日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Clinical, imaging and blood biomarker outcomes in a Phase 3 clinical trial of tau aggregation inhibitor hydromethylthionine mesylate in mild cognitive impairment and mild to moderate dementia due to Alzheimer's disease

一项针对轻度认知障碍和阿尔茨海默病引起的轻度至中度痴呆的tau蛋白聚集抑制剂甲磺酸氢甲基硫氨酸的3期临床试验的临床、影像学和血液生物标志物结果

Wischik, Claude M; Stefanacci, Richard; Bentham, Peter; Gauthier, Serge; Zetterberg, Henrik; Wilcock, Gordon K; Froelich, Lutz; Burns, Alistair; MacSweeney, Emer; Ballard, Clive; Yu, Jin-Tai; Choon, Tay Siew; Asvatourian, Vahe; Muehlemann, Natalia; Priel, Jan; Kook, Karin; Sullivan, Tenecia; Downie, Diane; Miller, Sonya; Pringle, Carol; Storey, John M D; Baddeley, Tom; Harrington, Charles R; Penny, Lewis K; Arastoo, Mohammad; Staff, Roger; Sandu, Anca-Larisa; Shiells, Helen; Lo, Serena; Nazlee, Nafeesa; Evans, Emily; Hull, Claire; Schelter, Bjoern O

Timing matters: early administration of a high-affinity antibody targeting the tau repeat domain prevents aggregation in a mouse tauopathy model

时机至关重要:在小鼠tau蛋白病模型中,早期注射靶向tau重复结构域的高亲和力抗体可预防聚集。

Penny, Lewis K; Arastoo, Mohammad; Lofthouse, Richard; Abdallah, Aya; Imoesi, Peter I; Schwab, Karima; Shiells, Helen; Melis, Valeria; Riedel, Gernot; Harrington, Charles R; Wischik, Claude M; Porter, Andrew; Palliyil, Soumya

Inhibiting Disulfide Bonding in Truncated Tau297-391 Results in Enhanced Self-Assembly of Tau into Seed-Competent Assemblies

抑制截短的Tau297-391中的二硫键形成可增强Tau蛋白自组装成具有种子形成能力的复合物。

Oakley, Sebastian S; Marshall, Karen E; Meisl, Georg; Copsey, Alice; Maina, Mahmoud B; Milton, Robert; Vorley, Thomas; Storey, John M D; Harrington, Charles R; Wischik, Claude M; Xue, Wei-Feng; Serpell, Louise C

Effects of hydromethylthionine mesylate and rivastigmine in a pharmacological mouse model of Alzheimer's disease

氢甲基硫氨酸甲磺酸盐和利伐斯的明对阿尔茨海默病药理学小鼠模型的影响

Robinson, Lianne; Bray, Jack; Melis, Valeria; Harrington, Charles R; Wischik, Claude M; Riedel, Gernot

Role of (18)F-florzolotau PET in diagnostic and therapeutic decision-making for cognitive impairment

(18)F-florzolotau PET在认知障碍诊断和治疗决策中的作用

Wang, Jun; Wang, Zi-Yi; Chen, Shu-Fen; Wang, Rong-Ze; Chen, Ke-Liang; Lu, Jia-Ying; Xin, Jia-Wei; Huang, Yu-Yuan; Wang, Ming-Yu; Xie, Fang; Cheng, Wei; Yen, Tzu-Chen; Wischik, Claude M; Cui, Mei; Zuo, Chuan-Tao; Zhao, Qian-Hua; Wang, Yan-Jiang; Yu, Jin-Tai

Hydromethylthionine sustains truncated tau-dependent inflammation-lowering effects in mouse brain.

氢甲基硫氨酸在小鼠脑中维持截短的 tau 依赖性炎症降低作用

Santos Renato X, Lee Sophie H, Lofthouse Richard, Melis Valeria, Robinson Lianne, Leith Michael, Dreesen Eline, Armstrong Paul, Vorley Thomas, Goatman Elizabeth A, Hull Claire, Riedel Gernot, Wischik Claude M, Harrington Charles R

Quantification of plasma tau species containing the proline-rich region as a biomarker in Alzheimer's disease.

血浆中含有富含脯氨酸区域的 tau 蛋白种类的定量分析,作为阿尔茨海默病的生物标志物。

Arastoo Mohammad, Penny Lewis K, Lofthouse Richard, Hitchcock Aaron, Moelders Anna, Szalma Sona, Porter Andrew, Palliyil Soumya, Harrington Charles R, Wischik Claude M

Proteomic and non-proteomic changes of presynaptic proteins in animal models of Alzheimer's disease: A meta-analysis 2015-2023

阿尔茨海默病动物模型中突触前蛋白的蛋白质组学和非蛋白质组学变化:2015-2023 年荟萃分析

Anschuetz, Anne; Schwab, Karima; Harrington, Charles R; Wischik, Claude M; Riedel, Gernot

Neurofilament light (NfL) chain levels predict clinical decline in Alzheimer's disease: A systematic review and meta-analysis

神经丝轻链(NfL)水平可预测阿尔茨海默病临床症状的恶化:系统评价和荟萃分析

Thomas, Kim; Spin, Paul; Sir, Nikita; Hou, Kevin; Ashton, Nicholas J; Zetterberg, Henrik; Miller, Sonya; Pringle, Carol; Stefanacci, Richard; Wischik, Claude M; Gauthier, Serge

Considerations for biomarker strategies in clinical trials investigating tau-targeting therapeutics for Alzheimer's disease

针对阿尔茨海默病tau蛋白靶向疗法的临床试验中生物标志物策略的考量

Penny, Lewis K; Lofthouse, Richard; Arastoo, Mohammad; Porter, Andy; Palliyil, Soumya; Harrington, Charles R; Wischik, Claude M