日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Inhibition of histone methyltransferase EZH2 for immune interception of colorectal cancer in Lynch syndrome

抑制组蛋白甲基转移酶 EZH2 用于林奇综合征结直肠癌的免疫阻断

Charles M Bowen ,Fahriye Duzagac ,Abel Martel-Martel ,Laura Reyes-Uribe ,Mahira Zaheer ,Jacklyn Thompson ,Nan Deng ,Ria Sinha ,Soham Mazumdar ,Melissa W Taggart ,Abhinav K Jain ,Elena Tosti ,Winfried Edelmann ,Krishna M Sinha ,Eduardo Vilar

A CAG repeat threshold for therapeutics targeting somatic instability in Huntington's disease

针对亨廷顿氏病躯体不稳定性治疗的 CAG 重复阈值

Sarah G Aldous, Edward J Smith, Christian Landles, Georgina F Osborne, Maria Cañibano-Pico, Iulia M Nita, Jemima Phillips, Yongwei Zhang, Bo Jin, Marissa B Hirst, Caroline L Benn, Brian C Bond, Winfried Edelmann, Jonathan R Greene, Gillian P Bates

Combined inhibition of MTAP and MAT2a mimics synthetic lethality in tumor models via PRMT5 inhibition

MTAP 和 MAT2a 的联合抑制可通过 PRMT5 抑制模拟肿瘤模型中的合成致死率

Gabriel T Bedard, Nord Gilaj, Karina Peregrina, Isabella Brew, Elena Tosti, Karl Shaffer, Peter C Tyler, Winfried Edelmann, Leonard H Augenlicht, Vern L Schramm

Blockade of the immunosuppressive KIR2DL5/PVR pathway elicits potent human NK cell-mediated antitumor immunity

阻断免疫抑制 KIR2DL5/PVR 通路可引发强大的人类 NK 细胞介导的抗肿瘤免疫

Xiaoxin Ren, Mou Peng, Peng Xing, Yao Wei, Phillip M Galbo Jr, Devin Corrigan, Hao Wang, Yingzhen Su, Xiaoshen Dong, Qizhe Sun, Yixian Li, Xiaoyu Zhang, Winfried Edelmann, Deyou Zheng, Xingxing Zang

Genome Replication Is Associated With Release of Immunogenic DNA Waste

基因组复制与免疫原性 DNA 废物的释放有关

Nadja Schubert, Tina Schumann, Elena Daum, Karolin Flade, Yan Ge, Lara Hagedorn, Winfried Edelmann, Luise Müller, Marc Schmitz, Gunnar Kuut, Veit Hornung, Rayk Behrendt, Axel Roers

Molecular structures and mechanisms of DNA break processing in mouse meiosis

小鼠减数分裂中 DNA 断裂处理的分子结构和机制

Shintaro Yamada, Anjali Gupta Hinch, Hisashi Kamido, Yongwei Zhang, Winfried Edelmann, Scott Keeney

Homozygous hydroxymethylbilane synthase knock-in mice provide pathogenic insights into the severe neurological impairments present in human homozygous dominant acute intermittent porphyria

纯合羟甲基胆烷合酶敲入小鼠为人类纯合显性急性间歇性卟啉症中存在的严重神经系统损伤提供了致病见解

Makiko Yasuda, Lin Gan, Brenden Chen, Chunli Yu, Jinglan Zhang, Miguel A Gama-Sosa, Daniela D Pollak, Stefanie Berger, John D Phillips, Winfried Edelmann, Robert J Desnick

Mutation of the ATPase Domain of MutS Homolog-5 (MSH5) Reveals a Requirement for a Functional MutSγ Complex for All Crossovers in Mammalian Meiosis

MutS 同源物-5 (MSH5) 的 ATPase 结构域突变表明,哺乳动物减数分裂中的所有交叉都需要功能性 MutSγ 复合物

Carolyn R Milano, J Kim Holloway, Yongwei Zhang, Bo Jin, Cameron Smith, Aviv Bergman, Winfried Edelmann, Paula E Cohen

MutLγ promotes repeat expansion in a Fragile X mouse model while EXO1 is protective

MutLγ 在脆性 X 小鼠模型中促进重复扩增,而 EXO1 具有保护作用

Xiaonan Zhao, Yongwei Zhang, Kenneth Wilkins, Winfried Edelmann, Karen Usdin

The ISWI ATPase Smarca5 (Snf2h) Is Required for Proliferation and Differentiation of Hematopoietic Stem and Progenitor Cells

ISWI ATPase Smarca5 (Snf2h) 是造血干细胞和祖细胞增殖和分化所必需的

Juraj Kokavec, Tomas Zikmund, Filipp Savvulidi, Vojtech Kulvait, Winfried Edelmann, Arthur I Skoultchi, Tomas Stopka