日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A tubulin alpha 8 mouse knockout model indicates a likely role in spermatogenesis but not in brain development

α8微管蛋白敲除小鼠模型表明,该基因可能在精子发生中发挥作用,但在大脑发育中则不然。

Diggle, Christine P; Martinez-Garay, Isabel; Molnar, Zoltan; Brinkworth, Martin H; White, Ed; Fowler, Ewan; Hughes, Ruth; Hayward, Bruce E; Carr, Ian M; Watson, Christopher M; Crinnion, Laura; Asipu, Aruna; Woodman, Ben; Coletta, P Louise; Markham, Alexander F; Dear, T Neil; Bonthron, David T; Peckham, Michelle; Morrison, Ewan E; Sheridan, Eamonn

SAHA decreases HDAC 2 and 4 levels in vivo and improves molecular phenotypes in the R6/2 mouse model of Huntington's disease.

SAHA 可降低体内 HDAC 2 和 4 的水平,并改善亨廷顿病 R6/2 小鼠模型的分子表型

Mielcarek Michal, Benn Caroline L, Franklin Sophie A, Smith Donna L, Woodman Ben, Marks Paul A, Bates Gillian P

CalDAG-GEFI down-regulation in the striatum as a neuroprotective change in Huntington's disease

亨廷顿病中纹状体CalDAG-GEFI下调是一种神经保护性改变

Crittenden, Jill R; Dunn, Denise E; Merali, Farhan I; Woodman, Ben; Yim, Michael; Borkowska, Anna E; Frosch, Matthew P; Bates, Gillian P; Housman, David E; Lo, Donald C; Graybiel, Ann M

Formation of polyglutamine inclusions in a wide range of non-CNS tissues in the HdhQ150 knock-in mouse model of Huntington's disease.

在亨廷顿病 HdhQ150 敲入小鼠模型中,多种非中枢神经系统组织中均形成了多聚谷氨酰胺包涵体

Moffitt Hilary, McPhail Graham D, Woodman Ben, Hobbs Carl, Bates Gillian P

Genetic knock-down of HDAC7 does not ameliorate disease pathogenesis in the R6/2 mouse model of Huntington's disease.

在亨廷顿病的 R6/2 小鼠模型中,基因敲除 HDAC7 并不能改善疾病的发病机制

Benn Caroline L, Butler Rachel, Mariner Lydia, Nixon Jude, Moffitt Hilary, Mielcarek Michal, Woodman Ben, Bates Gillian P