Optimization of Class I Histone Deacetylase PROTACs Reveals that HDAC1/2 Degradation is Critical to Induce Apoptosis and Cell Arrest in Cancer Cells
类组蛋白去乙酰化酶 PROTAC 的优化表明 HDAC1/2 降解对于诱导癌细胞凋亡和细胞停滞至关重要
期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.1c02179
Joshua P Smalley, India M Baker, Wiktoria A Pytel, Li-Ying Lin, Karen J Bowman, John W R Schwabe, Shaun M Cowley, James T Hodgkinson
信号转导
细胞生物学
肿瘤
表观遗传
肿瘤细胞
Apoptosis
