IMPORTANCE trial: a provisional study-design of a single-center, phase II, double-blinded, placebo-controlled, randomized, 4-week study to compare the efficacy and safety of intranasal esketamine in chronic opioid refractory pain
IMPORTANCE试验：一项单中心、II期、双盲、安慰剂对照、随机、为期4周的研究的初步研究设计，旨在比较鼻内给药艾司氯胺酮治疗慢性阿片类药物难治性疼痛的疗效和安全性。
期刊:F1000Research
影响因子:
doi:10.12688/f1000research.27809.1
Fernandes, Mauricio; Schelotto, Magdalena; Doldi, Philipp Maximilian; Milani, Giovanna; Ariza Manzano, Abul Andrés; Perera Valdivia, Doriam; Winter Matos, Alexandra Marie; Hamdy Abdelrahim, Yasmin; Hamad Bek, Shaza Ahmed; Benitez, Benito K; Romanelli Tavares, Vanessa Luiza; Basendwah, Abdulrahim M; Albuquerque Sousa, Luis Henrique; Xavier, Naiara Faria; Zertuche Maldonado, Tania; Toyomi de Oliveira, Sarah; Chaker, Melisa; Menon Miyake, Michelle; Uygur Kucukseymen, Elif; Waqar, Kinza; Alkhozondar, Ola M J; Bernardo da Silva, Ricardo; Droppelmann, Guilhermo; Vaz de Macedo, Antonio; Nakamura, Rui; Fregni, Felipe
