日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The Use of Nutritional Interventions to Enhance Genomic Stability in Mice and Delay Aging

利用营养干预增强小鼠基因组稳定性并延缓衰老

van Galen, Ivar; Hoeijmakers, Jan H J; Vermeij, Wilbert P

Consistent changes in global gene expression patterns despite strong variation in individual gene expression in the male mouse hippocampus following early life stress

早期生活应激后,雄性小鼠海马体中尽管单个基因表达存在显著差异,但整体基因表达模式却发生了一致的变化。

Sanguino-Gómez, Jeniffer; Buurstede, Jacobus C; Umeoka, Eduardo H L; da Silva Umeoka, Marcia Santos; Gentenaar, Max; Garcia-Cairasco, Norberto; Juruena, Mario F; Vermeij, Wilbert P; Hoeijmakers, Jan H J; Krugers, Harm J; Joëls, Marian; Meijer, Onno C

Correction of pathogenic mitochondrial DNA in patient-derived disease models using mitochondrial base editors

利用线粒体碱基编辑器校正患者来源疾病模型中的致病性线粒体DNA

Indi P Joore ,Sawsan Shehata ,Irena Muffels ,Jose Castro-Alpízar ,Elena Jiménez-Curiel ,Emilia Nagyova ,Natacha Levy ,Ziqin Tang ,Kimberly Smit ,Wilbert P Vermeij ,Richard Rodenburg ,Raymond Schiffelers ,Edward E S Nieuwenhuis ,Peter M van Hasselt ,Sabine A Fuchs ,Martijn A J Koppens

Short-term fasting before living kidney donation has an immune-modulatory effect

活体肾脏捐献前短期禁食具有免疫调节作用

Oudmaijer, Christiaan A J; Komninos, Daphne S J; Ozinga, Rutger A; Smit, Kimberly; Rozendaal, Nina E M; Hoeijmakers, Jan H J; Vermeij, Wilbert P; Aerts, Joachim G J V; IJzermans, Jan N M; Willemsen, Marcella

DDDR-39. Untangling MEK inhibitor resistance in DMG-MAPK using coupled lineage tracing and single cell RNA sequencing

DDDR-39. 利用谱系追踪和单细胞RNA测序技术解析DMG-MAPK中的MEK抑制剂耐药机制

Barnhoorn, Sander; Uittenboogaard, Lieneke M; Jaarsma, Dick; Vermeij, Wilbert P; Tresini, Maria; Weymaere, Michael; Menoni, Hervé; Brandt, Renata M C; de Waard, Monique C; Botter, Sander M; Sarker, Altaf H; Jaspers, Nicolaas G J; van der Horst, Gijsbertus T J; Cooper, Priscilla K; Hoeijmakers, Jan H J; van der Pluijm, Ingrid; Goni, Fernando; Wang, Ding; Suazo, Jianina; Lin, Jasmine; Okeagu, Jasmine; Gamallo‐Lana, Begonia; Mar, Adam; Wisniewski, Thomas; Venua, Rita Mari; Bissig, David Philip; Tokunaga, *Nozomi; Nakamura, Yoki; Hisaoka-Nakahsima, Kazue; Morioka, Norimitsu; Das, Molina; Grabovska, Yura; Tari, Haider; Mackay, Alan; Rogers, Rebecca; Collins, Jared; Song, Jiin; Bevington, Laura; Burford, Anna; Sejdiu, Drenusha; Beroukhim, Rameen; Bandopadhayay, Pratiti; Jones, Chris

High protein intake causes gene-length-dependent transcriptional decline, shortens lifespan and accelerates ageing in progeroid DNA repair-deficient mice.

高蛋白摄入会导致基因长度依赖性转录下降,缩短寿命,并加速早衰症 DNA 修复缺陷小鼠的衰老

van Galen Ivar, Birkisdóttir Maria B, Ozinga Rutger A, Brandt Renata M C, Barnhoorn Sander, Imholz Sandra, van Oostrom Conny T, van der Marel Ricfrid W G N, Smit Kimberly, Rijksen Yvonne M A, Reiling Erwin, van Steeg Harry, Hoeijmakers Jan H J, Dollé Martijn E T, Vermeij Wilbert P

Improved health by combining dietary restriction and promoting muscle growth in DNA repair-deficient progeroid mice

通过饮食限制和促进肌肉生长相结合的方式改善DNA修复缺陷型早衰小鼠的健康状况

Vermeij, Wilbert P; Alyodawi, Khalid; van Galen, Ivar; von der Heide, Jennie L; Birkisdóttir, María B; Van't Sant, Lisanne J; Ozinga, Rutger A; Komninos, Daphne S J; Smit, Kimberly; Rijksen, Yvonne M A; Brandt, Renata M C; Barnhoorn, Sander; Jaarsma, Dick; Vaiyapuri, Sathivel; Ritvos, Olli; Huber, Tobias B; Kretz, Oliver; Patel, Ketan

Metabolomic analysis of dietary-restriction-induced attenuation of sarcopenia in prematurely aging DNA repair-deficient mice

对饮食限制诱导的早衰DNA修复缺陷小鼠肌肉减少症减轻的代谢组学分析

He, Yupeng; Yang, Wei; Huang, Luojiao; Mever, Marlien Admiraal-van; Ramautar, Rawi; Harms, Amy; Rijksen, Yvonne; Brandt, Renata M C; Barnhoorn, Sander; Smit, Kimberly; Jaarsma, Dick; Lindenburg, Peter; Hoeijmakers, Jan H J; Vermeij, Wilbert P; Hankemeier, Thomas

Different Purkinje cell pathologies cause specific patterns of progressive gait ataxia in mice

不同的浦肯野细胞病理会导致小鼠出现特定模式的进行性步态共济失调

Dick Jaarsma, Maria B Birkisdóttir, Randy van Vossen, Demi W G D Oomen, Oussama Akhiyat, Wilbert P Vermeij, Sebastiaan K E Koekkoek, Chris I De Zeeuw, Laurens W J Bosman

Hybrid Molecular and Functional Micro-CT Imaging Reveals Increased Myocardial Apoptosis Preceding Cardiac Failure in Progeroid Ercc1 Mice

混合分子和功能微型CT成像揭示早衰症Ercc1小鼠心力衰竭前心肌细胞凋亡增加

van Thiel, Bibi S; de Boer, Martine; Ridwan, Yanto; de Kleijnen, Marion G J; van Vliet, Nicole; van der Linden, Janette; de Beer, Isa; van Heijningen, Paula M; Vermeij, Wilbert P; Hoeijmakers, Jan H J; Danser, A H Jan; Kanaar, Roland; Duncker, Dirk J; van der Pluijm, Ingrid; Essers, Jeroen