日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Phenylhydrazone-based endoplasmic reticulum proteostasis regulator compounds with enhanced biological activity.

具有增强生物活性的苯腙类内质网蛋白稳态调节化合物。

Kline Gabriel M, Boinon Lisa, Guerrero Adrian, Kutseikin Sergei, Cruz Gabrielle, Williams Marnie P, Paxman Ryan J, Balch William E, Kelly Jeffery W, Mu Tingwei, Wiseman R Luke

DM: a simple solution to suppress air-water interface interactions in cryo-EM

DM:一种抑制冷冻电镜中气-水界面相互作用的简单方法

Rafiq, Maria; Schäfer, Jan-Hannes; Rahmani, Hamidreza; You, Shaochen; Bollong, Michael; Grotjahn, Danielle; Wiseman, R Luke; Lander, Gabriel C

Pharmacological targeting of RIG-I can selectively activate the integrated stress response

通过药物靶向RIG-I可以选择性地激活整合应激反应。

Cuoco, Caroline A; Ren, Wen; Baron, Kelsey R; Gologo, Sakina; Perea, Valerie; Mathur, Prakhyat; Bora, Prerona; Ta, Amina; Chu, Alan; Aldakhlallah, Rama; Rhoades, Derek; Cole, Christian M; Tan, Ee Phie; Hou, William C; Yoon, Leonard; Guo, Xiaoyan; Rosarda, Jessica D; Baran, Phil S; Kampmann, Martin; Tillery, Lakeisha; Johnson, Kristen A; Powers, Evan T; Wiseman, R Luke; Kelly, Jeffery W

Activation of XBP1s attenuates disease severity in models of proteotoxic Charcot-Marie-Tooth type 1B

XBP1s 的激活可减轻蛋白毒性夏科-马里-图斯病 1B 型模型中的疾病严重程度。

Touvier, Thierry; Veneri, Francesca A; Claessens, Anke; Ferri, Cinzia; Mastrangelo, Rosa; Sorgiati, Noémie; Bianchi, Francesca; Valenzano, Serena; Del Carro, Ubaldo; Rivellini, Cristina; Duong, Phu; Shy, Michael E; Kelly, Jeffery W; Svaren, John; Wiseman, R Luke; D'Antonio, Maurizio

Drug repurposing screen identifies an HRI activating compound that promotes adaptive mitochondrial remodeling in MFN2-deficient cells.

药物再利用筛选发现了一种 HRI 激活化合物,该化合物可促进 MFN2 缺陷细胞中的线粒体适应性重塑。

Bora Prerona, Zaman Mashiat, Oviedo Samantha, Kutseikin Sergei, Madrazo Nicole, Mathur Prakhyat, Pannikkat Meera, Krasny Sophia, Aldakhlallah Rama, Chu Alan, Johnson Kristen A, Grotjahn Danielle A, Shutt Timothy E, Wiseman R Luke

Pharmacologic activation of integrated stress response kinases inhibits pathologic mitochondrial fragmentation.

整合应激反应激酶的药理学激活可抑制病理性线粒体碎片化

Baron Kelsey R, Oviedo Samantha, Krasny Sophia, Zaman Mashiat, Aldakhlallah Rama, Bora Prerona, Mathur Prakhyat, Pfeffer Gerald, Bollong Michael J, Shutt Timothy E, Grotjahn Danielle A, Wiseman R Luke

AA147 Alleviates Symptoms in a Mouse Model of Multiple Sclerosis by Reducing Oligodendrocyte Loss.

AA147 通过减少少突胶质细胞丢失来缓解多发性硬化症小鼠模型的症状

Aksu Metin, Kaschke Kevin, Podojil Joseph R, Chiang MingYi, Steckler Ian, Bruce Kody, Cogswell Andrew C, Schulz Gwen, Kelly Jeffery W, Wiseman R Luke, Miller Stephen D, Popko Brian, Chen Yanan

Improving Proteostasis of Trafficking-Deficient GABA(A) Receptor Variants by Activating IRE1.

通过激活 IRE1 改善转运缺陷 GABA(A) 受体变体的蛋白质稳态。

Fu Xu, Wang Ya-Juan, Lee KyungA, Ahn Lucie Y, Chen Xi, Harvey Brock T, Wang Meng, Seibert Hailey, Zhang Pei-Pei, Guerrero Adrian, Schaffer Ashleigh E, Richards Christopher I, Wiseman R Luke, Kelly Jeffery W, Mu Ting-Wei

Identification of a Selective Pharmacologic IRE1/XBP1s Activator with Enhanced Tissue Exposure.

鉴定一种具有增强组织暴露的选择性药理学IRE1/XBP1s激活剂。

Sun Jie, Lee Kyunga, Kutseikin Sergei, Guerrero Adrian, Rius Bibiana, Madhavan Aparajita, Buasakdi Chavin, Cheong Ka-Neng, Chatterjee Priyadarshini, Rosen Dorian A, Yoon Leonard, Ardejani Maziar S, Mendoza Alejandra, Rosarda Jessica D, Saez Enrique, Kelly Jeffery W, Wiseman R Luke

Optimizing PDIA1 Inhibition as a Strategy to Inhibit NLRP3 Inflammasome Activation and Activity.

优化 PDIA1 抑制作为抑制 NLRP3 炎症小体激活和活性的策略

Buasakdi Chavin, Stanton Caroline R, Bora Prerona, Chatterjee Priyadarshini, Bollong Michael J, Wiseman R Luke