日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A phase I study targeting the APE1/Ref-1 redox signaling protein with APX3330: first clinical agent targeting APE1/Ref-1 in cancer

APX3330 靶向 APE1/Ref-1 氧化还原信号蛋白的 I 期研究:首个靶向 APE1/Ref-1 的癌症临床药物

Kelley, Mark R; Wan, Jun; Liu, Sheng; Kpenu, Eyram; Wireman, Randall; Mosley, Amber L; Liu, Hao; Lakhani, Nehal J; Shahda, Safi; O'Neil, Bert; Opyrchal, Mateusz; Messmann, Richard A

The absence of Peroxiredoxin-1 in human pancreatic ductal adenocarcinoma (PDAC) markedly reduces cell survival and tumor growth when coupled with the inhibition of Ref-1 redox signaling.

人类胰腺导管腺癌 (PDAC) 中过氧化物酶-1 的缺失,与 Ref-1 氧化还原信号的抑制相结合,会显著降低细胞存活率和肿瘤生长。

Kiran Sonia, Wireman Randall S, Peil Jacqueline, Mitchell Dana K, Potchanant Elizabeth Sierra, Rai Ratan, Vilseck Jonah Z, Cao Sha, Haiaty Sanya, Georgiadis Millie M, Fishel Melissa L, Kelley Mark R

The MR1/MAIT cell axis impacts the gut-brain axis through both cognition and microbial community structure in 5XFAD mice

在5XFAD小鼠中,MR1/MAIT细胞轴通过认知和微生物群落结构影响肠-脑轴。

Wyatt-Johnson, Season K; Desai, Jay M; Wireman, Autumn; Eipers, Peter; Morrow, Casey; Vornhagen, Jay; Brutkiewicz, Randy R

Complete High Thoracic Spinal Cord Injury Causes Bowel Dysfunction in Mice

小鼠完全性高位胸段脊髓损伤导致肠道功能障碍

Wireman, Olivia H; Sams, Ellie L; Richey, Lynnet E; Hammers, Gabrielle V; Stewart, Andrew N; Bailey, William M; Patel, Samir P; Gensel, John C

Targeting APE1 endonuclease activity impairs metastasis and enhances genotoxic therapy response in pancreatic cancer

靶向APE1核酸内切酶活性可抑制胰腺癌转移并增强基因毒性疗法的疗效

Kpenu, Eyram K; Mijiti, Mahmut; Gampala, Silpa; Wan, Jun; Liu, Sheng; Wireman, Randall S; Peil, Jacqueline; Mitchell, Dana K; Haiaty, Sanya; Sardar, Rajesh; Sharma, Akanksha; Georgiadis, Millie M; Fishel, Melissa L; Kelley, Mark R

In vitro and In vivo evidence demonstrating chronic absence of Ref-1 Cysteine 65 impacts Ref-1 folding configuration, redox signaling, proliferation and metastasis in pancreatic cancer

体外和体内证据表明 Ref-1 半胱氨酸 65 的长期缺失会影响胰腺癌中的 Ref-1 折叠结构、氧化还原信号、增殖和转移

M Mijit, E Kpenu, N N Chowdhury, S Gampala, R Wireman, S Liu, O Babb, M M Georgiadis, J Wan, M L Fishel, M R Kelley

New Ref-1/APE1 targeted inhibitors demonstrating improved potency for clinical applications in multiple cancer types

新型 Ref-1/APE1 靶向抑制剂在多种癌症类型的临床应用中表现出更高的疗效

Silpa Gampala, Hye-Ran Moon, Randall Wireman, Jacqueline Peil, Sonia Kiran, Dana K Mitchell, Kylee Brewster, Henry Mang, Andi Masters, Christine Bach, Whitney Smith-Kinnamen, Emma H Doud, Ratan Rai, Amber L Mosley, Sara K Quinney, D Wade Clapp, Chafiq Hamdouchi, James Wikel, Chi Zhang, Bumsoo Han, M

PTEN knockout using retrogradely transported AAVs transiently restores locomotor abilities in both acute and chronic spinal cord injury

使用逆行运输的 AAV 敲除 PTEN 可暂时恢复急性和慢性脊髓损伤中的运动能力

Andrew N Stewart, Reena Kumari, William M Bailey, Ethan P Glaser, Christopher C Bosse-Joseph, Kennedy A Park, Gabrielle V Hammers, Olivia H Wireman, John C Gensel

PTEN knockout using retrogradely transported AAVs restores locomotor abilities in both acute and chronic spinal cord injury

使用逆行运输的 AAV 敲除 PTEN 可恢复急性和慢性脊髓损伤患者的运动能力

Andrew N Stewart, Reena Kumari, William M Bailey, Ethan P Glaser, Gabrielle V Hammers, Olivia H Wireman, John C Gensel

Correction: Exploring transcriptional regulators Ref-1 and STAT3 as therapeutic targets in malignant peripheral nerve sheath tumours

更正:探索转录调控因子 Ref-1 和 STAT3 作为恶性周围神经鞘瘤的治疗靶点

Gampala, Silpa; Shah, Fenil; Zhang, Chi; Rhodes, Steven D; Babb, Olivia; Grimard, Michelle; Wireman, Randall S; Rad, Ellie; Calver, Brian; Bai, Ren-Yuan; Staedtke, Verena; Hulsey, Emily L; Saadatzadeh, M Reza; Pollok, Karen E; Tong, Yan; Smith, Abbi E; Clapp, D Wade; Tee, Andrew R; Kelley, Mark R; Fishel, Melissa L