日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Ligand-activated EGFR/MAPK signaling but not PI3K, are key resistance mechanisms to EGFR-therapy in colorectal cancer.

配体激活的 EGFR/MAPK 信号通路(而非 PI3K)是结直肠癌中 EGFR 疗法产生耐药性的关键机制

Qu Xueping, Hamidi Habib, Johnson Radia M, Sokol Ethan S, Lin Eva, Eng Cathy, Kim Tae Won, Bendell Johanna, Sivakumar Smruthy, Kaplan Benjamin, de Sousa E Melo Felipe, Mancini Andrew, Wongchenko Matthew, Shi Yi, Shames David, Yan Yibing, Ciardiello Fortunato, Bais Carlos

Clinical Context Shapes the Relationship between Genomic Alterations and Response to AR Inhibitors and Chemotherapy in Metastatic Prostate Cancer.

临床背景决定了转移性前列腺癌中基因组改变与 AR 抑制剂和化疗反应之间的关系

Shah Kalpit, Secrest Matthew H, Zhou Wei, Wang Shu, Canter Dan, Zhang Yuxiang, Jin Dexter, Sokol Ethan, Nowicka Malgorzata, Ang Houle Armande, Metcalfe Ciara, Gendreau Steven, Schröder Carsten, Wongchenko Matthew, Attard Gerhardt

Circulating Tumor DNA Assessment for Treatment Monitoring Adds Value to PSA in Metastatic Castration-Resistant Prostate Cancer

循环肿瘤DNA检测在转移性去势抵抗性前列腺癌治疗监测中比PSA检测更具价值

Sweeney, Christopher J; Petry, Russell; Xu, Chang; Childress, Merrida; He, Jie; Fabrizio, David; Gjoerup, Ole; Morley, Samantha; Catlett, Timothy; Assaf, Zoe J; Yuen, Kobe; Wongchenko, Matthew; Shah, Kalpit; Gupta, Pratyush; Hegde, Priti; Pasquina, Lincoln W; Mariathasan, Sanjeev; Graf, Ryon P; Powles, Thomas

Ipatasertib plus Paclitaxel for Patients with PIK3CA/AKT1/PTEN-Altered Locally Advanced Unresectable or Metastatic Triple-Negative Breast Cancer in the IPATunity130 Phase III Trial

IPATunity130 III期试验中,Ipatasertib联合紫杉醇治疗PIK3CA/AKT1/PTEN改变的局部晚期不可切除或转移性三阴性乳腺癌患者

Dent, Rebecca A; Kim, Sung-Bae; Oliveira, Mafalda; Barrios, Carlos; O'Shaughnessy, Joyce; Isakoff, Steven J; Saji, Shigehira; Freitas-Junior, Ruffo; Philco, Manuel; Bondarenko, Igor; Lian, Qinshu; Bradley, Denise; Hinton, Heather; Wongchenko, Matthew J; Reilly, Sarah-Jayne; Turner, Nicholas

Tumor-intrinsic expression of the autophagy gene Atg16l1 suppresses anti-tumor immunity in colorectal cancer

肿瘤细胞内自噬基因Atg16l1的表达抑制结直肠癌的抗肿瘤免疫

Lucia Taraborrelli # ,Yasin Şenbabaoğlu # ,Lifen Wang # ,Junghyun Lim ,Kerrigan Blake ,Noelyn Kljavin ,Sarah Gierke ,Alexis Scherl ,James Ziai ,Erin McNamara ,Mark Owyong ,Shilpa Rao ,Aslihan Karabacak Calviello ,Daniel Oreper ,Suchit Jhunjhunwala ,Guillem Argiles ,Johanna Bendell ,Tae Won Kim ,Fortunato Ciardiello ,Matthew J Wongchenko ,Frederic J de Sauvage ,Felipe de Sousa E Melo ,Yibing Yan ,Nathaniel R West ,Aditya Murthy

Author Correction: Tumour gene expression signature in primary melanoma predicts long-term outcomes

作者更正:原发性黑色素瘤的肿瘤基因表达特征可预测长期预后

Garg, Manik; Couturier, Dominique-Laurent; Nsengimana, Jérémie; Fonseca, Nuno A; Wongchenko, Matthew; Yan, Yibing; Lauss, Martin; Jönsson, Göran B; Newton-Bishop, Julia; Parkinson, Christine; Middleton, Mark R; Bishop, D Timothy; McDonald, Sarah; Stefanos, Nikki; Tadross, John; Vergara, Ismael A; Lo, Serigne; Newell, Felicity; Wilmott, James S; Thompson, John F; Long, Georgina V; Scolyer, Richard A; Corrie, Pippa; Adams, David J; Brazma, Alvis; Rabbie, Roy

Functional Mapping of AKT Signaling and Biomarkers of Response from the FAIRLANE Trial of Neoadjuvant Ipatasertib plus Paclitaxel for Triple-Negative Breast Cancer

FAIRLANE试验中新辅助伊帕他替尼联合紫杉醇治疗三阴性乳腺癌的AKT信号通路功能图谱及疗效生物标志物

Shi, Zhen; Wulfkuhle, Julia; Nowicka, Malgorzata; Gallagher, Rosa I; Saura, Cristina; Nuciforo, Paolo G; Calvo, Isabel; Andersen, Jay; Passos-Coelho, José Luis; Gil-Gil, Miguel J; Bermejo, Begoña; Pratt, Debra A; Ciruelos, Eva M; Villagrasa, Patricia; Wongchenko, Matthew J; Petricoin, Emanuel F; Oliveira, Mafalda; Isakoff, Steven J

Ipatasertib plus paclitaxel for PIK3CA/AKT1/PTEN-altered hormone receptor-positive HER2-negative advanced breast cancer: primary results from cohort B of the IPATunity130 randomized phase 3 trial

伊帕他替尼联合紫杉醇治疗PIK3CA/AKT1/PTEN改变的激素受体阳性HER2阴性晚期乳腺癌:IPATunity130随机3期试验B组的主要结果

Turner, Nicholas; Dent, Rebecca A; O'Shaughnessy, Joyce; Kim, Sung-Bae; Isakoff, Steven J; Barrios, Carlos; Saji, Shigehira; Bondarenko, Igor; Nowecki, Zbigniew; Lian, Qinshu; Reilly, Sarah-Jayne; Hinton, Heather; Wongchenko, Matthew J; Kovic, Bruno; Mani, Aruna; Oliveira, Mafalda

Tumour gene expression signature in primary melanoma predicts long-term outcomes

原发性黑色素瘤的肿瘤基因表达特征可预测长期预后

Garg, Manik; Couturier, Dominique-Laurent; Nsengimana, Jérémie; Fonseca, Nuno A; Wongchenko, Matthew; Yan, Yibing; Lauss, Martin; Jönsson, Göran B; Newton-Bishop, Julia; Parkinson, Christine; Middleton, Mark R; Bishop, D Timothy; McDonald, Sarah; Stefanos, Nikki; Tadross, John; Vergara, Ismael A; Lo, Serigne; Newell, Felicity; Wilmott, James S; Thompson, John F; Long, Georgina V; Scolyer, Richard A; Corrie, Pippa; Adams, David J; Brazma, Alvis; Rabbie, Roy

Extended 5-Year Follow-up Results of a Phase Ib Study (BRIM7) of Vemurafenib and Cobimetinib in BRAF-Mutant Melanoma

一项针对BRAF突变型黑色素瘤的Vemurafenib和Cobimetinib Ib期研究(BRIM7)的5年延长随访结果

Ribas, Antoni; Daud, Adil; Pavlick, Anna C; Gonzalez, Rene; Lewis, Karl D; Hamid, Omid; Gajewski, Thomas F; Puzanov, Igor; Wongchenko, Matthew; Rooney, Isabelle; Hsu, Jessie J; Yan, Yibing; Park, Erica; McArthur, Grant A