日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Large-scale RNA-Seq mining reveals ciclopirox olamine induces TDP-43 cryptic exons.

大规模 RNA-Seq 挖掘揭示环吡咯醇胺诱导 TDP-43 隐蔽外显子

Sinha Irika R, Sandal Parker S, Spence Holly, Burns Grace D, Mallika Aswathy Peethambaran, Abbasinejad Fatemeh, Irwin Katherine E, Cruz Anna Lourdes F, Wang Vania, Marx Shaelyn R, Rodríguez Josué Llamas, Langmead Ben, Gregory Jenna M, Wong Philip C, Ling Jonathan P

Broad brain biodistribution conferred by an AAV to restore TDP-43 function mitigates Frontotemporal Demenia-like deficits

通过腺相关病毒(AAV)实现广泛的脑生物分布,从而恢复TDP-43功能,减轻额颞叶痴呆样症状。

Cao, Tianyu; Thapa, Rashmi; Liu, Rongsong; Mallika, Aswathy Peethambaran; Baghel, Meghraj Singh; Wei, Yijun; Sinha, Irika R; Burns, Grace D; Wen, Xinrui; Pang, Bo; Ling, Jonathan P; Lin, Da-Ting; Li, Yun; Wong, Philip C

Symptomatic treatment by a BBB-permeable AAV engineered to restore TDP-43 function slows motor neuron disease and prevents paralysis

利用经基因工程改造、可穿透血脑屏障的腺相关病毒(AAV)进行对症治疗,能够恢复TDP-43功能,从而延缓运动神经元疾病的进展并预防瘫痪。

Peethambaran Mallika, Aswathy; Yu, Jessica G; Sitzman, Opal; Baghel, Meghraj Singh; Renganathan, Shruti; Sinha, Irika R; Melnikova, Tatiana; Ling, Jonathan P; Wong, Philip C

Inhibition of nonsense-mediated decay in TDP-43 deficient neurons reveals novel cryptic exons

抑制TDP-43缺陷神经元中的无义介导衰变可揭示新的隐蔽外显子

Sinha, Irika R; Ye, Yingzhi; Li, Yini; Sandal, Parker S; Wong, Philip C; Sun, Shuying; Ling, Jonathan P

Brain Iron as a Surrogate Biomarker of Pathological TDP-43 Identifies Brain Region-Specific Signatures in Ageing, Alzheimer's Disease and Amyotrophic Lateral Sclerosis.

脑铁作为病理性 TDP-43 的替代生物标志物,可识别衰老、阿尔茨海默病和肌萎缩侧索硬化症中脑区特异性特征。

Waldron Fergal M, Spence Holly, Taso Orjona Stella, Read Fiona L, Sinha Irika R, Irwin Katherine E, Wong Philip C, Ling Jonathan P, Gregory Jenna M

Author Correction: A fluid biomarker reveals loss of TDP-43 splicing repression in presymptomatic ALS-FTD

作者更正:一项体液生物标志物揭示了ALS-FTD前驱期患者TDP-43剪接抑制的丧失。

Irwin, Katherine E; Jasin, Pei; Braunstein, Kerstin E; Sinha, Irika R; Garret, Mark A; Bowden, Kyra D; Chang, Koping; Troncoso, Juan C; Moghekar, Abhay; Oh, Esther S; Raitcheva, Denitza; Bartlett, Dan; Miller, Timothy; Berry, James D; Traynor, Bryan J; Ling, Jonathan P; Wong, Philip C

Fluid biomarkers for amyotrophic lateral sclerosis: a review

肌萎缩侧索硬化症的体液生物标志物:综述

Irwin, Katherine E; Sheth, Udit; Wong, Philip C; Gendron, Tania F

Roadmap for C9ORF72 in Frontotemporal Dementia and Amyotrophic Lateral Sclerosis: Report on the C9ORF72 FTD/ALS Summit

C9ORF72 在额颞叶痴呆和肌萎缩侧索硬化症中的应用路线图:C9ORF72 FTD/ALS 峰会报告

Sattler, Rita; Traynor, Bryan J; Robertson, Janice; Van Den Bosch, Ludo; Barmada, Sami J; Svendsen, Clive N; Disney, Matthew D; Gendron, Tania F; Wong, Philip C; Turner, Martin R; Boxer, Adam; Babu, Suma; Benatar, Michael; Kurnellas, Michael; Rohrer, Jonathan D; Donnelly, Christopher J; Bustos, Lynette M; Van Keuren-Jensen, Kendall; Dacks, Penny A; Sabbagh, Marwan N

Donald Lowell Price, M.D. In memoriam

唐纳德·洛厄尔·普莱斯医学博士(纪念)

Asch, Ruth H; Fowles, Krista; Pietrzak, Robert H; Taylor, Jane R; Esterlis, Irina; Sisodia, Sangram; Wong, Philip C

Pathological Tau transmission initiated by binding lymphocyte-activation gene 3

病理性Tau蛋白传递由淋巴细胞活化基因3结合启动

Chen, Chan; Kumbhar, Ramhari; Wang, Hu; Yang, Xiuli; Gadhave, Kundlik; Rastegar, Cyrus; Kimura, Yasuyoshi; Behensky, Adam; Katakam, Sruthi; Jeong, Deok; Wang, Liang; Wang, Anthony; Chen, Rong; Zhang, Shu; Jin, Lingtao; Workman, Creg J; Vignali, Dario A A; Pletinkova, Olga; Nauen, David W; Wong, Philip C; Troncoso, Juan C; Ying, Mingyao; Dawson, Valina L; Dawson, Ted M; Mao, Xiaobo