日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Long-acting lenacapavir protects macaques against intravenous challenge with simian-tropic HIV

长效利那帕韦可保护恒河猴免受猿猴嗜性艾滋病毒的静脉注射攻击

Adrienne E Swanstrom, Robert J Gorelick, Jorden L Welker, Fabian Schmidt, Bing Lu, Kelly Wang, William Rowe, Matthew W Breed, Kristin E Killoran, Joshua A Kramer, Duncan Donohue, James D Roser, Paul D Bieniasz, Theodora Hatziioannou, Cathi Pyle, James A Thomas, Charles M Trubey, Jim Zheng, Wade Blai

Lenacapavir: A Novel, Potent, and Selective First-in-Class Inhibitor of HIV-1 Capsid Function Exhibits Optimal Pharmacokinetic Properties for a Long-Acting Injectable Antiretroviral Agent

雷那卡韦:一种新型、强效、选择性的 HIV-1 衣壳功能抑制剂,具有最佳的长效注射抗逆转录病毒药物药代动力学特性

Raju Subramanian, Jennifer Tang, Jim Zheng, Bing Lu, Kelly Wang, Stephen R Yant, George J Stepan, Andrew Mulato, Helen Yu, Scott Schroeder, Naveed Shaik, Renu Singh, Scott Wolckenhauer, Anne Chester, Winston C Tse, Anna Chiu, Martin Rhee, Tomas Cihlar, William Rowe, Bill J Smith

Long-acting capsid inhibitor protects macaques from repeat SHIV challenges

长效衣壳抑制剂保护恒河猴免受反复 SHIV 攻击

Samuel J Vidal #, Elena Bekerman #, Derek Hansen, Bing Lu, Kelly Wang, Judy Mwangi, William Rowe, Federico Campigotto, Jim Zheng, Darryl Kato, Abishek Chandrashekar, Julia Barrett, Shivani Patel, Huahua Wan, Tochi Anioke, Noe B Mercado, Joseph P Nkolola, Melissa J Ferguson, William J Rinaldi, Christ

Clinical targeting of HIV capsid protein with a long-acting small molecule

长效小分子药物在临床上靶向 HIV 衣壳蛋白

John O Link, Martin S Rhee, Winston C Tse, Jim Zheng, John R Somoza, William Rowe, Rebecca Begley, Anna Chiu, Andrew Mulato, Derek Hansen, Eric Singer, Luong K Tsai, Rujuta A Bam, Chien-Hung Chou, Eda Canales, Gediminas Brizgys, Jennifer R Zhang, Jiayao Li, Michael Graupe, Philip Morganelli, Qi Liu,

Gene-Specific Linear Trends Constrain Transcriptional Variability of the Toll-like Receptor Signaling

基因特异性线性趋势限制了 Toll 样受体信号的转录变异性

James Bagnall, William Rowe, Nissrin Alachkar, James Roberts, Hazel England, Christopher Clark, Mark Platt, Dean A Jackson, Mark Muldoon, Pawel Paszek

Dynamic changes in eIF4F-mRNA interactions revealed by global analyses of environmental stress responses

环境应激反应的整体分析揭示了 eIF4F-mRNA 相互作用的动态变化

Joseph L Costello, Christopher J Kershaw, Lydia M Castelli, David Talavera, William Rowe, Paul F G Sims, Mark P Ashe, Christopher M Grant, Simon J Hubbard, Graham D Pavitt

Signal transduction controls heterogeneous NF-κB dynamics and target gene expression through cytokine-specific refractory states

信号转导通过细胞因子特异性不应期控制异质性 NF-κB 动力学和靶基因表达

Antony Adamson, Christopher Boddington, Polly Downton, William Rowe, James Bagnall, Connie Lam, Apolinar Maya-Mendoza, Lorraine Schmidt, Claire V Harper, David G Spiller, David A Rand, Dean A Jackson, Michael R H White, Pawel Paszek

Global mRNA selection mechanisms for translation initiation

翻译起始的全局 mRNA 选择机制

Joseph Costello, Lydia M Castelli, William Rowe, Christopher J Kershaw, David Talavera, Sarah S Mohammad-Qureshi, Paul F G Sims, Christopher M Grant, Graham D Pavitt, Simon J Hubbard, Mark P Ashe

The 4E-BP Caf20p Mediates Both eIF4E-Dependent and Independent Repression of Translation

4E-BP Caf20p 介导 eIF4E 依赖性和非依赖性的翻译抑制

Lydia M Castelli, David Talavera, Christopher J Kershaw, Sarah S Mohammad-Qureshi, Joseph L Costello, William Rowe, Paul F G Sims, Christopher M Grant, Simon J Hubbard, Mark P Ashe, Graham D Pavitt

Puf3p induces translational repression of genes linked to oxidative stress

Puf3p 诱导与氧化应激相关的基因的翻译抑制

William Rowe, Christopher J Kershaw, Lydia M Castelli, Joseph L Costello, Mark P Ashe, Christopher M Grant, Paul F G Sims, Graham D Pavitt, Simon J Hubbard