日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Loss of ZNRF3/RNF43 unleashes EGFR in cancer

ZNRF3/RNF43 的缺失会激活癌症中的 EGFR。

Yue, Fei; Ku, Amy T; Stevens, Payton D; Michalski, Megan N; Jiang, Weiyu; Tu, Jianghua; Shi, Zhongcheng; Dou, Yongchao; Wang, Yi; Feng, Xin-Hua; Hostetter, Galen; Wu, Xiangwei; Huang, Shixia; Shroyer, Noah F; Zhang, Bing; Williams, Bart O; Liu, Qingyun; Lin, Xia; Li, Yi

The class A repeats of LRP5 are required for normal development of bone, retinal vasculature and mammary gland in vivo

LRP5的A类重复序列是体内骨骼、视网膜血管和乳腺正常发育所必需的。

Diegel, Cassandra R; Michalski, Megan N; Ubels, John L; Wiartalla, Gabrielle Foxa; Lin, Cheng-Mao; Zhong, Zhendong A; McDonald, Mitchell J; Ethen, Nicole J; Brookshire, Madison; Madaj, Zachary B; Xia, Mingxuan; Gavine, Paul R; Antonetti, David A; Williams, Bart O

Local Misalignment Scoring Reveals Spatially Uniform Chondrocyte Disorganization in a Wnt5a-C83S Knock-in Model of Robinow Syndrome

局部错位评分揭示了Wnt5a-C83S敲入Robinow综合征模型中软骨细胞的空间均匀性紊乱

Zhong, Zhendong A; Michalski, Megan N; Diegel, Cassandra R; Christie, Cheryl; Klamer, Zachary; Lanning, Nathan J; Haab, Brian B; Grainger, Stephanie; Williams, Bart O

Inhibiting WNT secretion reduces high bone mass caused by Sost loss-of-function or gain-of-function mutations in Lrp5

抑制WNT分泌可减少由Lrp5基因中Sost功能丧失或功能获得突变引起的高骨量。

Diegel, Cassandra R; Kramer, Ina; Moes, Charles; Foxa, Gabrielle E; McDonald, Mitchell J; Madaj, Zachary B; Guth, Sabine; Liu, Jun; Harris, Jennifer L; Kneissel, Michaela; Williams, Bart O

The Past, Present, and Future of Genetically Engineered Mouse Models for Skeletal Biology

基因工程小鼠骨骼生物学模型的过去、现在和未来

Michalski, Megan N; Williams, Bart O

Structure and function of the retina of low-density lipoprotein receptor-related protein 5 (Lrp5)-deficient rats

低密度脂蛋白受体相关蛋白5(Lrp5)缺陷大鼠视网膜的结构和功能

Ubels, John L; Lin, Cheng-Mao; Antonetti, David A; Diaz-Coranguez, Monica; Diegel, Cassandra R; Williams, Bart O

Regulation of Wnt receptor activity: Implications for therapeutic development in colon cancer

Wnt受体活性调控:对结肠癌治疗发展的意义

Zhong, Zhendong A; Michalski, Megan N; Stevens, Payton D; Sall, Emily A; Williams, Bart O

Co-deletion of Lrp5 and Lrp6 in the skeleton severely diminishes bone gain from sclerostin antibody administration

骨骼中Lrp5和Lrp6的共同缺失会显著降低硬骨素抗体给药后的骨量增加。

Lim, Kyung-Eun; Bullock, Whitney A; Horan, Daniel J; Williams, Bart O; Warman, Matthew L; Robling, Alexander G

LDL receptor-related protein LRP6 senses nutrient levels and regulates Hippo signaling.

LDL受体相关蛋白LRP6感知营养水平并调节Hippo信号传导

Jeong Wonyoung, Kim Soyoung, Lee Ukjin, Zhong Zhendong A, Savitsky Mikhail, Kwon Hyeryun, Kim Jiyoung, Lee Taebok, Cho Jin Won, Williams Bart O, Katanaev Vladimir L, Jho Eek-Hoon

Independent validation of experimental results requires timely and unrestricted access to animal models and reagents

对实验结果进行独立验证需要及时、不受限制地获取动物模型和试剂。

Diegel, Cassandra R; Hann, Steven; Ayturk, Ugur M; Hu, Jennifer C W; Lim, Kyung-Eun; Droscha, Casey J; Madaj, Zachary B; Foxa, Gabrielle E; Izaguirre, Isaac; Robling, Alexander G; Warman, Matthew L; Williams, Bart O