日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Empirical Quantification of Predictive Uncertainty Due to Model Discrepancy by Training with an Ensemble of Experimental Designs: An Application to Ion Channel Kinetics

通过实验设计集合训练对模型差异引起的预测不确定性进行经验量化:以离子通道动力学为例

Shuttleworth, Joseph G; Lei, Chon Lok; Whittaker, Dominic G; Windley, Monique J; Hill, Adam P; Preston, Simon P; Mirams, Gary R

Ion channel model reduction using manifold boundaries

利用流形边界进行离子通道模型简化

Whittaker, Dominic G; Wang, Jiahui; Shuttleworth, Joseph G; Venkateshappa, Ravichandra; Kemp, Jacob M; Claydon, Thomas W; Mirams, Gary R

A Parameter Representing Missing Charge Should Be Considered when Calibrating Action Potential Models

在校准动作电位模型时,应考虑代表缺失电荷的参数。

Barral, Yann-Stanislas H M; Shuttleworth, Joseph G; Clerx, Michael; Whittaker, Dominic G; Wang, Ken; Polonchuk, Liudmila; Gavaghan, David J; Mirams, Gary R

Electrophysiological characterization of the hERG R56Q LQTS variant and targeted rescue by the activator RPR260243

hERG R56Q LQTS 变体的电生理特征及激活剂 RPR260243 的靶向拯救

Kemp, Jacob M; Whittaker, Dominic G; Venkateshappa, Ravichandra; Pang, ZhaoKai; Johal, Raj; Sergeev, Valentine; Tibbits, Glen F; Mirams, Gary R; Claydon, Thomas W

Cardiac TdP risk stratification modelling of anti-infective compounds including chloroquine and hydroxychloroquine.

抗感染药物(包括氯喹和羟氯喹)引起心脏尖端扭转型室性心动过速风险的分层模型

Whittaker Dominic G, Capel Rebecca A, Hendrix Maurice, Chan Xin Hui S, Herring Neil, White Nicholas J, Mirams Gary R, Burton Rebecca-Ann B

Accounting for variability in ion current recordings using a mathematical model of artefacts in voltage-clamp experiments

利用电压钳实验中伪影的数学模型来解释离子电流记录的变异性

Lei, Chon Lok; Clerx, Michael; Whittaker, Dominic G; Gavaghan, David J; de Boer, Teun P; Mirams, Gary R

Considering discrepancy when calibrating a mechanistic electrophysiology model

在校准机制性电生理模型时考虑差异

Lei, Chon Lok; Ghosh, Sanmitra; Whittaker, Dominic G; Aboelkassem, Yasser; Beattie, Kylie A; Cantwell, Chris D; Delhaas, Tammo; Houston, Charles; Novaes, Gustavo Montes; Panfilov, Alexander V; Pathmanathan, Pras; Riabiz, Marina; Dos Santos, Rodrigo Weber; Walmsley, John; Worden, Keith; Mirams, Gary R; Wilkinson, Richard D

Mechanistic Insights Into the Reduced Pacemaking Rate of the Rabbit Sinoatrial Node During Postnatal Development: A Simulation Study

兔窦房结在出生后发育过程中起搏频率降低的机制研究:一项模拟研究

Alghamdi, Azzah M; Testrow, Craig P; Whittaker, Dominic G; Boyett, Mark R; Hancox, Jules C; Zhang, Henggui

Calibration of ionic and cellular cardiac electrophysiology models

离子和细胞心脏电生理模型的校准

Whittaker, Dominic G; Clerx, Michael; Lei, Chon Lok; Christini, David J; Mirams, Gary R

Effects of Heart Rate and Ventricular Wall Thickness on Non-invasive Mapping: An in silico Study

心率和心室壁厚度对无创标测的影响:一项计算机模拟研究

Perez Alday, Erick Andres; Whittaker, Dominic G; Benson, Alan P; Colman, Michael A