日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Screening of the Pandemic Response Box Library Identified CRM1/XPO1 as an Anti-Mammarenavirus Druggable Target

对疫情应对库的筛选发现,CRM1/XPO1 是一个可作为抗哺乳动物沙粒病毒药物靶点的基因。

Ofodile, Chukwudi A; Cubitt, Beatrice; Onyemelukwe, Ngozi; Okwuanaso, Chetachi B; Witwit, Haydar; de la Torre, Juan C

Repurposing Drugs for Synergistic Combination Therapies to Counteract Monkeypox Virus Tecovirimat Resistance

利用药物再利用协同联合疗法对抗猴痘病毒替科维瑞特耐药性

Witwit, Haydar; Cubitt, Beatrice; Khafaji, Roaa; Castro, Esteban M; Goicoechea, Miguel; Lorenzo, Maria M; Blasco, Rafael; Martinez-Sobrido, Luis; de la Torre, Juan C

N-myristoyltransferase Inhibitors as Candidate Broad-Spectrum Antivirals to Treat Viral Infections Promoted by Immunosuppression Associated with JAK Inhibitors Therapy

N-肉豆蔻酰转移酶抑制剂作为治疗JAK抑制剂治疗相关免疫抑制所致病毒感染的候选广谱抗病毒药物

Witwit, Haydar; de la Torre, Juan Carlos

Pandemic Response Box Screening Identified CRM1/XPO1 as an Anti-Mammarenavirus Druggable Target

疫情应对筛选确定 CRM1/XPO1 为抗哺乳动物沙粒病毒药物靶点

Ofodile, Chukwudi A; Cubitt, Beatrice; Onyemelukwe, Ngozi; Okwuanaso, Chetachi B; Witwit, Haydar; de la Torre, Juan C

Mammarenavirus Z Protein Myristoylation and Oligomerization Are Not Required for Its Dose-Dependent Inhibitory Effect on vRNP Activity.

哺乳动物沙粒病毒 Z 蛋白的肉豆蔻酰化和寡聚化并非其对 vRNP 活性产生剂量依赖性抑制作用的必要条件

Witwit Haydar, de la Torre Juan C

Proximity interactome analysis of Lassa polymerase reveals eRF3a/GSPT1 as a druggable target for host-directed antivirals

拉沙病毒聚合酶的邻近相互作用组分析揭示 eRF3a/GSPT1 是宿主导向抗病毒药物的潜在靶点

Fang, Jingru; Pietzsch, Colette; Witwit, Haydar; Tsaprailis, George; Crynen, Gogce; Cho, Kelvin Frank; Ting, Alice Y; Bukreyev, Alexander; Saphire, Erica Ollmann; de la Torre, Juan Carlos

Inhibitors of Anti-apoptotic Bcl-2 Family Proteins Exhibit Potent and Broad-Spectrum Anti-mammarenavirus Activity via Cell Cycle Arrest at G0/G1 Phase

抗凋亡Bcl-2家族蛋白抑制剂通过G0/G1期细胞周期阻滞,表现出强效且广谱的抗哺乳动物沙粒病毒活性。

Kim, Yu-Jin; Witwit, Haydar; Cubitt, Beatrice; de la Torre, Juan C