日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A general assay platform to study protein pharmacology using ligand-dependent structural dynamics.

利用配体依赖性结构动力学研究蛋白质药理学的通用检测平台

Ciulla Daniel A, Dranchak Patricia K, Aitha Mahesh, van Neer Renier H P, Shah Divia, Tharakan Ravi, Wilson Kelli M, Wang Yuhong, Braisted John C, Inglese James

Targeting NAD+ Metabolism Vulnerability in FH-Deficient Hereditary Leiomyomatosis and Renal Cell Carcinoma with the Novel NAMPT Inhibitor OT-82.

利用新型 NAMPT 抑制剂 OT-82 靶向 FH 缺陷型遗传性平滑肌瘤病和肾细胞癌中的 NAD+ 代谢脆弱性

Najera Susana S, Ricketts Christopher J, Schmidt Laura S, Medina Julia I, Saito Keita, Ileva Lilia, Brender Jeffrey R, James Amy M, Peer Cody J, Gouker Brad, Karim Baktiar O, Chernova Olga, Wells Catherine, Wei Ming-Hui, Yang Youfeng, Zhang Xiaohu, Klumpp-Thomas Carleen, Travers Jameson, Chen Lu, Wilson Kelli M, Issaq Sameer H, Figg William D, Difilippantonio Simone, Kalen Joseph D, Krishna Murali C, Thomas Craig J, Ceribelli Michele, Heske Christine M, Crooks Daniel R, Meier Jordan L

Direct Co-Targeting of Bcl-xL and Mcl-1 Exhibits Synergistic Effects in AR-V7-Expressing CRPC Models.

Bcl-xL 和 Mcl-1 的直接共同靶向在 AR-V7 表达的 CRPC 模型中表现出协同效应

Brim Benjamin C, Leon Andres F, Beatson Erica L, Kindrick Jessica D, Bhadresha Kinjal, Zhang Xiaohu, Napoli Giulia C, Risdon Emily N, Schmidt Keith T, Wilson Kelli M, McKnight Crystal, Beck Erin, Klumpp-Thomas Carleen, Ceribelli Michele, Yin JuanJuan, Sowalsky Adam G, Price Douglas K, Chau Cindy H, Thomas Craig J, Figg William D

A High-Throughput Screening Pipeline to Identify Methyltransferase and Exonuclease Inhibitors of SARS-CoV-2 NSP14

用于鉴定 SARS-CoV-2 NSP14 甲基转移酶和核酸外切酶抑制剂的高通量筛选流程

Hanson, Quinlin; Hu, Xin; Pal, Sourav; Recabo, Katlin; Ye, Lin; Poon, Ivy; Denson, John-Paul; Messing, Simon; Shen, Min; Wilson, Kelli M; Zakharov, Alexey; Esposito, Dominic; Martinez, Natalia J

A landscape of response to drug combinations in non-small cell lung cancer

非小细胞肺癌药物联合治疗反应概况

Nair, Nishanth Ulhas; Greninger, Patricia; Zhang, Xiaohu; Friedman, Adam A; Amzallag, Arnaud; Cortez, Eliane; Sahu, Avinash Das; Lee, Joo Sang; Dastur, Anahita; Egan, Regina K; Murchie, Ellen; Ceribelli, Michele; Crowther, Giovanna S; Beck, Erin; McClanaghan, Joseph; Klump-Thomas, Carleen; Boisvert, Jessica L; Damon, Leah J; Wilson, Kelli M; Ho, Jeffrey; Tam, Angela; McKnight, Crystal; Michael, Sam; Itkin, Zina; Garnett, Mathew J; Engelman, Jeffrey A; Haber, Daniel A; Thomas, Craig J; Ruppin, Eytan; Benes, Cyril H

High-throughput approaches to uncover synergistic drug combinations in leukemia

利用高通量方法发现白血病中的协同药物组合

Chory, Emma J; Wang, Meng; Ceribelli, Michele; Michalowska, Aleksandra M; Golas, Stefan; Beck, Erin; Klumpp-Thomas, Carleen; Chen, Lu; McKnight, Crystal; Itkin, Zina; Wilson, Kelli M; Holland, David; Divakaran, Sanjay; Bradner, James; Khan, Javed; Gryder, Berkley E; Thomas, Craig J; Stanton, Benjamin Z

Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening

利用定量高通量筛选对带注释的多样化化学库进行细胞毒性分析

Lee, Olivia W; Austin, Shelley; Gamma, Madison; Cheff, Dorian M; Lee, Tobie D; Wilson, Kelli M; Johnson, Joseph; Travers, Jameson; Braisted, John C; Guha, Rajarshi; Klumpp-Thomas, Carleen; Shen, Min; Hall, Matthew D

Keeping It Clean: The Cell Culture Quality Control Experience at the National Center for Advancing Translational Sciences

保持清洁:美国国家转化科学促进中心细胞培养质量控制经验

Roth, Jacob S; Lee, Tobie D; Cheff, Dorian M; Gosztyla, Maya L; Asawa, Rosita R; Danchik, Carina; Michael, Sam; Simeonov, Anton; Klumpp-Thomas, Carleen; Wilson, Kelli M; Hall, Matthew D

Therapeutic strategies for diffuse midline glioma from high-throughput combination drug screening

基于高通量联合药物筛选的弥漫性中线胶质瘤治疗策略

Lin, Grant L; Wilson, Kelli M; Ceribelli, Michele; Stanton, Benjamin Z; Woo, Pamelyn J; Kreimer, Sara; Qin, Elizabeth Y; Zhang, Xiaohu; Lennon, James; Nagaraja, Surya; Morris, Patrick J; Quezada, Michael; Gillespie, Shawn M; Duveau, Damien Y; Michalowski, Aleksandra M; Shinn, Paul; Guha, Rajarshi; Ferrer, Marc; Klumpp-Thomas, Carleen; Michael, Sam; McKnight, Crystal; Minhas, Paras; Itkin, Zina; Raabe, Eric H; Chen, Lu; Ghanem, Reem; Geraghty, Anna C; Ni, Lijun; Andreasson, Katrin I; Vitanza, Nicholas A; Warren, Katherine E; Thomas, Craig J; Monje, Michelle