Tailored SirReal-type inhibitors enhance SIRT2 inhibition through ligand stabilization and disruption of NAD(+) co-factor binding.
定制的 SirReal 型抑制剂通过配体稳定和破坏 NAD(+) 辅因子结合来增强 SIRT2 抑制作用
期刊:RSC Medicinal Chemistry
影响因子:3.6
doi:10.1039/d5md00144g
Wirawan Ricky, Frei Matthias, Heider Anna, Papenkordt Niklas, Friedrich Florian, Wein Thomas, Jung Manfred, Groll Michael, Huber Eva M, Bracher Franz
