Autoantibodies from patients with kidney allograft vasculopathy stimulate a proinflammatory switch in endothelial cells and monocytes mediated via GPCR-directed PAR1-TNF-α signaling
肾移植血管病变患者的自身抗体通过GPCR介导的PAR1-TNF-α信号通路,刺激内皮细胞和单核细胞发生促炎性转变。
期刊:Frontiers in Immunology
影响因子:5.9
doi:10.3389/fimmu.2023.1289744
Moll, Guido; Luecht, Christian; Gyamfi, Michael Adu; da Fonseca, Dennyson L M; Wang, Pinchao; Zhao, Hongfan; Gong, Zexian; Chen, Lei; Ashraf, Muhamad Imtiaz; Heidecke, Harald; Hackel, Alexander Maximilian; Dragun, Duska; Budde, Klemens; Penack, Olaf; Riemekasten, Gabriela; Cabral-Marques, Otávio; Witowski, Janusz; Catar, Rusan
信号转导
TNF-α
内皮细胞
单核细胞
GPCR/Calcium/cAMP
细胞生物学
免疫/内分泌