日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of VU0467319: an M(1) Positive Allosteric Modulator Candidate That Advanced into Clinical Trials

VU0467319 的发现:一种进入临床试验的 M(1) 正向变构调节剂候选药物

Poslunsey, Michael S; Wood, Michael R; Han, Changho; Stauffer, Shaun R; Panarese, Joseph D; Melancon, Bruce J; Engers, Julie L; Dickerson, Jonathan W; Peng, Weimin; Noetzel, Meredith J; Cho, Hyekyung P; Rodriguez, Alice L; Hopkins, Corey R; Morrison, Ryan; Crouch, Rachel D; Bridges, Thomas M; Blobaum, Anna L; Boutaud, Olivier; Daniels, J Scott; Kates, Michael J; Castelhano, Arlindo; Rook, Jerri M; Niswender, Colleen M; Jones, Carrie K; Conn, P Jeffrey; Lindsley, Craig W

Clinical recommendations for polygenic risk score-enhanced breast cancer screening: Can.Heal project

基于多基因风险评分的乳腺癌筛查临床建议:Can.Heal 项目

Bubser, Michael; Bridges, Thomas M; Dencker, Ditte; Gould, Robert W; Grannan, Michael; Noetzel, Meredith J; Lamsal, Atin; Niswender, Colleen M; Daniels, J Scott; Poslusney, Michael S; Melancon, Bruce J; Tarr, James C; Byers, Frank W; Wess, Jürgen; Duggan, Mark E; Dunlop, John; Wood, Michael W; Brandon, Nicholas J; Wood, Michael R; Lindsley, Craig W; Conn, P Jeffrey; Jones, Carrie K; Taha, A; Matt McCrary, J; van Rooij, J; Lahousse, L; Paoletti, F; Pascucci, E; Vaht, M; Pastorino, R; Pezzullo, A M; Boccia, S

Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation

轻度呼吸道新冠肺炎可导致多系神经细胞和髓鞘功能紊乱

Anthony Fernández-Castañeda ,Peiwen Lu ,Anna C Geraghty ,Eric Song ,Myoung-Hwa Lee ,Jamie Wood ,Michael R O'Dea ,Selena Dutton ,Kiarash Shamardani ,Kamsi Nwangwu ,Rebecca Mancusi ,Belgin Yalçın ,Kathryn R Taylor ,Lehi Acosta-Alvarez ,Karen Malacon ,Michael B Keough ,Lijun Ni ,Pamelyn J Woo ,Daniel Contreras-Esquivel ,Angus Martin Shaw Toland ,Jeff R Gehlhausen ,Jon Klein ,Takehiro Takahashi ,Julio Silva ,Benjamin Israelow ,Carolina Lucas ,Tianyang Mao ,Mario A Peña-Hernández ,Alexandra Tabachnikova ,Robert J Homer ,Laura Tabacof ,Jenna Tosto-Mancuso ,Erica Breyman ,Amy Kontorovich ,Dayna McCarthy ,Martha Quezado ,Hannes Vogel ,Marco M Hefti ,Daniel P Perl ,Shane Liddelow ,Rebecca Folkerth ,David Putrino ,Avindra Nath ,Akiko Iwasaki ,Michelle Monje

Pericarditis and Autoinflammation: A Clinical and Genetic Analysis of Patients With Idiopathic Recurrent Pericarditis and Monogenic Autoinflammatory Diseases at a National Referral Center

心包炎与自身炎症:国家转诊中心特发性复发性心包炎和单基因自身炎症性疾病患者的临床和遗传分析

Peet, Claire J; Rowczenio, Dorota; Omoyinmi, Ebun; Papadopoulou, Charalampia; Mapalo, Bella Ruth R; Wood, Michael R; Capon, Francesca; Lachmann, Helen J

COVID-19 and autoinflammatory diseases: prevalence and outcomes of infection and early experience of vaccination in patients on biologics

COVID-19 与自身炎症性疾病:感染的流行情况和结果以及生物制剂治疗患者的早期疫苗接种经验

Peet, Claire J; Papadopoulou, Charalampia; Sombrito, Bella Ruth M; Wood, Michael R; Lachmann, Helen J

Physiology of Highly Radioresistant Escherichia coli After Experimental Evolution for 100 Cycles of Selection

经过 100 轮选择实验进化后高辐射抗性大肠杆菌的生理学

Steven T Bruckbauer, Joel Martin, Benjamin B Minkoff, Mike T Veling, Illissa Lancaster, Jessica Liu, Joseph D Trimarco, Brian Bushnell, Anna Lipzen, Elizabeth A Wood, Michael R Sussman, Christa Pennacchio, Michael M Cox

Novel M(4) positive allosteric modulators derived from questioning the role and impact of a presumed intramolecular hydrogen-bonding motif in β-amino carboxamide-harboring ligands

通过质疑β-氨基羧酰胺配体中假定的分子内氢键基序的作用和影响,开发出新型M(4)正变构调节剂

Poslusney, Michael S; Salovich, James M; Wood, Michael R; Melancon, Bruce J; Bollinger, Katrina A; Luscombe, Vincent B; Rodriguez, Alice L; Engers, Darren W; Bridges, Thomas M; Niswender, Colleen M; Conn, P Jeffrey; Lindsley, Craig W

SAR inspired by aldehyde oxidase (AO) metabolism: Discovery of novel, CNS penetrant tricyclic M(4) PAMs

受醛氧化酶 (AO) 代谢启发的 SAR 研究:新型中枢神经系统穿透性三环 M(4) PAM 的发现

Chopko, Trevor C; Han, Changho; Gregro, Alison R; Engers, Darren W; Felts, Andrew S; Poslusney, Mike S; Bollinger, Katrina A; Morrison, Ryan D; Bubser, Michael; Lamsal, Atin; Luscombe, Vincent B; Cho, Hyekyung P; Schnetz-Boutaud, Nathalie C; Rodriguez, Alice L; Chang, Sichen; Daniels, J Scott; Stec, Donald F; Niswender, Colleen M; Jones, Carrie K; Wood, Michael R; Wood, Michael W; Duggan, Mark E; Brandon, Nicholas J; Conn, P Jeffrey; Bridges, Thomas M; Lindsley, Craig W; Melancon, Bruce J

Corrigendum to "Challenges in the development of an M(4) PAM preclinical candidate: The discovery, SAR, and biological characterization of a series of azetidine-derived tertiary amides" [Bioorg. Med. Chem. Lett. 27(23) (2017) 5179-5184]

对“M(4) PAM 临床前候选药物开发中的挑战:一系列氮杂环丁烷衍生的叔酰胺的发现、构效关系和生物学表征”的更正 [Bioorg. Med. Chem. Lett. 27(23) (2017) 5179-5184]

Tarr, James C; Wood, Michael R; Noetzel, Meredith J; Melancon, Bruce J; Lamsal, Atin; Luscombe, Vincent B; Rodriguez, Alice L; Byers, Frank W; Chang, Sichen; Cho, Hyekyung P; Engers, Darren W; Jones, Carrie K; Niswender, Colleen M; Wood, Michael W; Brandon, Nicholas J; Duggan, Mark E; Jeffrey Conn, P; Bridges, Thomas M; Lindsley, Craig W

Challenges in the development of an M(4) PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogs

M(4) PAM 体内工具化合物开发面临的挑战:VU0467154 的发现及其近缘类似物出乎意料的 DMPK 特征

Wood, Michael R; Noetzel, Meredith J; Poslusney, Michael S; Melancon, Bruce J; Tarr, James C; Lamsal, Atin; Chang, Sichen; Luscombe, Vincent B; Weiner, Rebecca L; Cho, Hyekyung P; Bubser, Michael; Jones, Carrie K; Niswender, Colleen M; Wood, Michael W; Engers, Darren W; Brandon, Nicholas J; Duggan, Mark E; Conn, P Jeffrey; Bridges, Thomas M; Lindsley, Craig W