日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Precision fragment addition: domain-specific DeepFrag2 models for smarter lead optimization

精准片段添加:针对特定领域的 DeepFrag2 模型,实现更智能的先导化合物优化

García-Jacas, César R; Green, Harrison; Wierbowski, Shayne D; Durrant, Jacob D

A multiscale functional map of somatic mutations in cancer integrating protein structure and network topology

整合蛋白质结构和网络拓扑结构的癌症体细胞突变多尺度功能图谱

Zhang, Yingying; Leung, Alden K; Kang, Jin Joo; Sun, Yu; Wu, Guanxi; Li, Le; Sun, Jiayang; Cheng, Lily; Qiu, Tian; Zhang, Junke; Wierbowski, Shayne D; Gupta, Shagun; Booth, James G; Yu, Haiyuan

Extracellular carriers control lipid-dependent secretion, delivery, and activity of WNT morphogens.

细胞外载体控制 WNT 形态发生素的脂质依赖性分泌、递送和活性

de Almeida Magalhaes Taciani, Liu Jingjing, Chan Charlene, Borges Kleiton Silva, Zhang Jiuchun, Kane Andrew J, Wierbowski Bradley M, Ge Yunhui, Liu Zhiwen, Mannam Prabhath, Zeve Daniel, Weiss Ron, Breault David T, Huang Pengxiang, Salic Adrian

A comprehensive SARS-CoV-2-human protein-protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets

一项全面的SARS-CoV-2-人类蛋白质-蛋白质相互作用组研究揭示了COVID-19的病理生物学和潜在的宿主治疗靶点。

Yadi Zhou # ,Yuan Liu # ,Shagun Gupta # ,Mauricio I Paramo # ,Yuan Hou # ,Chengsheng Mao ,Yuan Luo ,Julius Judd ,Shayne Wierbowski ,Marta Bertolotti ,Mriganka Nerkar ,Lara Jehi ,Nir Drayman ,Vlad Nicolaescu ,Haley Gula ,Savaş Tay ,Glenn Randall ,Peihui Wang ,John T Lis ,Cédric Feschotte ,Serpil C Erzurum ,Feixiong Cheng ,Haiyuan Yu

Structural basis for catalyzed assembly of the Sonic hedgehog-Patched1 signaling complex

Sonic Hedgehog-Patched1信号复合物催化组装的结构基础

Pengxiang Huang, Bradley M Wierbowski, Tengfei Lian, Charlene Chan, Sara García-Linares, Jiansen Jiang, Adrian Salic

Deep learning methods for 3D structural proteome and interactome modeling

用于三维结构蛋白质组和相互作用组建模的深度学习方法

Lee, Dongjin; Xiong, Dapeng; Wierbowski, Shayne; Li, Le; Liang, Siqi; Yu, Haiyuan

A full-proteome, interaction-specific characterization of mutational hotspots across human cancers

人类癌症突变热点的全蛋白质组、相互作用特异性表征

Siwei Chen, Yuan Liu, Yingying Zhang, Shayne D Wierbowski, Steven M Lipkin, Xiaomu Wei, Haiyuan Yu

Hedgehog pathway modulation by glypican 3-conjugated heparan sulfate

磷脂酰肌醇蛋白聚糖 3 结合硫酸肝素对 Hedgehog 通路的调节

Yulu Cherry Liu, Bradley M Wierbowski, Adrian Salic

A comprehensive SARS-CoV-2-human protein-protein interactome network identifies pathobiology and host-targeting therapies for COVID-19

全面的 SARS-CoV-2-人类蛋白质-蛋白质相互作用组网络可确定 COVID-19 的病理生物学和宿主靶向疗法

Yadi Zhou, Yuan Liu, Shagun Gupta, Mauricio I Paramo, Yuan Hou, Chengsheng Mao, Yuan Luo, Julius Judd, Shayne Wierbowski, Marta Bertolotti, Mriganka Nerkar, Lara Jehi, Nir Drayman, Vlad Nicolaescu, Haley Gula, Savaş Tay, Glenn Randall, John T Lis, Cédric Feschotte, Serpil C Erzurum, Feixiong Cheng, 

A 3D structural SARS-CoV-2-human interactome to explore genetic and drug perturbations

SARS-CoV-2-人相互作用组三维结构图,用于探索基因和药物干扰

Shayne D Wierbowski, Siqi Liang, Yuan Liu, You Chen, Shagun Gupta, Nicole M Andre, Steven M Lipkin, Gary R Whittaker, Haiyuan Yu