日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of small molecule modulators of the thin filament that alter the contractile profile in a hypertrophic cardiomyopathy engineered tissue model

在肥厚型心肌病工程组织模型中,发现了能够改变细丝收缩特性的小分子调节剂

Sommese, Ruth F; Levi, Samuel M; Brown, Janice; Polivkova, Jana; Byrnes, Laura J; Kue, Richard; Damilano, Federico; Hua, Wenyi; Boehm, Markus; Dushin, Elizabeth; Filipski, Kevin J; Kormos, Bethany L; Li, Qifang; Miller, Russell; Ogilvie, Kevin; Ridgway, Noelle; Smith, Aaron C; Stansfield, John C; Wang, Yang; Withka, Jane; Zhang, Hui; Griffith, David A; Ward, Jessica

Intramolecular Ring-Opening Decomposition of Aryl Azetidines

芳基氮杂环丁烷的分子内开环分解

Bai, Guoyun; O'Connell, Thomas N; Brodney, Michael A; Butler, Christopher R; Czabaniuk, Lara C; Gilbert, Adam M; LaChapelle, Erik A; Li, Chao; McAllister, Laura A; Ogilvie, Kevin; Philippe, Laurence; Salomon-Ferrer, Romelia; Shapiro, Michael J; Starr, Jeremy T; Uccello, Daniel P; Withka, Jane M; Yan, Jiangli; Brown, Matthew F

Design, Optimization, and Study of Small Molecules That Target Tau Pre-mRNA and Affect Splicing

针对 Tau Pre-mRNA 并影响剪接的小分子的设计、优化和研究

Jonathan L Chen, Peiyuan Zhang, Masahito Abe, Haruo Aikawa, Liying Zhang, Alexander J Frank, Timothy Zembryski, Christopher Hubbs, HaJeung Park, Jane Withka, Claire Steppan, Lucy Rogers, Shawn Cabral, Martin Pettersson, Travis T Wager, Matthew A Fountain, Gavin Rumbaugh, Jessica L Childs-Disney, Mat

Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy

6-氯-5-[4-(1-羟基环丁基)苯基]-1H-吲哚-3-羧酸 (PF-06409577) 的发现和临床前表征,它是腺苷酸活化蛋白激酶 (AMPK) 的直接激活剂,可用于治疗糖尿病肾病

Kimberly O Cameron, Daniel W Kung, Amit S Kalgutkar, Ravi G Kurumbail, Russell Miller, Christopher T Salatto, Jessica Ward, Jane M Withka, Samit K Bhattacharya, Markus Boehm, Kris A Borzilleri, Janice A Brown, Matthew Calabrese, Nicole L Caspers, Emily Cokorinos, Edward L Conn, Matthew S Dowling, Da

Probing the enzyme kinetics, allosteric modulation and activation of α1- and α2-subunit-containing AMP-activated protein kinase (AMPK) heterotrimeric complexes by pharmacological and physiological activators

探索酶动力学、变构调节以及药理和生理激活剂对含有 α1 和 α2 亚基的 AMP 活化蛋白激酶 (AMPK) 异三聚体复合物的激活

Francis Rajamohan, Allan R Reyes, Richard K Frisbie, Lise R Hoth, Parag Sahasrabudhe, Rachelle Magyar, James A Landro, Jane M Withka, Nicole L Caspers, Matthew F Calabrese, Jessica Ward, Ravi G Kurumbail

Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists

大环IL-17A拮抗剂的结合位点阐明和结构导向设计

Shenping Liu ,Leslie A Dakin ,Li Xing ,Jane M Withka ,Parag V Sahasrabudhe ,Wei Li ,Mary Ellen Banker ,Paul Balbo ,Suman Shanker ,Boris A Chrunyk ,Zuojun Guo ,Jinshan M Chen ,Jennifer A Young ,Guoyun Bai ,Jeremy T Starr ,Stephen W Wright ,Joerg Bussenius ,Sheng Tan ,Ariamala Gopalsamy ,Bruce A Lefker ,Fabien Vincent ,Lyn H Jones ,Hua Xu ,Lise R Hoth ,Kieran F Geoghegan ,Xiayang Qiu ,Mark E Bunnage ,Atli Thorarensen

SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1

SRT1720、SRT2183、SRT1460 和白藜芦醇不是 SIRT1 的直接激活剂

Michelle Pacholec, John E Bleasdale, Boris Chrunyk, David Cunningham, Declan Flynn, Robert S Garofalo, David Griffith, Matt Griffor, Pat Loulakis, Brandon Pabst, Xiayang Qiu, Brian Stockman, Venkataraman Thanabal, Alison Varghese, Jessica Ward, Jane Withka, Kay Ahn