日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Improving atlas-scale single-cell annotation models with hierarchical cross-entropy loss

利用分层交叉熵损失改进图谱尺度的单细胞注释模型

Cultrera di Montesano, Sebastiano; D'Ascenzo, Davide; Raghavan, Srivatsan; Amini, Ava P; Winter, Peter S; Crawford, Lorin

EGFR inhibitor-resistant lung cancers exhibit collateral sensitivity to a covalent, cysteine-independent KEAP1 oligomerizing molecular bridge.

对 EGFR 抑制剂耐药的肺癌表现出对共价、不依赖半胱氨酸的 KEAP1 寡聚化分子桥的协同敏感性。

Bassil Christopher F, Dillon Kerry, Anderson Gray R, Mayro Benjamin, Askin Kayleigh N, Winter Peter S, Harry Stefan, Gruber Samuel, Hall Tierney M, Hoj Jacob P, Cerda-Smith Christian, Hutchinson Haley M, Killarney Shane T, Heffernan Ava, Teddy Caroline, Singleton Katherine R, Qin Li, Jubien-Girard Kévin, Favreau Cécile, Robert Guillaume, Tivon Barr, Livnah Ella, London Nir, Benhida Rachid, Auberger Patrick, Pendergast Ann Marie, Bar-Peled Liron, Lonard David M, Martin Anthony R, Puissant Alexandre, Wood Kris C

Artificial variables help to avoid over-clustering in single-cell RNA sequencing

人工变量有助于避免单细胞RNA测序中的过度聚类。

DenAdel, Alan; Ramseier, Michelle L; Navia, Andrew W; Shalek, Alex K; Raghavan, Srivatsan; Winter, Peter S; Amini, Ava P; Crawford, Lorin

Consequences of training data composition for deep learning models in single-cell biology

训练数据组成对单细胞生物学深度学习模型的影响

Nadig, Ajay; Thoutam, Akshaya; Hughes, Madeline; Gupta, Anay; Navia, Andrew W; Fusi, Nicolo; Raghavan, Srivatsan; Winter, Peter S; Amini, Ava P; Crawford, Lorin

Adaptive resampling for improved machine learning in imbalanced single-cell datasets

自适应重采样技术在不平衡单细胞数据集中改进机器学习性能

Navidi, Zeinab; Thoutam, Akshaya; Hughes, Madeline; Raghavan, Srivatsan; Winter, Peter S; Crawford, Lorin; Amini, Ava P

Evaluating the role of pre-training dataset size and diversity on single-cell foundation model performance

评估预训练数据集大小和多样性对单细胞基础模型性能的影响

DenAdel, Alan; Hughes, Madeline; Thoutam, Akshaya; Gupta, Anay; Navia, Andrew W; Fusi, Nicolo; Raghavan, Srivatsan; Winter, Peter S; Amini, Ava P; Crawford, Lorin

Cancer tissue of origin constrains the growth and metabolism of metastases.

原发癌组织会限制转移灶的生长和代谢

Sivanand Sharanya, Gultekin Yetis, Winter Peter S, Vermeulen Sidney Y, Tchourine Konstantine M, Abbott Keene L, Danai Laura V, Gourgue Florian, Do Brian T, Crowder Kayla, Kunchok Tenzin, Lau Allison N, Darnell Alicia M, Jefferson Alexandria, Morita Satoru, Duda Dan G, Aguirre Andrew J, Wolpin Brian M, Henning Nicole, Spanoudaki Virginia, Maiorino Laura, Irvine Darrell J, Yilmaz Omer H, Lewis Caroline A, Vitkup Dennis, Shalek Alex K, Vander Heiden Matthew G

Spatially Resolved Single-Cell Assessment of Pancreatic Cancer Expression Subtypes Reveals Co-expressor Phenotypes and Extensive Intratumoral Heterogeneity

空间分辨单细胞分析胰腺癌表达亚型揭示共表达表型和广泛的肿瘤内异质性

Williams, Hannah L; Dias Costa, Andressa; Zhang, Jinming; Raghavan, Srivatsan; Winter, Peter S; Kapner, Kevin S; Ginebaugh, Scott P; Väyrynen, Sara A; Väyrynen, Juha P; Yuan, Chen; Navia, Andrew W; Wang, Junning; Yang, Annan; Bosse, Timothy L; Kalekar, Radha L; Lowder, Kristen E; Lau, Mai Chan; Elganainy, Dalia; Morales-Oyarvide, Vicente; Rubinson, Douglas A; Singh, Harshabad; Perez, Kimberly; Cleary, James M; Clancy, Thomas E; Wang, Jiping; Mancias, Joseph D; Brais, Lauren K; Hill, Emma R; Kozak, Margaret M; Linehan, David C; Dunne, Richard F; Chang, Daniel T; Koong, Albert C; Hezel, Aram F; Hahn, William C; Shalek, Alex K; Aguirre, Andrew J; Nowak, Jonathan A; Wolpin, Brian M

Optofluidic real-time cell sorter for longitudinal CTC studies in mouse models of cancer

用于小鼠癌症模型中循环肿瘤细胞纵向研究的光流控实时细胞分选仪

Hamza, Bashar; Ng, Sheng Rong; Prakadan, Sanjay M; Delgado, Francisco Feijó; Chin, Christopher R; King, Emily M; Yang, Lucy F; Davidson, Shawn M; DeGouveia, Kelsey L; Cermak, Nathan; Navia, Andrew W; Winter, Peter S; Drake, Riley S; Tammela, Tuomas; Li, Carman Man-Chung; Papagiannakopoulos, Thales; Gupta, Alejandro J; Shaw Bagnall, Josephine; Knudsen, Scott M; Vander Heiden, Matthew G; Wasserman, Steven C; Jacks, Tyler; Shalek, Alex K; Manalis, Scott R

PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation

PIK3CA突变能够通过mTOR介导的MCL-1翻译靶向治疗乳腺肿瘤依赖性。

Anderson, Gray R; Wardell, Suzanne E; Cakir, Merve; Crawford, Lorin; Leeds, Jim C; Nussbaum, Daniel P; Shankar, Pallavi S; Soderquist, Ryan S; Stein, Elizabeth M; Tingley, Jennifer P; Winter, Peter S; Zieser-Misenheimer, Elizabeth K; Alley, Holly M; Yllanes, Alexander; Haney, Victoria; Blackwell, Kimberly L; McCall, Shannon J; McDonnell, Donald P; Wood, Kris C