Whitesell Luke相关文献与解析，生知库 | 链接生命科学的每一步

日期影响因子

Structure-guided optimization of small molecules targeting Yck2 as a strategy to combat Candida albicans

以Yck2为靶点的小分子结构导向优化作为对抗白色念珠菌的策略

期刊:Nature Communications

影响因子:15.7

doi:10.1038/s41467-025-57346-z

Puumala, Emily; Nandakumar, Meganathan; Yiu, Bonnie; Stogios, Peter J; Strickland, Benjamin G; Zarnowski, Robert; Wang, Xiaoyu; Williams, Noelle S; Savchenko, Alexei; Andes, David R; Robbins, Nicole; Whitesell, Luke; Willson, Timothy M; Cowen, Leah E

发表日期：2025

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A cationic amphiphilic drug synergizes with strobilurin fungicides to control fungal-borne plant diseases.

一种阳离子两亲性药物与甲氧基丙烯酸酯类杀菌剂具有协同作用，可控制真菌引起的植物病害

期刊:Cell Chemical Biology

影响因子:7.2

doi:10.1016/j.chembiol.2025.05.008

Laflamme Bradley, Blackman Christopher, Loranger Mackenzie, Trilles Richard, Doytchinova-Weil Kalina, Scully Stephen S, Blackburn J Miles, Kanegesuku Anastasia L G, Roizen Jennifer L, Bengtson Stephen, Brown Lauren E, Porco John A, Yoshioka Keiko, Whitesell Luke, Subramaniam Rajagopal, Robbins Nicole, Cowen Leah E

发表日期：2025

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Chemoproteomic Profiling of C. albicans for Characterization of Antifungal Kinase Inhibitors.

念珠菌化学蛋白质组学分析用于鉴定抗真菌激酶抑制剂

期刊:Journal of Medicinal Chemistry

影响因子:6.8

doi:10.1021/acs.jmedchem.5c00097

Shirley David J, Nandakumar Meganathan, Cabrera Aurora, Yiu Bonnie, Puumala Emily, Liu Zhongle, Robbins Nicole, Whitesell Luke, Smith Jeffrey L, Lyons Scott, Mordant Angie L, Herring Laura E, Graves Lee M, CouÃ±ago Rafael M, Drewry David H, Cowen Leah E, Willson Timothy M

免疫/内分泌

发表日期：2025

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Structure-guided optimization of small molecules targeting the yeast casein kinase, Yck2, as a therapeutic strategy to combat Candida albicans

以酵母酪蛋白激酶Yck2为靶点的小分子结构导向优化，作为对抗白色念珠菌的治疗策略

doi:10.21203/rs.3.rs-5524306/v1

Cowen, Leah; Puumala, Emily; Nandakumar, Meganathan; Yiu, Bonnie; Stogios, Peter; Strickland, Benjamin; Zarnowski, Robert; Wang, Xiaoyu; Williams, Noelle; Savchenko, Alexei; Andes, David; Robbins, Nicole; Whitesell, Luke; Willson, Timothy

发表日期：2025

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Chemoproteomic Profiling of C. albicans for Characterization of Anti-fungal Kinase Inhibitors

利用化学蛋白质组学分析白色念珠菌，以鉴定抗真菌激酶抑制剂

doi:10.1101/2025.01.10.632200

Shirley, David J; Nandakumar, Meganathan; Cabrera, Aurora; Yiu, Bonnie; Puumala, Emily; Liu, Zhongle; Robbins, Nicole; Whitesell, Luke; Smith, Jeffrey L; Lyons, Scott P; Mordant, Angie L; Herring, Laura E; Graves, Lee M; Couñago, Rafael M; Drewry, David H; Cowen, Leah E; Willson, Timothy M

发表日期：2025

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Structure-activity Relationship for Diarylpyrazoles as Inhibitors of the Fungal Kinase Yck2.

二芳基吡唑类化合物作为真菌激酶Yck2抑制剂的构效关系

doi:10.1101/2025.07.12.664496

Shirley David J, Yiu Bonnie, Mancera-Ortiz Ikeer, Stogios Peter J, Liu Zhongle, Robbins Nicole, Whitesell Luke, Cowen Leah E, Drewry David H, Willson Timothy M

发表日期：2025

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Addendum: A small molecule produced by Lactobacillus species blocks Candida albicans filamentation by inhibiting a DYRK1-family kinase

附录：乳杆菌属产生的一种小分子通过抑制DYRK1家族激酶来阻断白色念珠菌的丝状化。

期刊:Nature Communications

影响因子:15.7

doi:10.1038/s41467-024-50740-z

MacAlpine, Jessie; Daniel-Ivad, Martin; Liu, Zhongle; Yano, Junko; Revie, Nicole M; Todd, Robert T; Stogios, Peter J; Sanchez, Hiram; O'Meara, Teresa R; Tompkins, Thomas A; Savchenko, Alexei; Selmecki, Anna; Veri, Amanda O; Andes, David R; Fidel, Paul L Jr; Robbins, Nicole; Nodwell, Justin; Whitesell, Luke; Cowen, Leah E

发表日期：2024

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Reply to: Lactobacillus species do not produce 1-acetyl-β-carboline

回复：乳杆菌属不产生1-乙酰基-β-咔啉

期刊:Nature Communications

影响因子:15.7

doi:10.1038/s41467-024-50684-4

MacAlpine, Jessie; Daniel-Ivad, Martin; Atere, Daniela; Laflamme, Bradley; Robbins, Nicole; Navarre, William W; Nodwell, Justin; Whitesell, Luke; Cowen, Leah E

发表日期：2024

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An HSF1-JMJD6-HSP feedback circuit promotes cell adaptation to proteotoxic stress

HSF1-JMJD6-HSP反馈回路促进细胞适应蛋白毒性应激

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:9.1

doi:10.1073/pnas.2313370121

Alasady, Milad J; Koeva, Martina; Takagishi, Seesha R; Segal, Dmitri; Amici, David R; Smith, Roger S; Ansel, Daniel J; Lindquist, Susan; Whitesell, Luke; Bartom, Elizabeth T; Taipale, Mikko; Mendillo, Marc L

细胞生物学

发表日期：2024

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Allosteric inhibition of tRNA synthetase Gln4 by N-pyrimidinyl-Î²-thiophenylacrylamides exerts highly selective antifungal activity.

N-嘧啶基-β-硫代苯基丙烯酰胺对 tRNA 合成酶 Gln4 的变构抑制作用具有高度选择性的抗真菌活性

期刊:Cell Chemical Biology

影响因子:7.2

doi:10.1016/j.chembiol.2024.01.010

Puumala Emily, Sychantha David, Lach Elizabeth, Reeves Shawn, Nabeela Sunna, Fogal Meea, Nigam AkshatKumar, Johnson Jarrod W, Aspuru-Guzik AlÃ¡n, Shapiro Rebecca S, Uppuluri Priya, Kalyaanamoorthy Subha, Magolan Jakob, Whitesell Luke, Robbins Nicole, Wright Gerard D, Cowen Leah E

发表日期：2024

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