日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Targeting tau in Alzheimer's Disease: rationale, approach and challenges

靶向治疗阿尔茨海默病中的tau蛋白:理论基础、方法和挑战

Aslanyan, Aram; Foiani, Martha S; Giovannucci, Tatiana A; McDade, Eric; Duff, Karen E; Mummery, Catherine J; Schöll, Michael; Wildsmith, Kristin R; Paterson, Ross W

Mechanism of interaction between the transactivation domain of N-myc and the DNA-binding surface of TFIIIC5

N-myc 转录激活结构域与 TFIIIC5 DNA 结合表面相互作用的机制

Leen, Eoin; Yeoh, Sharon; Sahak, Eka; Mitchell, Ellie; Wildsmith, Gemma; Batchelor, Matthew; Calabrese, Antonio N; Büchel, Gabriele; Bayliss, Richard

Etalanetug (E2814) in dominantly inherited Alzheimer's disease: an open-label phase 1b/2 study to assess safety and target engagement in participants with mild to moderate cognitive impairment

Etalanetug (E2814) 在显性遗传性阿尔茨海默病中的应用:一项开放标签的 1b/2 期研究,旨在评估其在轻度至中度认知障碍患者中的安全性和靶点结合情况。

Andreozzi, Erica; Yagi, Takuya; Wildsmith, Kristin; Rawal, Sumit; Horie, Kanta; Boyd, Peter; Takahashi, Eri; Barthélemy, Nicolas R; Aluri, Jagadeesh; Charil, Arnaud; Reilhac, Anthonin; Gordon, Brian A; Flores, Shaney; Verbel, David; Sauter, Nicholas; Benzinger, Tammie L S; McDade, Eric; Mummery, Catherine; Zhou, Jin; Bateman, Randall J; Reyderman, Larisa

Neuro-Dynamic Quantitative Systems Pharmacology (QSP) model describing Alzheimer's disease pathophysiology and treatment effects

描述阿尔茨海默病病理生理学和治疗效果的神经动力学定量系统药理学(QSP)模型

Cao, Youfang; Willis, Brian A; Horie, Kanta; Wildsmith, Kristin R; Koyama, Akihiko; Sachdev, Pallavi; Penner, Natasha; Charil, Arnaud; Irizarry, Michael; Reyderman, Larisa

Combining CSF MTBR-tau243 and plasma pTau217 ratio enhances the prediction of continuous regional tau PET burden in early Alzheimer's disease

脑脊液 MTBR-tau243 与血浆 pTau217 比值相结合,可提高对早期阿尔茨海默病中连续区域 tau PET 负荷的预测能力。

Devanarayan, Viswanath; Horie, Kanta; Wildsmith, Kristin; Doherty, Thomas; Andreozzi, Erica; Charil, Arnaud; Sachdev, Pallavi; Kramer, Lynn D; Dhadda, Shobha; Irizarry, Michael C

Insights into pathophysiology, biomarkers, and therapeutics in tauopathies: Proceedings of the Tau2024 Global Conference

深入了解tau蛋白病的病理生理学、生物标志物和治疗方法:Tau2024全球会议论文集

Frost, Bess; Rowe, James B; Akinyemi, Rufus O; Abisambra, Jose F; Ashton, Nicholas J; Brendel, Matthias; Buée, Luc; Butler, David; Carrillo, Maria C; Chung, Peter; Clelland, Claire D; DeVos, Sarah L; Diaz, Kristophe; Edelmayer, Rebecca M; Elahi, Fanny M; Ellajosyula, Ratnavalli; Ewen, Colin; Fontana, Igor Camargo; Galas, Marie-Christine; Hansson, Oskar; Höglinger, Günter; Horie, Kanta; Ibanez, Agustín; Jacobs, Linde; Maina, Mahmoud B; Malpetti, Maura; McDade, Eric; McEwan, Will; Montoliu-Gaya, Laia; Mummery, Catherine J; Orr, Miranda E; Rohrer, Jonathan D; Rommel, Amy; Sastre, Carlos; Spires-Jones, Tara L; Tee, Boon Lead; Viney, Tim J; Walker, Jamie M; Wegmann, Susanne; Wildsmith, Kristin; Yadav, Ravi; Mahinrad, Simin; Sexton, Claire

Mutational Landscape of Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma and Association with Immune Checkpoint Inhibitor Outcomes

复发/转移性头颈部鳞状细胞癌的突变图谱及其与免疫检查点抑制剂疗效的关系

McCoon, Patricia; Wang, Ying; Lai, Zhongwu; Zhang, Qu; Li, Weimin; Wildsmith, Sophie; Morsli, Nassim; Raja, Rajiv; Holoweckyj, Nicholas; Walker, Jill; de Los Reyes, Melissa; Mesía, Ricard; Licitra, Lisa; Ferris, Robert L; Fayette, Jérôme; Zandberg, Dan P; Siu, Lillian L; Haddad, Robert

Tau biology, biomarkers, and therapeutics

Tau蛋白生物学、生物标志物和治疗方法

Frost, Bess; Kolb, Hartmuth; Algeciras-Schimnich, Alicia; Betthauser, Tobey J; DeVos, Sarah; Edelmayer, Rebecca M; Elwood, Fiona; Fleisher, Adam S; Henley, David; Horie, Kanta; Hyman, Bradley; Kreisl, William Charles; Kulic, Luka; Leuzy, Antoine; Palma, Jose-Alberto; Parmentier-Batteur, Sophie; Patru, Maria-Magdalena; Rabinovici, Gil D; Reyderman, Larisa; Sperling, Reisa A; Van Der Geyten, Serge; Wildsmith, Kristin R; Mahinrad, Simin; Carrillo, Maria C; Weber, Christopher J

The Kocurious case of Noodlococcus: genomic insights into Kocuria rhizophila from characterisation of a laboratory contaminant

好奇的根瘤菌案例:从实验室污染物表征中获得关于根瘤菌的基因组学见解

McCallum, Gregory E; Ho, Siu Fung Stanley; Cummins, Elizabeth A; Wildsmith, Alex J; McInnes, Ross S; Weigel, Christoph; Tong, Lok Yee Sylvia; Quick, Joshua; van Schaik, Willem; Moran, Robert A

Genomic and phenotypic characterization of staphylococci isolated from the skin of non-human primates

从非人灵长类动物皮肤中分离的葡萄球菌的基因组和表型特征

Wildsmith, Caitlin; Barratt, Simon; Kerridge, Frances; Thomas, Jonathan; Negus, David