日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Large-scale CSF and plasma proteomics reveal immune, synaptic, and extracellular matrix disruptions across neurodegenerative diseases

大规模脑脊液和血浆蛋白质组学分析揭示了神经退行性疾病中免疫、突触和细胞外基质的紊乱。

Ali, Muhammad; Timsina, Jigyasha; Xu, Ying; Chen, Yike; Gong, Katherine; Western, Daniel; Heo, Gyujin; Liu, Menghan; Budde, John; Pottier, Cyril; Schindler, Suzanne E; Morris, John C; Holtzman, David M; Puerta, Raquel; Cano, Amanda; Boada, Merce; Fernandez, Maria V; Ruiz, Agustin; Aguilar, Miquel; Alvarez, Ignacio; Pastor, Pau; Perlmutter, Joel S; Campbell, Meghan C; Kotzbauer, Paul T; Oh, Hamilton Se-Hwee; Wilson, Edward N; Guen, Yann Le; Tarawneh, Rawan; Wyss-Coray, Tony; Sung, Yun Ju; Ibanez, Laura; Cruchaga, Carlos

CSF proteomic profiling with amyloid and tau pathology identifies distinctive sex-specific alteration of multiple proteins involved in Alzheimer's disease

脑脊液蛋白质组学分析结合淀粉样蛋白和tau蛋白病理学检测,揭示了阿尔茨海默病相关多种蛋白质的独特性别特异性改变

Do, Anh N; Song, Soomin; Ali, Muhammad; Timsina, Jigyasha; Wang, Lihua; Western, Daniel; Liu, Menghan; Sanford, Jessie; Rosende-Roca, Matitee; Boada, Merce; Puerta, Raquel; Wilson, Edward N; Ruiz, Agustin; Pastor, Pau; Wyss-Coray, Tony; Cruchaga, Carlos; Sung, Yun Ju

Multivariate patterns of plasma biomarkers predict region-specific Alzheimer's pathology and cognitive decline across independent cohorts

血浆生物标志物的多变量模式可预测不同独立队列中特定区域的阿尔茨海默病理和认知衰退

Zamani, Jafar; Vahid, Amirali; Wilson, Edward N; Hosseini, S M Hadi

A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer's disease

脑脊液突触蛋白生物标志物可用于预测阿尔茨海默病患者的认知韧性与认知衰退

Oh, Hamilton Se-Hwee; Urey, Deniz Yagmur; Karlsson, Linda; Zhu, Zeyu; Shen, Yuanyuan; Farinas, Amelia; Timsina, Jigyasha; Duggan, Michael R; Chen, Jingsha; Guldner, Ian H; Morshed, Nader; Yang, Chengran; Western, Daniel; Ali, Muhammad; Le Guen, Yann; Trelle, Alexandra; Herukka, Sanna-Kaisa; Rauramaa, Tuomas; Hiltunen, Mikko; Lipponen, Anssi; Luikku, Antti J; Poston, Kathleen L; Mormino, Elizabeth; Wagner, Anthony D; Wilson, Edward N; Channappa, Divya; Leinonen, Ville; Stevens, Beth; Ehrenberg, Alexander J; Gottesman, Rebecca F; Coresh, Josef; Walker, Keenan A; Zetterberg, Henrik; Bennett, David A; Franzmeier, Nicolai; Hansson, Oskar; Cruchaga, Carlos; Wyss-Coray, Tony

A single-cell atlas to map sex-specific gene-expression changes in blood upon neurodegeneration

利用单细胞图谱绘制神经退行性疾病过程中血液中性别特异性基因表达变化

Grandke, Friederike; Fehlmann, Tobias; Kern, Fabian; Gate, David M; Wolff, Tobias William; Leventhal, Olivia; Channappa, Divya; Hirsch, Pascal; Wilson, Edward N; Meese, Eckart; Liu, Chuanyu; Shi, Quan; Flotho, Matthias; Li, Yongping; Chen, Cynthia; Yu, Yeya; Xu, Jiangshan; Junkin, Michael; Wang, Zhifeng; Wu, Tao; Liu, Longqi; Hou, Yong; Andreasson, Katrin I; Gansen, Jenny S; Mass, Elvira; Poston, Kathleen; Wyss-Coray, Tony; Keller, Andreas

Multi-cohort cerebrospinal fluid proteomics identifies robust molecular signatures across the Alzheimer disease continuum

多队列脑脊液蛋白质组学研究揭示了阿尔茨海默病连续谱中可靠的分子特征。

Ali, Muhammad; Timsina, Jigyasha; Western, Daniel; Liu, Menghan; Beric, Aleksandra; Budde, John; Do, Anh; Heo, Gyujin; Wang, Lihua; Gentsch, Jen; Schindler, Suzanne E; Morris, John C; Holtzman, David M; Ruiz, Agustin; Alvarez, Ignacio; Aguilar, Miquel; Pastor, Pau; Rutledge, Jarod; Oh, Hamilton; Wilson, Edward N; Guen, Yann Le; Khalid, Rana R; Robins, Chloe; Pulford, David J; Tarawneh, Rawan; Ibanez, Laura; Wyss-Coray, Tony; Sung, Yun Ju; Cruchaga, Carlos

Plasma Aβ(42)/Aβ(40) is sensitive to early cerebral amyloid accumulation and predicts risk of cognitive decline across the Alzheimer's disease spectrum

血浆Aβ(42)/Aβ(40)比值对早期脑淀粉样蛋白沉积敏感,并可预测阿尔茨海默病谱系中认知功能下降的风险。

Trelle, Alexandra N; Young, Christina B; Vossler, Hillary; Ramos Benitez, Javier; Cody, Karly A; Mendiola, Justin H; Swarovski, Michelle S; Guen, Yann Le; Feinstein, Igor; Butler, Robert R 3rd; Channappa, Divya; Romero, America; Park, Jennifer; Shahid-Besanti, Marian; Corso, Nicole K; Chau, Kelly; Smith, Amanda N; Skylar-Scott, Irina; Yutsis, Maya V; Fredericks, Carolyn A; Tian, Lu; Younes, Kyan; Kerchner, Geoffrey A; Deutsch, Gayle K; Davidzon, Guido A; Sha, Sharon J; Henderson, Victor W; Longo, Frank M; Greicius, Michael D; Wyss-Coray, Tony; Andreasson, Katrin I; Poston, Kathleen L; Wagner, Anthony D; Mormino, Elizabeth C; Wilson, Edward N

Parkinson's disease is characterized by vitamin B6-dependent inflammatory kynurenine pathway dysfunction.

帕金森病的特征是维生素 B6 依赖性炎症犬尿氨酸通路功能障碍

Wilson Edward N, Umans Jacob, Swarovski Michelle S, Minhas Paras S, Mendiola Justin H, Midttun Øivind, Ulvik Arve, Shahid-Besanti Marian, Linortner Patricia, Mhatre Siddhita D, Wang Qian, Channappa Divya, Corso Nicole K, Tian Lu, Fredericks Carolyn A, Kerchner Geoffrey A, Plowey Edward D, Cholerton Brenna, Ueland Per M, Zabetian Cyrus P, Gray Nora E, Quinn Joseph F, Montine Thomas J, Sha Sharon J, Longo Frank M, Wolk David A, Chen-Plotkin Alice, Henderson Victor W, Wyss-Coray Tony, Wagner Anthony D, Mormino Elizabeth C, Aghaeepour Nima, Poston Kathleen L, Andreasson Katrin I

(18)F-PI-2620 Tau PET is associated with cognitive and motor impairment in Lewy body disease

(18)F-PI-2620 Tau PET 与路易体病患者的认知和运动障碍相关

Winer, Joseph R; Vossler, Hillary; Young, Christina B; Smith, Viktorija; Romero, America; Shahid-Besanti, Marian; Abdelnour, Carla; Wilson, Edward N; Anders, David; Pacheco Morales, Aimara; Andreasson, Katrin I; Yutsis, Maya V; Henderson, Victor W; Davidzon, Guido A; Mormino, Elizabeth C; Poston, Kathleen L

Biomarker‐informed characterization of an ABCA7 tandem repeat expansion in a family with early‐onset Alzheimer’s Disease

利用生物标志物对早发性阿尔茨海默病家族中ABCA7串联重复扩增进行表征

Pericak-Vance, Margaret A; Nam, Younji; DeRosa, Brooke A; Ramirez, Aura M; Ayele, Biniyam A; Whitehead, Patrice G; Adams, Larry D; Golightly, Charles G; Starks, Takiyah D; Laverde-Paz, Juliana; Cukier, Holly N; Akinyemi, Rufus; Sarfo, Fred; Akpalu, Albert; Cuccaro, Michael L; Williams, Scott; Caban-Holt, Allison; Reitz, Christiane; Haines, Jonathan L; Goldie, Byrd S; Rajabli, Farid; Dykxhoorn, Derek M; Young, Juan I; Vance, Jeffery M; Peña‐Tauber, Andrés; Talozzi, Lia; Orias, Holden; Mormino, Elizabeth C; Wilson, Edward N; Greicius, Michael D