日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Intramembrane proteolysis of β-amyloid precursor protein by γ-secretase is an unusually slow process

γ-分泌酶对β-淀粉样前体蛋白的膜内蛋白水解是一个异常缓慢的过程。

Kamp, Frits; Winkler, Edith; Trambauer, Johannes; Ebke, Amelie; Fluhrer, Regina; Steiner, Harald

Generation of Alzheimer disease-associated amyloid β42/43 peptide by γ-secretase can be inhibited directly by modulation of membrane thickness.

α-分泌酶产生的阿尔茨海默病相关淀粉样蛋白β42/43肽可通过调节膜厚度直接抑制

Winkler Edith, Kamp Frits, Scheuring Johannes, Ebke Amelie, Fukumori Akio, Steiner Harald

Bepridil and amiodarone simultaneously target the Alzheimer's disease beta- and gamma-secretase via distinct mechanisms

倍普地尔和胺碘酮通过不同的机制同时靶向阿尔茨海默病β-分泌酶和γ-分泌酶。

Mitterreiter, Stefan; Page, Richard M; Kamp, Frits; Hopson, Jessika; Winkler, Edith; Ha, Huy-Riem; Hamid, Runa; Herms, Jochen; Mayer, Thomas U; Nelson, Deborah J; Steiner, Harald; Stahl, Tobias; Zeitschel, Ulrike; Rossner, Steffen; Haass, Christian; Lichtenthaler, Stefan F

Chemical cross-linking provides a model of the gamma-secretase complex subunit architecture and evidence for close proximity of the C-terminal fragment of presenilin with APH-1.

化学交联提供了γ-分泌酶复合物亚基结构的模型,并证明了早老素C端片段与APH-1的紧密接近

Steiner Harald, Winkler Edith, Haass Christian