White, Kris M; Rathnasinghe, Raveen; Uccellini, Melissa; Gao, Shengyan; Aydillo, Teresa; Mena, Ignacio; Yin, Xin; Martin-Sancho, Laura; Krogan, Nevan J; Chanda, Sumit K; Schotsaert, Michael; Wozniak, Richard W; Ren, Yi; Rosenberg, Brad R; Fontoura, Beatriz M A; García-Sastre, Adolfo