日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Integrative Multiomics and Drug Sensitivity Profiling Reveal Potential Biomarkers and Therapeutic Strategies in Pediatric Solid Tumors

整合多组学和药物敏感性分析揭示儿童实体瘤的潜在生物标志物和治疗策略

ElHarouni, Dina; Hernansaiz-Ballesteros, Rosa; Peterziel, Heike; Balasubramanian, Gnana Prakash; Previti, Christopher; Schramm, Kathrin; Blattner-Johnson, Mirjam; Kabbe, Rolf; Jones, Barbara C; Oppermann, Sina; Jones, David T W; Pfister, Stefan M; Witt, Olaf; Saez-Rodriguez, Julio; Oehme, Ina; Jäger, Natalie; Schlesner, Matthias

Mutated FGFR1 is an oncogenic driver and therapeutic target in high-risk neuroblastoma

突变的FGFR1是高危神经母细胞瘤的致癌驱动因素和治疗靶点。

Werr, Lisa; Boland, Jana; Petersen, Josephine; Iglesias, Fiorella; Höppner, Stefanie; Bartenhagen, Christoph; Rosswog, Carolina; Hellmann, Anna-Maria; Kahlert, Yvonne; Hemstedt, Nadine; Ibruli, Nadliv; Dammert, Marcel A; Decarolis, Boris; Werner, Jan-Michael; Malchers, Florian; Schramm, Kathrin; Witt, Olaf; Beiske, Klaus H; Rognlien, Anne Gro Wesenberg; Gunnes, Maria Winther; Langenberg, Karin P; Molenaar, Jan; Bernkopf, Marie; Taschner-Mandl, Sabine; Hughes, Debbie; George, Sally L; Chesler, Louis; Schulte, Johannes H; Barone, Giuseppe; Capasso, Mario; Surrey, Lea F; Bagatell, Rochelle; Masliah-Planchon, Julien; Schleiermacher, Gudrun; Grüll, Holger; Westermann, Frank; Schultheis, Anne M; Büttner, Reinhard; Henssen, Anton G; Eggert, Angelika; Peifer, Martin; Shukla, Neerav N; Simon, Thorsten; Hero, Barbara; Reinhardt, H Christian; Thomas, Roman K; Fischer, Matthias

Preclinical drug screen identifies WEE1 inhibitor and vinca alkaloid as a combination treatment concept for Li-Fraumeni syndrome medulloblastoma.

临床前药物筛选发现 WEE1 抑制剂和长春花生物碱可作为李-弗劳梅尼综合征髓母细胞瘤的联合治疗方案。

Kolodziejczak Anna S, Selt Florian, Peterziel Heike, Jamaladdin Nora, Mack Norman, Maaß Kendra, Meulenbroeks Chris, Sigaud Romain, Herold-Mende Christel, El Damaty Ahmed, Burhenne Jürgen, Ohmura Shunya, Holland-Letz Tim, Kutscher Lena M, Ernst Aurélie, Wei Pei-Chi, Grünewald Thomas G P, Oehme Ina, Kool Marcel, Jones David T W, Pajtler Kristian W, Kratz Christian P, Pfister Stefan M, Witt Olaf, Milde Till

Multi-omics dissection of MAPK-driven senescence unveils therapeutic vulnerabilities in KIAA1549::BRAF-fusion pediatric low-grade glioma models.

多组学分析 MAPK 驱动的衰老揭示了 KIAA1549::BRAF 融合儿童低级别胶质瘤模型的治疗弱点

Sigaud Romain, Stefanski Anja, Selt Florian, Kocher Daniela, Usta Diren, Picard Daniel, Büdenbender Isabel, Remke Marc, Pfister Stefan M, Jones David T W, Brummer Tilman, Witt Olaf, Milde Till

Author Correction: The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trial

作者更正:II型RAF抑制剂托沃拉非尼治疗复发/难治性儿童低级别胶质瘤:FIREFLY-1 II期试验

Kilburn, Lindsay B; Khuong-Quang, Dong-Anh; Hansford, Jordan R; Landi, Daniel; van der Lugt, Jasper; Leary, Sarah E S; Driever, Pablo Hernáiz; Bailey, Simon; Perreault, Sébastien; McCowage, Geoffrey; Waanders, Angela J; Ziegler, David S; Witt, Olaf; Baxter, Patricia A; Kang, Hyoung Jin; Hassall, Timothy E; Han, Jung Woo; Hargrave, Darren; Franson, Andrea T; Yalon Oren, Michal; Toledano, Helen; Larouche, Valérie; Kline, Cassie; Abdelbaki, Mohamed S; Jabado, Nada; Gottardo, Nicholas G; Gerber, Nicolas U; Whipple, Nicholas S; Segal, Devorah; Chi, Susan N; Oren, Liat; Tan, Enrica E K; Mueller, Sabine; Cornelio, Izzy; McLeod, Lisa; Zhao, Xin; Walter, Ashley; Da Costa, Daniel; Manley, Peter; Blackman, Samuel C; Packer, Roger J; Nysom, Karsten

Oncogene aberrations drive medulloblastoma progression, not initiation

癌基因异常驱动髓母细胞瘤的进展,而非起始。

Okonechnikov, Konstantin; Joshi, Piyush; Körber, Verena; Rademacher, Anne; Bortolomeazzi, Michele; Mallm, Jan-Philipp; Vaillant, Jan; da Silva, Patricia Benites Goncalves; Statz, Britta; Sepp, Mari; Sarropoulos, Ioannis; Yamada, Tetsuya; Wittmann, Andrea; Schramm, Kathrin; Blattner-Johnson, Mirjam; Fiesel, Petra; Jones, Barbara; Jäger, Natalie; Milde, Till; Pajtler, Kristian W; van Tilburg, Cornelis M; Witt, Olaf; Bochennek, Konrad; Weber, Katharina Johanna; Nonnenmacher, Lisa; Reimann, Christian; Ghasemi, David R; Schüller, Ulrich; Mynarek, Martin; Rutkowski, Stefan; Jones, David T W; Korshunov, Andrey; Rippe, Karsten; Westermann, Frank; Thongjuea, Supat; Höfer, Thomas; Kaessmann, Henrik; Kutscher, Lena M; Pfister, Stefan M

Author Correction: A diverse landscape of FGFR alterations and co-mutations suggests potential therapeutic strategies in pediatric low-grade gliomas

作者更正:FGFR 改变和共突变的多样性提示了儿童低级别胶质瘤的潜在治疗策略。

Apfelbaum, April A; Morin, Eric; Sturm, Dominik; Ayoub, Georges; DiGiacomo, Jeromy; Bahadur, Sher; Chandarana, Bhavyaa; Power, Phoebe C; Cusick, Margaret M; Novikov, Dana; Prabhakar, Prem; Jones, Robert E; Vogelzang, Jayne; Bossi, Connor C; Malinowski, Seth; Woodward, Lewis M; Jones, Tania A; Jeang, John; Lamson, Sarah W; Collins, Jared; Cai, Kelly Y; Jones, Jacquelyn S; Oh, Sehee; Jeon, Hyesung; Wang, Jinhua; Cameron, Amy; Rechter, Patrick; De Leon, Angela; Murugesan, Karthikeyan; Montesion, Meagan; Albacker, Lee A; Ramkissoon, Shakti H; van Tilburg, Cornelis M; Hardin, Emily C; Sievers, Philipp; Sahm, Felix; Yeo, Kee Kiat; Rosenberg, Tom; Chi, Susan N; Wright, Karen D; Hébert, Steven; Peck, Sydney; Picca, Alberto; Larouche, Valérie; Renzi, Samuele; Buhrlage, Sara J; Bale, Tejus A; Smith, Amy A; Touat, Mehdi; Jabado, Nada; Fischer, Eric S; Eck, Michael J; Baird, Lissa; Witt, Olaf; Kleinman, Claudia L; Nguyen, Quang-De; Sheer, Denise; Alexandrescu, Sanda; Jones, David T W; Ligon, Keith L; Bandopadhayay, Pratiti

A diverse landscape of FGFR alterations and co-mutations suggests potential therapeutic strategies in pediatric low-grade gliomas.

FGFR 改变和共突变的多样性提示了儿童低级别胶质瘤的潜在治疗策略

Apfelbaum April A, Morin Eric, Sturm Dominik, Ayoub Georges, DiGiacomo Jeromy, Bahadur Sher, Chandarana Bhavyaa, Power Phoebe C, Cusick Margaret M, Novikov Dana, Prabhakar Prem, Jones Robert E, Vogelzang Jayne, Bossi Connor C, Malinowski Seth, Woodward Lewis M, Jones Tania A, Jeang John, Lamson Sarah W, Collins Jared, Cai Kelly Y, Jones Jacquelyn S, Oh Sehee, Jeon Hyesung, Wang Jinhua, Cameron Amy, Rechter Patrick, De Leon Angela, Murugesan Karthikeyan, Montesion Meagan, Albacker Lee A, Ramkissoon Shakti H, van Tilburg Cornelis M, Hardin Emily C, Sievers Philipp, Sahm Felix, Yeo Kee Kiat, Rosenberg Tom, Chi Susan N, Wright Karen D, Hébert Steven, Peck Sydney, Picca Alberto, Larouche Valérie, Renzi Samuele, Buhrlage Sara J, Bale Tejus A, Smith Amy A, Touat Mehdi, Jabado Nada, Fischer Eric S, Eck Michael J, Baird Lissa, Witt Olaf, Kleinman Claudia L, Nguyen Quang-De, Sheer Denise, Alexandrescu Sanda, Jones David T W, Ligon Keith L, Bandopadhayay Pratiti

High 4E-BP1 expression associates with chromosome 8 gain and CDK4/6 sensitivity in Ewing sarcoma

尤文氏肉瘤中高表达的 4E-BP1 与 8 号染色体扩增和 CDK4/6 敏感性相关

Funk, Cornelius M; Ehlers, Anna C; Orth, Martin F; Aljakouch, Karim; Li, Jing; Hölting, Tilman Lb; Will, Rainer; Geyer, Florian H; Ceranski, A Katharina; Willis, Franziska; Vinca, Endrit; Ohmura, Shunya; Imle, Roland; Siebenlist, Jana; Yershova, Angelina; Knott, Maximilian Ml; Zahnow, Felina; Sastre, Ana; Alonso, Javier; Sahm, Felix; Peterziel, Heike; Loboda, Anna; Schneider, Martin; Banito, Ana; Leprivier, Gabriel; Hartmann, Wolfgang; Dirksen, Uta; Witt, Olaf; Oehme, Ina; Pfister, Stefan M; Romero-Pérez, Laura; Krijgsveld, Jeroen; Cidre-Aranaz, Florencia; Grünewald, Thomas Gp; Musa, Julian

Radiographic and visual response to the type II RAF inhibitor tovorafenib in children with relapsed/refractory optic pathway glioma in the FIREFLY-1 trial

FIREFLY-1试验中,复发/难治性视路胶质瘤患儿对II型RAF抑制剂托沃拉非尼的放射学和视觉反应

Nysom, Karsten; Kilburn, Lindsay B; Leary, Sarah E S; Landi, Daniel B; de Vos-Kerkhof, Evelien; Perreault, Sébastien; Witt, Olaf; Ziegler, David S; Hernáiz Driever, Pablo; Franson, Andrea T; Baxter, Patricia A; Whipple, Nicholas S; Kline, Cassie; Segal, Devorah; Jabado, Nada; Bailey, Simon; McCowage, Geoffrey; Hansford, Jordan R; Khuong-Quang, Dong-Anh; Gottardo, Nicholas G; Hassall, Timothy; Han, Jung Woo; Yalon Oren, Michal; Chi, Susan N; Qiu, Jiaheng; Da Costa, Daniel; Govinda Raju, Sandya; Manley, Peter; Hargrave, Darren