日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Crystal structure of acetylcholinesterase catalytic subunits of the malaria vector Anopheles gambiae

疟疾媒介冈比亚按蚊乙酰胆碱酯酶催化亚基的晶体结构

Han, Qian; Wong, Dawn M; Robinson, Howard; Ding, Haizhen; Lam, Polo C H; Totrov, Maxim M; Carlier, Paul R; Li, Jianyong

TMEM175 deficiency impairs lysosomal and mitochondrial function and increases α-synuclein aggregation

TMEM175 缺乏会损害溶酶体和线粒体功能并增加 α-突触核蛋白聚集

Sarah Jinn, Robert E Drolet, Paige E Cramer, Andus Hon-Kit Wong, Dawn M Toolan, Cheryl A Gretzula, Bhavya Voleti, Galya Vassileva, Jyoti Disa, Marija Tadin-Strapps, David J Stone

Difluoromethyl ketones: Potent inhibitors of wild type and carbamate-insensitive G119S mutant Anopheles gambiae acetylcholinesterase

二氟甲基酮:冈比亚按蚊野生型和氨基甲酸酯不敏感型G119S突变体乙酰胆碱酯酶的强效抑制剂

Camerino, Eugene; Wong, Dawn M; Tong, Fan; Körber, Florian; Gross, Aaron D; Islam, Rafique; Viayna, Elisabet; Mutunga, James M; Li, Jianyong; Totrov, Maxim M; Bloomquist, Jeffrey R; Carlier, Paul R

Aryl methylcarbamates: potency and selectivity towards wild-type and carbamate-insensitive (G119S) Anopheles gambiae acetylcholinesterase, and toxicity to G3 strain An. gambiae.

芳基甲基氨基甲酸酯:对野生型和氨基甲酸酯不敏感(G119S)冈比亚按蚊乙酰胆碱酯酶的效力和选择性,以及对G3株冈比亚按蚊的毒性

Wong Dawn M, Li Jianyong, Lam Polo C H, Hartsel Joshua A, Mutunga James M, Totrov Maxim, Bloomquist Jeffrey R, Carlier Paul R

Neurotoxicology of bis(n)-tacrines on Blattella germanica and Drosophila melanogaster acetylcholinesterase

双(n)-他克林对德国小蠊和果蝇乙酰胆碱酯酶的神经毒理学研究

Mutunga, James M; Boina, Dhana Raj; Anderson, Troy D; Bloomquist, Jeffrey R; Carlier, Paul R; Wong, Dawn M; Lam, Polo C-H; Totrov, Maxim M

Re-engineering aryl methylcarbamates to confer high selectivity for inhibition of Anopheles gambiae versus human acetylcholinesterase.

对芳基甲基氨基甲酸酯进行重新设计,使其对冈比亚按蚊抑制作用具有高选择性,而对人类乙酰胆碱酯酶则无此作用

Hartsel Joshua A, Wong Dawn M, Mutunga James M, Ma Ming, Anderson Troy D, Wysinski Ania, Islam Rafique, Wong Eric A, Paulson Sally L, Li Jianyong, Lam Polo C H, Totrov Maxim M, Bloomquist Jeffrey R, Carlier Paul R