Allosteric SHP2 inhibition increases apoptotic dependency on BCL2 and synergizes with venetoclax in FLT3- and KIT-mutant AML
变构SHP2抑制增强了细胞凋亡对BCL2的依赖性，并与维奈托克在FLT3和KIT突变型急性髓系白血病中产生协同作用。
期刊:Cell Reports Medicine
影响因子:11.7
doi:10.1016/j.xcrm.2023.101290
Bogdan Popescu,Carlos Stahlhut,Theodore C Tarver,Sydney Wishner,Bianca J Lee,Cheryl A C Peretz,Cuyler Luck,Paul Phojanakong,Juan Antonio Camara Serrano,Henry Hongo,Jose M Rivera,Simayijiang Xirenayi,John A Chukinas,Veronica Steri,Sarah K Tasian,Elliot Stieglitz,Catherine C Smith
白血病
细胞生物学
表观遗传
BCL2
KIT
FLT3
凋亡
