日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Human genetics suggests differing causal pathways from HMGCR inhibition to coronary artery disease and type 2 diabetes

人类遗传学表明,HMGCR抑制与冠状动脉疾病和2型糖尿病之间存在不同的因果通路。

Hwang, Seongwon; Karhunen, Ville; Patel, Ashish; Lockhart, Sam M; Carter, Paul; Whittaker, John C; Burgess, Stephen

Leveraging large-scale biobanks for therapeutic target discovery

利用大规模生物样本库发现治疗靶点

Ferolito, Brian R; Dashti, Hesam; Giambartolomei, Claudia; Peloso, Gina M; Golden, Daniel J; Gravel-Pucillo, Kai; Rasooly, Danielle; Horimoto, Andrea R V R; Matty, Rachael; Gaziano, Liam; Liu, Yi; Smit, Ines A; Zdrazil, Barbara; Tsepilov, Yakov; Costa, Lauren; Kosik, Nicole; Huffman, Jennifer E; Tartaglia, Gian Gaetano; Bini, Giorgio; Proietti, Gabriele; Ioannidis, Harris; Karim, Mohd A; Hunter, Fiona; Hemani, Gibran; Butterworth, Adam S; Di Angelantonio, Emanuele; Langenberg, Claudia; Ghoussaini, Maya; Leach, Andrew R; Liao, Katherine P; Damrauer, Scott; Selva, Luis E; Whitbourne, Stacey; Tsao, Philip S; Moser, Jennifer; Gaunt, Tom; Cai, Tianxi; Whittaker, John C; Casas, Juan P; Muralidhar, Sumitra; Gaziano, J Michael; Cho, Kelly; Pereira, Alexandre C

A computational framework for defining and validating reproducible phenotyping algorithms of 313 diseases in the UK Biobank

用于定义和验证英国生物银行中313种疾病可重复表型分析算法的计算框架

Torralbo, Ana; Davitte, Jonathan M; Croteau-Chonka, Damien C; Ytsma, Cai; Tomlinson, Chris; Fitzpatrick, Natalie K; Chung, Sheng-Chia; Fatemifar, Ghazaleh; Cortes, Adrian S; Richardson, Tom G; Barclay, Matthew; Carrasco-Zanini, Julia; Finan, Chris; Hemingway, Harry; Hingorani, Aroon D; Kuan, Valerie; Langenberg, Claudia; Lyratzopoulos, Georgios; Lumbers, R Thomas; Pietzner, Maik; Shah, Anoop D; Thygesen, Johan H; Zelenka, Natalie; Whittaker, John C; Ehm, Margaret G; Denaxas, Spiros

Using genetic association data to guide drug discovery and development: Review of methods and applications

利用遗传关联数据指导药物发现和开发:方法和应用综述

Burgess, Stephen; Mason, Amy M; Grant, Andrew J; Slob, Eric A W; Gkatzionis, Apostolos; Zuber, Verena; Patel, Ashish; Tian, Haodong; Liu, Cunhao; Haynes, William G; Hovingh, G Kees; Knudsen, Lotte Bjerre; Whittaker, John C; Gill, Dipender

New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

新的肺功能基因信号揭示了不同种族人群中与慢性阻塞性肺疾病相关的通路

Shrine, Nick; Guyatt, Anna L; Erzurumluoglu, A Mesut; Jackson, Victoria E; Hobbs, Brian D; Melbourne, Carl A; Batini, Chiara; Fawcett, Katherine A; Song, Kijoung; Sakornsakolpat, Phuwanat; Li, Xingnan; Boxall, Ruth; Reeve, Nicola F; Obeidat, Ma'en; Zhao, Jing Hua; Wielscher, Matthias; Weiss, Stefan; Kentistou, Katherine A; Cook, James P; Sun, Benjamin B; Zhou, Jian; Hui, Jennie; Karrasch, Stefan; Imboden, Medea; Harris, Sarah E; Marten, Jonathan; Enroth, Stefan; Kerr, Shona M; Surakka, Ida; Vitart, Veronique; Lehtimäki, Terho; Allen, Richard J; Bakke, Per S; Beaty, Terri H; Bleecker, Eugene R; Bossé, Yohan; Brandsma, Corry-Anke; Chen, Zhengming; Crapo, James D; Danesh, John; DeMeo, Dawn L; Dudbridge, Frank; Ewert, Ralf; Gieger, Christian; Gulsvik, Amund; Hansell, Anna L; Hao, Ke; Hoffman, Joshua D; Hokanson, John E; Homuth, Georg; Joshi, Peter K; Joubert, Philippe; Langenberg, Claudia; Li, Xuan; Li, Liming; Lin, Kuang; Lind, Lars; Locantore, Nicholas; Luan, Jian'an; Mahajan, Anubha; Maranville, Joseph C; Murray, Alison; Nickle, David C; Packer, Richard; Parker, Margaret M; Paynton, Megan L; Porteous, David J; Prokopenko, Dmitry; Qiao, Dandi; Rawal, Rajesh; Runz, Heiko; Sayers, Ian; Sin, Don D; Smith, Blair H; Soler Artigas, María; Sparrow, David; Tal-Singer, Ruth; Timmers, Paul R H J; Van den Berge, Maarten; Whittaker, John C; Woodruff, Prescott G; Yerges-Armstrong, Laura M; Troyanskaya, Olga G; Raitakari, Olli T; Kähönen, Mika; Polašek, Ozren; Gyllensten, Ulf; Rudan, Igor; Deary, Ian J; Probst-Hensch, Nicole M; Schulz, Holger; James, Alan L; Wilson, James F; Stubbe, Beate; Zeggini, Eleftheria; Jarvelin, Marjo-Riitta; Wareham, Nick; Silverman, Edwin K; Hayward, Caroline; Morris, Andrew P; Butterworth, Adam S; Scott, Robert A; Walters, Robin G; Meyers, Deborah A; Cho, Michael H; Strachan, David P; Hall, Ian P; Tobin, Martin D; Wain, Louise V

Polymorphisms in Natural Killer Cell Receptor Protein 2D (NKG2D) as a Risk Factor for Cholangiocarcinoma

自然杀伤细胞受体蛋白2D (NKG2D) 多态性是胆管癌的危险因素

Wadsworth, Christopher A; Dixon, Peter H; Taylor-Robinson, Simon; Kim, Jin U; Zabron, Abigail A; Wong, Jason H; Chapman, Michael H; McKay, Siobhan C; Spalding, Duncan R; Wasan, Harpreet S; Pereira, Steve P; Thomas, Howard C; Whittaker, John C; Williamson, Catherine; Khan, Shahid A

Plasma urate concentration and risk of coronary heart disease: a Mendelian randomisation analysis

血浆尿酸浓度与冠心病风险:一项孟德尔随机化分析

White, Jon; Sofat, Reecha; Hemani, Gibran; Shah, Tina; Engmann, Jorgen; Dale, Caroline; Shah, Sonia; Kruger, Felix A; Giambartolomei, Claudia; Swerdlow, Daniel I; Palmer, Tom; McLachlan, Stela; Langenberg, Claudia; Zabaneh, Delilah; Lovering, Ruth; Cavadino, Alana; Jefferis, Barbara; Finan, Chris; Wong, Andrew; Amuzu, Antoinette; Ong, Ken; Gaunt, Tom R; Warren, Helen; Davies, Teri-Louise; Drenos, Fotios; Cooper, Jackie; Ebrahim, Shah; Lawlor, Debbie A; Talmud, Philippa J; Humphries, Steve E; Power, Christine; Hypponen, Elina; Richards, Marcus; Hardy, Rebecca; Kuh, Diana; Wareham, Nicholas; Ben-Shlomo, Yoav; Day, Ian N; Whincup, Peter; Morris, Richard; Strachan, Mark W J; Price, Jacqueline; Kumari, Meena; Kivimaki, Mika; Plagnol, Vincent; Whittaker, John C; Smith, George Davey; Dudbridge, Frank; Casas, Juan P; Holmes, Michael V; Hingorani, Aroon D

Selecting instruments for Mendelian randomization in the wake of genome-wide association studies

在全基因组关联研究之后选择孟德尔随机化工具

Swerdlow, Daniel I; Kuchenbaecker, Karoline B; Shah, Sonia; Sofat, Reecha; Holmes, Michael V; White, Jon; Mindell, Jennifer S; Kivimaki, Mika; Brunner, Eric J; Whittaker, John C; Casas, Juan P; Hingorani, Aroon D

HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials

HMG-辅酶A还原酶抑制、2型糖尿病和体重:来自基因分析和随机试验的证据

Swerdlow, Daniel I; Preiss, David; Kuchenbaecker, Karoline B; Holmes, Michael V; Engmann, Jorgen E L; Shah, Tina; Sofat, Reecha; Stender, Stefan; Johnson, Paul C D; Scott, Robert A; Leusink, Maarten; Verweij, Niek; Sharp, Stephen J; Guo, Yiran; Giambartolomei, Claudia; Chung, Christina; Peasey, Anne; Amuzu, Antoinette; Li, KaWah; Palmen, Jutta; Howard, Philip; Cooper, Jackie A; Drenos, Fotios; Li, Yun R; Lowe, Gordon; Gallacher, John; Stewart, Marlene C W; Tzoulaki, Ioanna; Buxbaum, Sarah G; van der A, Daphne L; Forouhi, Nita G; Onland-Moret, N Charlotte; van der Schouw, Yvonne T; Schnabel, Renate B; Hubacek, Jaroslav A; Kubinova, Ruzena; Baceviciene, Migle; Tamosiunas, Abdonas; Pajak, Andrzej; Topor-Madry, Roman; Stepaniak, Urszula; Malyutina, Sofia; Baldassarre, Damiano; Sennblad, Bengt; Tremoli, Elena; de Faire, Ulf; Veglia, Fabrizio; Ford, Ian; Jukema, J Wouter; Westendorp, Rudi G J; de Borst, Gert Jan; de Jong, Pim A; Algra, Ale; Spiering, Wilko; Maitland-van der Zee, Anke H; Klungel, Olaf H; de Boer, Anthonius; Doevendans, Pieter A; Eaton, Charles B; Robinson, Jennifer G; Duggan, David; Kjekshus, John; Downs, John R; Gotto, Antonio M; Keech, Anthony C; Marchioli, Roberto; Tognoni, Gianni; Sever, Peter S; Poulter, Neil R; Waters, David D; Pedersen, Terje R; Amarenco, Pierre; Nakamura, Haruo; McMurray, John J V; Lewsey, James D; Chasman, Daniel I; Ridker, Paul M; Maggioni, Aldo P; Tavazzi, Luigi; Ray, Kausik K; Seshasai, Sreenivasa Rao Kondapally; Manson, JoAnn E; Price, Jackie F; Whincup, Peter H; Morris, Richard W; Lawlor, Debbie A; Smith, George Davey; Ben-Shlomo, Yoav; Schreiner, Pamela J; Fornage, Myriam; Siscovick, David S; Cushman, Mary; Kumari, Meena; Wareham, Nick J; Verschuren, W M Monique; Redline, Susan; Patel, Sanjay R; Whittaker, John C; Hamsten, Anders; Delaney, Joseph A; Dale, Caroline; Gaunt, Tom R; Wong, Andrew; Kuh, Diana; Hardy, Rebecca; Kathiresan, Sekar; Castillo, Berta A; van der Harst, Pim; Brunner, Eric J; Tybjaerg-Hansen, Anne; Marmot, Michael G; Krauss, Ronald M; Tsai, Michael; Coresh, Josef; Hoogeveen, Ronald C; Psaty, Bruce M; Lange, Leslie A; Hakonarson, Hakon; Dudbridge, Frank; Humphries, Steve E; Talmud, Philippa J; Kivimäki, Mika; Timpson, Nicholas J; Langenberg, Claudia; Asselbergs, Folkert W; Voevoda, Mikhail; Bobak, Martin; Pikhart, Hynek; Wilson, James G; Reiner, Alex P; Keating, Brendan J; Hingorani, Aroon D; Sattar, Naveed

Refinement of variant selection for the LDL cholesterol genetic risk score in the diagnosis of the polygenic form of clinical familial hypercholesterolemia and replication in samples from 6 countries

改进低密度脂蛋白胆固醇遗传风险评分的变异选择方法,用于诊断多基因型临床家族性高胆固醇血症,并在来自6个国家的样本中进行验证

Futema, Marta; Shah, Sonia; Cooper, Jackie A; Li, KaWah; Whittall, Ros A; Sharifi, Mahtab; Goldberg, Olivia; Drogari, Euridiki; Mollaki, Vasiliki; Wiegman, Albert; Defesche, Joep; D'Agostino, Maria N; D'Angelo, Antonietta; Rubba, Paolo; Fortunato, Giuliana; Waluś-Miarka, Małgorzata; Hegele, Robert A; Aderayo Bamimore, Mary; Durst, Ronen; Leitersdorf, Eran; Mulder, Monique T; Roeters van Lennep, Jeanine E; Sijbrands, Eric J G; Whittaker, John C; Talmud, Philippa J; Humphries, Steve E