日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
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2025
2026
影响因子:
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Mavacamten inhibits myosin activity by stabilizing the myosin interacting-heads motif and stalling motor force generation

Mavacamten通过稳定肌球蛋白相互作用头基序并阻滞马达力生成来抑制肌球蛋白活性。

期刊:Science Advances
影响因子:12.5
doi:10.1126/sciadv.aea9335
McMillan, Sean N; Pitts, Jaime R T; Barua, Bipasha; Winkelmann, Donald A; Scarff, Charlotte A
发表日期：2026
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Swinging lever mechanism of myosin directly shown by time-resolved cryo-EM

时间分辨冷冻电镜直接揭示肌球蛋白的摆动杠杆机制

期刊:Nature
影响因子:48.5
doi:10.1038/s41586-025-08876-5
Klebl, David P; McMillan, Sean N; Risi, Cristina; Forgacs, Eva; Virok, Betty; Atherton, Jennifer L; Harris, Sarah A; Stofella, Michele; Winkelmann, Donald A; Sobott, Frank; Galkin, Vitold E; Knight, Peter J; Muench, Stephen P; Scarff, Charlotte A; White, Howard D
发表日期：2025
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A myosin hypertrophic cardiomyopathy mutation disrupts the super-relaxed state and boosts contractility by enhanced actin attachment

肌球蛋白肥厚型心肌病突变会破坏超松弛状态，并通过增强肌动蛋白附着来提高收缩力。

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2521561122
Cail, Robert C; Barua, Bipasha; Báez-Cruz, Faviolla A; Winkelmann, Donald A; Goldman, Yale E; Ostap, E Michael
心血管
心肌病
发表日期：2025
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S2Tag, a novel affinity tag for the capture and immobilization of coiled-coil proteins: Application to the study of human β-cardiac myosin

S2Tag，一种用于捕获和固定卷曲螺旋蛋白的新型亲和标签：在人β-心肌肌球蛋白研究中的应用

期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1016/j.jbc.2025.110776
Barua, Bipasha; Cail, Robert C; Goldman, Yale E; Ostap, E Michael; Winkelmann, Donald A
发表日期：2025
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Dynamics of β-cardiac myosin between the super-relaxed and disordered-relaxed states.

β-心肌肌球蛋白在超松弛状态和无序松弛状态之间的动力学

期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1016/j.jbc.2025.108412
Cail Robert C, Báez-Cruz Faviolla A, Winkelmann Donald A, Goldman Yale E, Ostap E Michael
心血管
发表日期：2025
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Mavacamten inhibits myosin activity by stabilising the myosin interacting-heads motif and stalling motor force generation

Mavacamten通过稳定肌球蛋白相互作用头基序并阻滞马达力生成来抑制肌球蛋白活性。

期刊:
影响因子:
doi:10.1101/2025.02.12.637875
McMillan, Sean N; Pitts, Jaime R T; Barua, Bipasha; Winkelmann, Donald A; Scarff, Charlotte A
发表日期：2025
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Single molecule mechanics resolves the earliest events in force generation by cardiac myosin

单分子力学解析了心肌肌球蛋白产生力的最早期事件

期刊:Elife
影响因子:6.4
doi:10.7554/eLife.49266
Woody, Michael S; Winkelmann, Donald A; Capitanio, Marco; Ostap, E Michael; Goldman, Yale E
发表日期：2019
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A periodic pattern of evolutionarily conserved basic and acidic residues constitutes the binding interface of actin-tropomyosin

肌动蛋白-原肌球蛋白的结合界面由进化上保守的碱性和酸性残基的周期性排列构成。

期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1074/jbc.M113.451161
Barua, Bipasha; Fagnant, Patricia M; Winkelmann, Donald A; Trybus, Kathleen M; Hitchcock-DeGregori, Sarah E
发表日期：2013
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Regulation of actin-myosin interaction by conserved periodic sites of tropomyosin

肌动蛋白-肌球蛋白相互作用的调控是通过原肌球蛋白的保守周期性位点实现的

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.1212754109
Barua, Bipasha; Winkelmann, Donald A; White, Howard D; Hitchcock-DeGregori, Sarah E
信号转导
发表日期：2012
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