日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Crystal structure of fatty acid thioesterase A bound by 129 fragments provides diverse development opportunities

脂肪酸硫酯酶A与129个片段结合的晶体结构提供了多种开发机会

Kot, Ekaterina; Ferla, Matteo Paolo; Hollinshead, Patricia Helen; Tomlinson, Charles William Ernest; Fearon, Daren; Aschenbrenner, Jasmin Cara; Koekemoer, Lizbé; Winokan, Max; Fairhead, Michael; Ni, Xiaomin; Chalk, Rod; England, Katherine Sara; Varga, Laura Ortega; Montgomery, Mark Greer; Mulholland, Nicholas Phillip; von Delft, Frank

Combined crystallographic fragment screening and deep mutational scanning enable discovery of Zika virus NS2B-NS3 protease inhibitors

结合晶体学片段筛选和深度突变扫描,可以发现寨卡病毒NS2B-NS3蛋白酶抑制剂。

Ni, Xiaomin; Richardson, R Blake; Godoy, Andre Schutzer; Ferla, Matteo P; Kikawa, Caroline; Scheen, Jenke; Hannon, William W; Capkin, Eda; Lahav, Noa; Balcomb, Blake H; Marples, Peter G; Fairhead, Michael; Wang, SiYi; Williams, Eleanor P; Tomlinson, Charles W E; Aschenbrenner, Jasmin C; Lithgo, Ryan M; Winokan, Max; Giroud, Charline; Dolci, Isabela; Fernandes, Rafaela Sachetto; Oliva, Glaucius; Chandran, Anu V; Xavier, Mary-Ann; Walsh, Martin A; Thompson, Warren; Bloom, Jesse D; Kenton, Nathaniel T; Lee, Alpha A; von Delft, Annette; Barr, Haim; Kirkegaard, Karla; Koekemoer, Lizbé; Fearon, Daren; Evans, Matthew J; von Delft, Frank

High-throughput crystallographic fragment screening of Zika virus NS3 Helicase

寨卡病毒NS3解旋酶的高通量晶体学片段筛选

Godoy, Andre Schutzer; Giroud, Charline; Mesquita, Nathalya C M R; Noske, Gabriela Dias; Gawriljuk, Victor Oliveira; Lithgo, Ryan M; Balcomb, Blake H; Aschenbrenner, Jasmin Cara; Tomlinson, Charles W E; Winokan, Max; Scheen, Jenke; MacDermott-Opeskin, Hugo; Marples, Peter George; Chandran, Anu V; Ni, Xiaomin; Thompson, Warren; Fairhead, Michael; Fearon, Daren; Koekemoer, Lizbé; Xavier, Mary-Ann Elvina; Walsh, Martin; Oliva, Glaucius; von Delft, Frank

Crystallographic Fragment Screen of Coxsackievirus A16 2A Protease identifies new opportunities for the development of broad-spectrum anti-enterovirals

柯萨奇病毒A16 2A蛋白酶的晶体学片段筛选为开发广谱抗肠道病毒药物提供了新的契机

Lithgo, Ryan M; Tomlinson, Charles W E; Fairhead, Michael; Winokan, Max; Thompson, Warren; Wild, Conor; Aschenbrenner, Jasmin Cara; Balcomb, Blake H; Marples, Peter G; Chandran, Anu V; Golding, Mathew; Koekemoer, Lizbe; Williams, Eleanor P; Wang, SiYl; Ni, Xiaomin; MacLean, Elizabeth; Giroud, Charline; Godoy, Andre Schutzer; Xavier, Mary-Ann; Walsh, Martin; Fearon, Daren; von Delft, Frank

Identifying novel chemical matter against the Chikungunya virus nsP3 macrodomain through crystallographic fragment screening

通过晶体学片段筛选鉴定针对基孔肯雅病毒nsP3宏结构域的新型化学物质

Aschenbrenner, Jasmin C; de Godoy, Andre Schutzer; Fairhead, Michael; Tomlinson, Charles W E; Winokan, Max; Balcomb, Blake H; Capkin, Eda; Chandran, Anu V; Golding, Mathew; Koekemoer, Lizbe; Lithgo, Ryan M; Marples, Peter G; Ni, Xiaomin; Thompson, Warren; Wild, Conor; Xavier, Mary-Ann E; Fearon, Daren; von Delft, Frank

Quantum Tunnelling Effects in the Guanine-Thymine Wobble Misincorporation via Tautomerism

互变异构体介导的鸟嘌呤-胸腺嘧啶摆动错配中的量子隧穿效应

Slocombe, Louie; Winokan, Max; Al-Khalili, Jim; Sacchi, Marco

Multiscale simulations reveal the role of PcrA helicase in protecting against spontaneous point mutations in DNA

多尺度模拟揭示了PcrA解旋酶在保护DNA免受自发点突变中的作用。

Winokan, Max; Slocombe, Louie; Al-Khalili, Jim; Sacchi, Marco

Tautomerisation Mechanisms in the Adenine-Thymine Nucleobase Pair during DNA Strand Separation

DNA链分离过程中腺嘌呤-胸腺嘧啶核碱基对的互变异构机制

King, Benjamin; Winokan, Max; Stevenson, Paul; Al-Khalili, Jim; Slocombe, Louie; Sacchi, Marco

Proton transfer during DNA strand separation as a source of mutagenic guanine-cytosine tautomers

DNA链分离过程中的质子转移是诱变性鸟嘌呤-胞嘧啶互变异构体的来源

Slocombe, Louie; Winokan, Max; Al-Khalili, Jim; Sacchi, Marco

An Infant Formula with Large, Milk Phospholipid-Coated Lipid Droplets Supports Adequate Growth and Is Well-Tolerated in Healthy, Term Asian Infants: A Randomized, Controlled Double-Blind Clinical Trial

一项随机、对照、双盲临床试验表明,含有大颗粒、乳磷脂包被脂滴的婴儿配方奶粉能够支持健康足月亚洲婴儿的充分生长发育,且耐受性良好。

Teoh, Oon Hoe; Lin, Tan Pih; Abrahamse-Berkeveld, Marieke; Winokan, Antoinette; Chong, Yap Seng; Yap, Fabian; Marintcheva-Petrova, Maya; van der Beek, Eline M; Shek, Lynette P