日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Genome-wide analyses identify 25 infertility loci and relationships with reproductive traits across the allele frequency spectrum

全基因组分析鉴定出25个不孕症基因位点,并揭示了这些位点与等位基因频率范围内生殖性状的关联。

Venkatesh, Samvida S; Wittemans, Laura B L; Palmer, Duncan S; Baya, Nikolas A; Ferreira, Teresa; Hill, Barney; Lassen, Frederik Heymann; Parker, Melody J; Reibe, Saskia; Elhakeem, Ahmed; Banasik, Karina; Bruun, Mie T; Erikstrup, Christian; Aagard Jensen, Bitten; Juul, Anders; Mikkelsen, Christina; Nielsen, Henriette S; Ostrowski, Sisse R; Pedersen, Ole B; Rohde, Palle Duun; Sørensen, Erik; Ullum, Henrik; Westergaard, David; Haraldsson, Asgeir; Holm, Hilma; Jonsdottir, Ingileif; Olafsson, Isleifur; Steingrimsdottir, Thora; Steinthorsdottir, Valgerdur; Thorleifsson, Gudmar; Figueredo, Jessica; Karjalainen, Minna K; Pasanen, Anu; Jacobs, Benjamin M; Kalantzis, Georgios; Hubers, Nikki; Lippincott, Margaret; Fraser, Abigail; Lawlor, Deborah A; Timpson, Nicholas J; Nyegaard, Mette; Stefansson, Kari; Magi, Reedik; Laivuori, Hannele; van Heel, David A; Boomsma, Dorret I; Balasubramanian, Ravikumar; Seminara, Stephanie B; Chan, Yee-Ming; Laisk, Triin; Lindgren, Cecilia M

Characterising the genetic architecture of changes in adiposity during adulthood using electronic health records

利用电子健康记录来描述成年期脂肪含量变化的遗传结构

Venkatesh, Samvida S; Ganjgahi, Habib; Palmer, Duncan S; Coley, Kayesha; Linchangco, Gregorio V Jr; Hui, Qin; Wilson, Peter; Ho, Yuk-Lam; Cho, Kelly; Arumäe, Kadri; Wittemans, Laura B L; Nellåker, Christoffer; Vainik, Uku; Sun, Yan V; Holmes, Chris; Lindgren, Cecilia M; Nicholson, George

Genome-wide analyses identify 21 infertility loci and over 400 reproductive hormone loci across the allele frequency spectrum

全基因组分析在等位基因频率范围内鉴定出21个不孕症基因位点和400多个生殖激素基因位点。

Venkatesh, Samvida S; Wittemans, Laura B L; Palmer, Duncan S; Baya, Nikolas A; Ferreira, Teresa; Hill, Barney; Lassen, Frederik Heymann; Parker, Melody J; Reibe, Saskia; Elhakeem, Ahmed; Banasik, Karina; Bruun, Mie T; Erikstrup, Christian; Jensen, Bitten A; Juul, Anders; Mikkelsen, Christina; Nielsen, Henriette S; Ostrowski, Sisse R; Pedersen, Ole B; Rohde, Palle D; Sorensen, Erik; Ullum, Henrik; Westergaard, David; Haraldsson, Asgeir; Holm, Hilma; Jonsdottir, Ingileif; Olafsson, Isleifur; Steingrimsdottir, Thora; Steinthorsdottir, Valgerdur; Thorleifsson, Gudmar; Figueredo, Jessica; Karjalainen, Minna K; Pasanen, Anu; Jacobs, Benjamin M; Hubers, Nikki; Lippincott, Margaret; Fraser, Abigail; Lawlor, Deborah A; Timpson, Nicholas J; Nyegaard, Mette; Stefansson, Kari; Magi, Reedik; Laivuori, Hannele; van Heel, David A; Boomsma, Dorret I; Balasubramanian, Ravikumar; Seminara, Stephanie B; Chan, Yee-Ming; Laisk, Triin; Lindgren, Cecilia M

Large scale phenotype imputation and in vivo functional validation implicate ADAMTS14 as an adiposity gene

大规模表型推断和体内功能验证表明 ADAMTS14 是肥胖基因

Katherine A Kentistou, Jian'an Luan, Laura B L Wittemans, Catherine Hambly, Lucija Klaric, Zoltán Kutalik, John R Speakman, Nicholas J Wareham, Timothy J Kendall, Claudia Langenberg, James F Wilson, Peter K Joshi, Nicholas M Morton

OR20-01 Machine Learning-based Steroid Metabolome Analysis In Women With Polycystic Ovary Syndrome Reveals Three Distinct Androgen Excess Subtypes With Different Metabolic Risk Profiles

OR20-01 基于机器学习的多囊卵巢综合征女性类固醇代谢组分析揭示了三种具有不同代谢风险特征的雄激素过多亚型

Oppen, Kjersti; Brede, Cato; Skadberg, Øyvind; Steinsvik, Trude; Holter, Jan Cato; Michelsen, Annika E; Heggelund, Lars; Calimag, Angela Pauline; Tarabichi, Ula; Ahmad, Malikwaseem; Kazi, Mohammed; Wittayavimol, Nattamolphan; Iwabuchi, Erina; Pateetin, Prangwan; Miki, Yasuhiro; Onodera, Yoshiaki; Sasano, Hironobu; Boonyaratanakornkit, Viroj; Grant, Bonnie; Campbell, John; Pradeep, Anjali; Dawn Burns, Angela; Bassett, Paul; Saket, Priyadarshi; Minhas, Sukhbinder; Singh Dhillo, Waljit; McVeigh, James; Bhasin, Shalender; Nalin Jayasena, Channa; Krogh, Jesper; Plomgaard, Peter Stendahl; Frikke-Schmidt, Ruth; Velschow, Sten; Johannesen, Jesper; Hilsted, Linda; Schrøder, Malene; Feldt-Rasmussen, Ulla; Rocha, Thaís P; Melson, Eka; Veen, Roland J; Abdi, Lida; McDonnell, Tara; Tandl, Veronika; Hawley, James; Wittemans, Laura; Anthony, Amarah; Gilligan, Lorna; Shaheen, Fozia; Kempegowda, Punith; Gillett, Caroline D T; Cussen, Leanne; Missbrenner, Cornelia; Lajeunesse-Trempe, Fannie; Gleeson, Helena; Rees, Aled; Robinson, Lynne; Jayasenna, Channa; Randeva, Harpal S; Randeva, Harpal Singh; Dimitriadis, Georgios K; Gomes, Larissa G; Sitch, Alice; Vradi, Eleni; Taylor, Angela E; O'Reilly, Michael W; Obermayer-Pietsch, Barbara Maria; Biehl, Michael; Arlt, Wiebke

The genetic architecture of changes in adiposity during adulthood

成年期脂肪含量变化的遗传结构

Venkatesh, Samvida S; Ganjgahi, Habib; Palmer, Duncan S; Coley, Kayesha; Wittemans, Laura B L; Nellaker, Christoffer; Holmes, Chris; Lindgren, Cecilia M; Nicholson, George

Rare and common genetic determinants of metabolic individuality and their effects on human health

代谢个体差异的罕见和常见遗传决定因素及其对人类健康的影响

Surendran, Praveen; Stewart, Isobel D; Au Yeung, Victoria P W; Pietzner, Maik; Raffler, Johannes; Wörheide, Maria A; Li, Chen; Smith, Rebecca F; Wittemans, Laura B L; Bomba, Lorenzo; Menni, Cristina; Zierer, Jonas; Rossi, Niccolò; Sheridan, Patricia A; Watkins, Nicholas A; Mangino, Massimo; Hysi, Pirro G; Di Angelantonio, Emanuele; Falchi, Mario; Spector, Tim D; Soranzo, Nicole; Michelotti, Gregory A; Arlt, Wiebke; Lotta, Luca A; Denaxas, Spiros; Hemingway, Harry; Gamazon, Eric R; Howson, Joanna M M; Wood, Angela M; Danesh, John; Wareham, Nicholas J; Kastenmüller, Gabi; Fauman, Eric B; Suhre, Karsten; Butterworth, Adam S; Langenberg, Claudia

HOTAIR interacts with PRC2 complex regulating the regional preadipocyte transcriptome and human fat distribution

HOTAIR 与 PRC2 复合物相互作用,调节区域前脂肪细胞转录组和人体脂肪分布

Feng-Chih Kuo, Matt J Neville, Rugivan Sabaratnam, Agata Wesolowska-Andersen, Daniel Phillips, Laura B L Wittemans, Andrea D van Dam, Nellie Y Loh, Marijana Todorčević, Nathan Denton, Katherine A Kentistou, Peter K Joshi, Constantinos Christodoulides, Claudia Langenberg, Philippe Collas, Fredrik Kar

Evidence From Men for Ovary-independent Effects of Genetic Risk Factors for Polycystic Ovary Syndrome

来自男性的证据表明,多囊卵巢综合征的遗传风险因素存在卵巢非依赖性效应

Zhu, Jia; Pujol-Gualdo, Natàlia; Wittemans, Laura B L; Lindgren, Cecilia M; Laisk, Triin; Hirschhorn, Joel N; Chan, Yee-Ming

Identification of Rare Loss-of-Function Genetic Variation Regulating Body Fat Distribution

鉴定调节体脂分布的罕见功能丧失性遗传变异

Mine Koprulu, Yajie Zhao, Eleanor Wheeler, Liang Dong, Nuno Rocha, Chen Li, John D Griffin, Satish Patel, Marcel Van de Streek, Craig A Glastonbury, Isobel D Stewart, Felix R Day, Jian'an Luan, Nicholas Bowker, Laura B L Wittemans, Nicola D Kerrison, Lina Cai, Debora M E Lucarelli, Inês Barroso, Mar