Winstedt相关文献与解析，生知库 | 链接生命科学的每一步

Imlifidase Desensitization in Crossmatch-positive, Highly Sensitized Kidney Transplant Recipients: Results of an International Phase 2 Trial (Highdes)

伊马利菲酶脱敏治疗交叉配型阳性、高度致敏的肾移植受者：一项国际 2 期试验 (Highdes) 的结果

Jordan, Stanley C; Legendre, Christophe; Desai, Niraj M; Lorant, Tomas; Bengtsson, Mats; Lonze, Bonnie E; Vo, Ashley A; Runström, Anna; Laxmyr, Lena; Sjöholm, Kristoffer; Schiött, Åsa; Sonesson, Elisabeth; Wood, Kathryn; Winstedt, Lena; Kjellman, Christian; Montgomery, Robert A

发表日期：2021

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Safety, immunogenicity, pharmacokinetics, and efficacy of degradation of anti-HLA antibodies by IdeS (imlifidase) in chronic kidney disease patients

在慢性肾脏病患者中，IdeS（伊米利酶）降解抗HLA抗体的安全性、免疫原性、药代动力学和疗效

期刊:American Journal of Transplantation

影响因子:8.2

doi:10.1111/ajt.14733

Lorant, Tomas; Bengtsson, Mats; Eich, Torsten; Eriksson, Britt-Marie; Winstedt, Lena; Järnum, Sofia; Stenberg, Yvonne; Robertson, Anna-Karin; Mosén, Kristina; Björck, Lars; Bäckman, Lars; Larsson, Erik; Wood, Kathryn; Tufveson, Gunnar; Kjellman, Christian

免疫/内分泌

发表日期：2018

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Enzymatic Inactivation of Endogenous IgG by IdeS Enhances Therapeutic Antibody Efficacy

IdeS 酶促灭活内源性 IgG 可增强抗体治疗功效

期刊:Molecular Cancer Therapeutics

影响因子:5.3

doi:10.1158/1535-7163.MCT-17-0108

Sofia Järnum, Anna Runström, Robert Bockermann, Lena Winstedt, Max Crispin, Christian Kjellman

信号转导

发表日期：2017

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The Bacterial Enzyme IdeS Cleaves the IgG-Type of B Cell Receptor (BCR), Abolishes BCR-Mediated Cell Signaling, and Inhibits Memory B Cell Activation

细菌酶 IdeS 可裂解 IgG 型 B 细胞受体 (BCR)，消除 BCR 介导的细胞信号传导，并抑制记忆 B 细胞活化

期刊:Journal of Immunology

影响因子:3.6

doi:10.4049/jimmunol.1501929

Sofia Järnum, Robert Bockermann, Anna Runström, Lena Winstedt, Christian Kjellman

Complete Removal of Extracellular IgG Antibodies in a Randomized Dose-Escalation Phase I Study with the Bacterial Enzyme IdeS--A Novel Therapeutic Opportunity

利用细菌酶 IdeS 在随机剂量递增 I 期研究中完全去除细胞外 IgG 抗体——一种新的治疗机会

期刊:PLoS One

影响因子:2.9

doi:10.1371/journal.pone.0132011

Lena Winstedt, Sofia Järnum, Emma Andersson Nordahl, Andreas Olsson, Anna Runström, Robert Bockermann, Christofer Karlsson, Johan Malmström, Gabriella Samuelsson Palmgren, Ulf Malmqvist, Lars Björck, Christian Kjellman

Imlifidase-generated Single-cleaved IgG: Implications for Transplantation

伊米利菲酶生成的单裂解IgG：对移植的意义

Imlifidase Desensitization in Crossmatch-positive, Highly Sensitized Kidney Transplant Recipients: Results of an International Phase 2 Trial (Highdes)

伊马利菲酶脱敏治疗交叉配型阳性、高度致敏的肾移植受者：一项国际 2 期试验 (Highdes) 的结果

Safety, immunogenicity, pharmacokinetics, and efficacy of degradation of anti-HLA antibodies by IdeS (imlifidase) in chronic kidney disease patients

在慢性肾脏病患者中，IdeS（伊米利酶）降解抗HLA抗体的安全性、免疫原性、药代动力学和疗效

Enzymatic Inactivation of Endogenous IgG by IdeS Enhances Therapeutic Antibody Efficacy

IdeS 酶促灭活内源性 IgG 可增强抗体治疗功效

The Bacterial Enzyme IdeS Cleaves the IgG-Type of B Cell Receptor (BCR), Abolishes BCR-Mediated Cell Signaling, and Inhibits Memory B Cell Activation

细菌酶 IdeS 可裂解 IgG 型 B 细胞受体 (BCR)，消除 BCR 介导的细胞信号传导，并抑制记忆 B 细胞活化

Complete Removal of Extracellular IgG Antibodies in a Randomized Dose-Escalation Phase I Study with the Bacterial Enzyme IdeS--A Novel Therapeutic Opportunity

利用细菌酶 IdeS 在随机剂量递增 I 期研究中完全去除细胞外 IgG 抗体——一种新的治疗机会