日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Hypertrophic cardiomyopathy dysfunction mimicked in human engineered heart tissue and improved by sodium-glucose cotransporter 2 inhibitors

肥厚型心肌病功能障碍在人造心脏组织中得到模拟,并可通过钠-葡萄糖协同转运蛋白2抑制剂得到改善

Wijnker, Paul J M; Dinani, Rafeeh; van der Laan, Nico C; Algül, Sila; Knollmann, Bjorn C; Verkerk, Arie O; Remme, Carol Ann; Zuurbier, Coert J; Kuster, Diederik W D; van der Velden, Jolanda

Hypertrophic Cardiomyopathy: A Vicious Cycle Triggered by Sarcomere Mutations and Secondary Disease Hits

肥厚型心肌病:由肌节突变和继发性疾病打击引发的恶性循环

Wijnker, Paul J M; Sequeira, Vasco; Kuster, Diederik W D; Velden, Jolanda van der

The homozygous K280N troponin T mutation alters cross-bridge kinetics and energetics in human HCM

纯合子K280N肌钙蛋白T突变会改变人类肥厚型心肌病(HCM)中的横桥动力学和能量学。

Piroddi, Nicoletta; Witjas-Paalberends, E Rosalie; Ferrara, Claudia; Ferrantini, Cecilia; Vitale, Giulia; Scellini, Beatrice; Wijnker, Paul J M; Sequiera, Vasco; Dooijes, Dennis; Dos Remedios, Cristobal; Schlossarek, Saskia; Leung, Man Ching; Messer, Andrew; Ward, Douglas G; Biggeri, Annibale; Tesi, Chiara; Carrier, Lucie; Redwood, Charles S; Marston, Steven B; van der Velden, Jolanda; Poggesi, Corrado

A novel phosphorylation site, Serine 199, in the C-terminus of cardiac troponin I regulates calcium sensitivity and susceptibility to calpain-induced proteolysis.

心肌肌钙蛋白 I C 末端的丝氨酸 199 是一种新的磷酸化位点,它调节钙敏感性和对钙蛋白酶诱导的蛋白水解的敏感性

Wijnker Paul J M, Li Yuejin, Zhang Pingbo, Foster D Brian, dos Remedios Cris, Van Eyk Jennifer E, Stienen Ger J M, Murphy Anne M, van der Velden Jolanda

Length-dependent activation is modulated by cardiac troponin I bisphosphorylation at Ser23 and Ser24 but not by Thr143 phosphorylation.

长度依赖性激活受心肌肌钙蛋白 I 在 Ser23 和 Ser24 位点的双磷酸化调节,但不受 Thr143 位点磷酸化调节

Wijnker Paul J M, Sequeira Vasco, Foster D Brian, Li Yuejin, Dos Remedios Cristobal G, Murphy Anne M, Stienen Ger J M, van der Velden Jolanda

Phosphorylation of protein kinase C sites Ser42/44 decreases Ca(2+)-sensitivity and blunts enhanced length-dependent activation in response to protein kinase A in human cardiomyocytes.

蛋白激酶 C Ser42/44 位点的磷酸化降低了 Ca(2+) 敏感性,并减弱了人类心肌细胞对蛋白激酶 A 的反应中增强的长度依赖性激活

Wijnker Paul J M, Sequeira Vasco, Witjas-Paalberends E Rosalie, Foster D Brian, dos Remedios Cristobal G, Murphy Anne M, Stienen Ger J M, van der Velden Jolanda

GSK3β phosphorylates newly identified site in the proline-alanine-rich region of cardiac myosin-binding protein C and alters cross-bridge cycling kinetics in human: short communication

GSK3β磷酸化心肌肌球蛋白结合蛋白C富含脯氨酸-丙氨酸区域中新发现的位点,并改变人心肌横桥循环动力学:简讯

Kuster, Diederik W D; Sequeira, Vasco; Najafi, Aref; Boontje, Nicky M; Wijnker, Paul J M; Witjas-Paalberends, E Rosalie; Marston, Steven B; Dos Remedios, Cristobal G; Carrier, Lucie; Demmers, Jeroen A A; Redwood, Charles; Sadayappan, Sakthivel; van der Velden, Jolanda

Perturbed length-dependent activation in human hypertrophic cardiomyopathy with missense sarcomeric gene mutations

错义肌节基因突变导致人类肥厚型心肌病中长度依赖性激活紊乱

Sequeira, Vasco; Wijnker, Paul J M; Nijenkamp, Louise L A M; Kuster, Diederik W D; Najafi, Aref; Witjas-Paalberends, E Rosalie; Regan, Jessica A; Boontje, Nicky; Ten Cate, Folkert J; Germans, Tjeerd; Carrier, Lucie; Sadayappan, Sakthivel; van Slegtenhorst, Marjon A; Zaremba, Ruud; Foster, D Brian; Murphy, Anne M; Poggesi, Corrado; Dos Remedios, Cris; Stienen, Ger J M; Ho, Carolyn Y; Michels, Michelle; van der Velden, Jolanda

Impact of site-specific phosphorylation of protein kinase A sites Ser23 and Ser24 of cardiac troponin I in human cardiomyocytes.

人心肌细胞中肌钙蛋白 I 蛋白激酶 A 位点 Ser23 和 Ser24 位点特异性磷酸化的影响

Wijnker Paul J M, Foster D Brian, Tsao Allison L, Frazier Aisha H, dos Remedios Cristobal G, Murphy Anne M, Stienen Ger J M, van der Velden Jolanda

PKCα-specific phosphorylation of the troponin complex in human myocardium: a functional and proteomics analysis.

PKCα特异性磷酸化人类心肌肌钙蛋白复合物:功能和蛋白质组学分析

Kooij Viola, Zhang Pingbo, Piersma Sander R, Sequeira Vasco, Boontje Nicky M, Wijnker Paul J M, Jiménez Connie R, Jaquet Kornelia E, dos Remedios Cris, Murphy Anne M, Van Eyk Jennifer E, van der Velden Jolanda, Stienen Ger Jm