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Liu, Fang; He, Rui; Sheeley, Thomas; Scheiblin, David A; Lockett, Stephen J; Ridnour, Lisa A; Wink, David A; Jensen, Mark; Cortner, Janelle; Zaki, George

细胞生物学

单细胞

发表日期：2026

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TRAIL induces cytokine production via the NFkB2 pathway promoting neutrophil chemotaxis and neutrophil-mediated immune-suppression in triple negative breast cancer cells

TRAIL通过NF-κB2通路诱导细胞因子产生，促进中性粒细胞趋化和中性粒细胞介导的免疫抑制，从而增强三阴性乳腺癌细胞的免疫活性。

期刊:Cancer Letters

影响因子:10.1

doi:10.1016/j.canlet.2025.217692

Kundu, Manjari; Greer, Yoshimi E; Lobanov, Alexei; Ridnour, Lisa; Donahue, Renee N; Ng, Yeap; Ratnayake, Shashi; White, Karley; Voeller, Donna; Weltz, Sarah; Chen, Qingrong; Lockett, Stephen J; Cam, Maggie; Meerzaman, Daoud; Wink, David A; Weigert, Roberto; Lipkowitz, Stanley

Elevated tumor NOS2/COX2 promotes immunosuppressive phenotypes associated with poor survival in ER- breast cancer

肿瘤NOS2/COX2水平升高会促进与ER阴性乳腺癌患者预后不良相关的免疫抑制表型。

期刊:JCI Insight

影响因子:6.1

doi:10.1172/jci.insight.193091

Ridnour, Lisa A; Cheng, Robert Ys; Heinz, William F; Pore, Milind; Gonzalez, Ana L; Femino, Elise L; Moffat, Rebecca L; Wink, Adelaide L; Imtiaz, Fatima; Coutinho, Leandro L; Butcher, Donna; Edmondson, Elijah F; Rangel, M Cristina; Wong, Stephen Tc; Lipkowitz, Stanley; Glynn, Sharon A; Vitek, Michael P; McVicar, Daniel W; Li, Xiaoxian; Anderson, Stephen K; Paolocci, Nazareno; Hewitt, Stephen M; Ambs, Stefan; Billiar, Timothy R; Chang, Jenny C; Lockett, Stephen J; Wink, David A

RETRACTED: Waheed et al. Nitric Oxide Donor DETA/NO Inhibits the Growth of Endometrial Cancer Cells by Upregulating the Expression of RASSF1 and CDKN1A. Molecules 2019, 24, 3722

撤稿：Waheed 等人，《一氧化氮供体 DETA/NO 通过上调 RASSF1 和 CDKN1A 的表达抑制子宫内膜癌细胞的生长》，Molecules 2019, 24, 3722

期刊:Molecules

影响因子:4.6

doi:10.3390/molecules30224362

Waheed, Sana; Cheng, Robert Ys; Casablanca, Yovanni; Maxwell, G Larry; Wink, David A; Syed, Viqar

SPAC: a scalable, integrated enterprise platform for end-to-end single cell spatial analysis of multiplexed tissue imaging

SPAC：一个可扩展的集成企业平台，用于对多重组织成像进行端到端的单细胞空间分析

期刊:

影响因子:

doi:10.1101/2025.04.02.646782

Liu, Fang; He, Rui; Sheeley, Thomas; Scheiblin, David; Lockett, Stephen J; Ridnour, Lisa A; Wink, David A; Jensen, Mark; Cortner, Janelle; Zaki, George

NOS2 and COX-2 Co-Expression Promotes Cancer Progression: A Potential Target for Developing Agents to Prevent or Treat Highly Aggressive Breast Cancer

NOS2 和 COX-2 共表达促进癌症进展：开发预防或治疗高侵袭性乳腺癌药物的潜在靶点

期刊:International Journal of Molecular Sciences

影响因子:4.9

doi:10.3390/ijms25116103

Coutinho, Leandro L; Femino, Elise L; Gonzalez, Ana L; Moffat, Rebecca L; Heinz, William F; Cheng, Robert Y S; Lockett, Stephen J; Rangel, M Cristina; Ridnour, Lisa A; Wink, David A

TRAIL-induced cytokine production via NFKB2 pathway promotes neutrophil chemotaxis and immune suppression in triple negative breast cancers

TRAIL通过NFKB2通路诱导细胞因子产生，促进三阴性乳腺癌中性粒细胞趋化和免疫抑制。

期刊:

影响因子:

doi:10.1101/2024.07.19.604341

Kundu, Manjari; Greer, Yoshimi E; Lobanov, Alexei; Ridnour, Lisa; Donahue, Renee N; Ng, Yeap; Ratnayake, Shashi; Voeller, Donna; Weltz, Sarah; Chen, Qingrong; Lockett, Stephen J; Cam, Maggie; Meerzaman, Daoud; Wink, David A; Weigert, Roberto; Lipkowitz, Stanley

Targeting Nitric Oxide: Say NO to Metastasis

靶向一氧化氮：向转移说不

期刊:Clinical Cancer Research

影响因子:10.2

doi:10.1158/1078-0432.CCR-22-2791

Reddy, Tejaswini P; Glynn, Sharon A; Billiar, Timothy R; Wink, David A; Chang, Jenny C

发表日期：2023

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New nitrosyl ruthenium complexes with combined activities for multiple cardiovascular disorders

新型亚硝酰钌配合物具有治疗多种心血管疾病的综合活性

期刊:Dalton Transactions

影响因子:3.3

doi:10.1039/d3dt00059a

Gouveia Júnior, Florêncio Sousa; Silveira, João Alison de Moraes; Holanda, Thais Muratori; Marinho, Aline Diogo; Ridnour, Lisa A; Wink, David A; de Siqueira, Rodrigo José Bezerra; Monteiro, Helena Serra Azul; Sousa, Eduardo Henrique Silva de; Lopes, Luiz Gonzaga de França

Interferon-gamma is Quintessential for NOS2 and COX2 Expression in ER (-) Breast Tumors that Lead to Poor Outcome

干扰素-γ对于ER(-)乳腺肿瘤中NOS2和COX2的表达至关重要，而这些肿瘤会导致不良预后。

期刊:

影响因子:

doi:10.1101/2023.04.06.535916

Cheng, Robert Ys; Ridnour, Lisa A; Wink, Adelaide L; Gonzalez, Ana L; Femino, Elise L; Rittscher, Helene; Somasundarum, Veena; Heinz, William F; Coutinho, Leandro; Cristina Rangel, M; Edmondson, Elijah F; Butcher, Donna; Kinders, Robert J; Li, Xiaoxian; Wong, Stephen T C; McVicar, Daniel W; Anderson, Steven K; Pore, Milind; Hewitt, Stephen M; Billiar, Timothy R; Glynn, Sharon; Chang, Jenny C; Lockett, Stephen J; Ambs, Stefan; Wink, David A

SPAC: a scalable and integrated enterprise platform for single-cell spatial analysis

SPAC：一个可扩展且集成的单细胞空间分析企业平台

TRAIL induces cytokine production via the NFkB2 pathway promoting neutrophil chemotaxis and neutrophil-mediated immune-suppression in triple negative breast cancer cells

TRAIL通过NF-κB2通路诱导细胞因子产生，促进中性粒细胞趋化和中性粒细胞介导的免疫抑制，从而增强三阴性乳腺癌细胞的免疫活性。

Elevated tumor NOS2/COX2 promotes immunosuppressive phenotypes associated with poor survival in ER- breast cancer

肿瘤NOS2/COX2水平升高会促进与ER阴性乳腺癌患者预后不良相关的免疫抑制表型。

RETRACTED: Waheed et al. Nitric Oxide Donor DETA/NO Inhibits the Growth of Endometrial Cancer Cells by Upregulating the Expression of RASSF1 and CDKN1A. Molecules 2019, 24, 3722

撤稿：Waheed 等人，《一氧化氮供体 DETA/NO 通过上调 RASSF1 和 CDKN1A 的表达抑制子宫内膜癌细胞的生长》，Molecules 2019, 24, 3722

SPAC: a scalable, integrated enterprise platform for end-to-end single cell spatial analysis of multiplexed tissue imaging

SPAC：一个可扩展的集成企业平台，用于对多重组织成像进行端到端的单细胞空间分析

NOS2 and COX-2 Co-Expression Promotes Cancer Progression: A Potential Target for Developing Agents to Prevent or Treat Highly Aggressive Breast Cancer

NOS2 和 COX-2 共表达促进癌症进展：开发预防或治疗高侵袭性乳腺癌药物的潜在靶点

TRAIL-induced cytokine production via NFKB2 pathway promotes neutrophil chemotaxis and immune suppression in triple negative breast cancers

TRAIL通过NFKB2通路诱导细胞因子产生，促进三阴性乳腺癌中性粒细胞趋化和免疫抑制。

Targeting Nitric Oxide: Say NO to Metastasis

靶向一氧化氮：向转移说不

New nitrosyl ruthenium complexes with combined activities for multiple cardiovascular disorders

新型亚硝酰钌配合物具有治疗多种心血管疾病的综合活性

Interferon-gamma is Quintessential for NOS2 and COX2 Expression in ER (-) Breast Tumors that Lead to Poor Outcome

干扰素-γ对于ER(-)乳腺肿瘤中NOS2和COX2的表达至关重要，而这些肿瘤会导致不良预后。