日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Conformational Dynamics of Amylin Receptors Revealed by Hydrogen-Deuterium Exchange Mass Spectrometry

利用氢氘交换质谱法揭示胰淀素受体的构象动力学

Fairweather, Cameron J; Zhang, Xin; Fernando, C Dilanka; Garama, Daniel J; Sexton, Patrick M; Wootten, Denise; Josephs, Tracy M

Structural and dynamic features of cagrilintide binding to calcitonin and amylin receptors.

卡格里林肽与降钙素和胰淀素受体结合的结构和动力学特征

Cao Jianjun, Belousoff Matthew J, Johnson Rachel M, Keov Peter, Mariam Zamara, Deganutti Giuseppe, Christopoulos George, Hick Caroline A, Reedtz-Runge Steffen, Glendorf Tine, Ballarín-González Borja, Raun Kirsten, Bayly-Jones Charles, Wootten Denise, Sexton Patrick M

Structural basis of modified ligand selectivity from N-terminal PAC1R alternative splicing

PAC1R N端选择性剪接修饰配体选择性的结构基础

Lu, Jessica J; Deganutti, Giuseppe; Li, Miaomiao; Humphrys, Laura J; Li, Yandi; Nettleton, Theodore J; Venugopal, Hariprasad; Julita, Villy; Christopoulos, George; Reynolds, Christopher A; Sexton, Patrick M; Wootten, Denise; Zhao, Peishen; Piper, Sarah J

Prolonged signaling of backbone-modified glucagon-like peptide-1 analogues with diverse receptor trafficking

骨架修饰的胰高血糖素样肽-1类似物通过多种受体转运实现延长信号传导

Cary, Brian P; Hager, Marlies V; Mariam, Zamara; Morris, Rylie K; Belousoff, Matthew J; Deganutti, Giuseppe; Sexton, Patrick M; Wootten, Denise; Gellman, Samuel H

Glucose-dependent insulinotropic polypeptide (GIP)

葡萄糖依赖性促胰岛素多肽(GIP)

Müller, Timo D; Adriaenssens, Alice; Ahrén, Bo; Blüher, Matthias; Birkenfeld, Andreas L; Campbell, Jonathan E; Coghlan, Matthew P; D'Alessio, David; Deacon, Carolyn F; DelPrato, Stefano; Douros, Jonathan D; Drucker, Daniel J; Figueredo Burgos, Natalie S; Flatt, Peter R; Finan, Brian; Gimeno, Ruth E; Gribble, Fiona M; Hayes, Matthew R; Hölscher, Christian; Holst, Jens J; Knerr, Patrick J; Knop, Filip K; Kusminski, Christine M; Liskiewicz, Arkadiusz; Mabilleau, Guillaume; Mowery, Stephanie A; Nauck, Michael A; Novikoff, Aaron; Reimann, Frank; Roberts, Anna G; Rosenkilde, Mette M; Samms, Ricardo J; Scherer, Philip E; Seeley, Randy J; Sloop, Kyle W; Wolfrum, Christian; Wootten, Denise; DiMarchi, Richard D; Tschöp, Matthias H

In vivo functional profiling and structural characterisation of the human Glp1r A316T variant

人Glp1r A316T变体的体内功能分析和结构表征

El Eid, Liliane; Deane-Alder, Kieran; Rujan, Roxana-Maria; Mariam, Zamara; Oqua, Affiong I; Manchanda, Yusman; Belousoff, Matthew J; Bernardino de la Serna, Jorge; Sloop, Kyle W; Rutter, Guy A; Montoya, Alex; Withers, Dominic J; Millership, Steven; Bouzakri, Karim; Jones, Ben; Reynolds, Christopher A; Sexton, Patrick M; Wootten, Denise; Deganutti, Giuseppe; Tomas, Alejandra

De novo design of miniprotein agonists and antagonists targeting G protein-coupled receptors.

从头设计靶向 G 蛋白偶联受体的微型蛋白激动剂和拮抗剂

Muratspahić Edin, Feldman David, Kim David E, Qu Xiangli, Bratovianu Ana-Maria, Rivera-Sánchez Paula, Dimitri Federica, Cao Jason, Cary Brian P, Belousoff Matthew J, Keov Peter, Chen Qingchao, Ren Yue, Fine Justyn, Sappington Isaac, Schlichthaerle Thomas, Zhang Jason Z, Pillai Arvind, Mihaljević Ljubica, Bauer Magnus, Torres Susana Vázquez, Motmaen Amir, Lee Gyu Rie, Tran Long, Wang Xinru, Goreshnik Inna, Vafeados Dionne K, Svendsen Justin E, Hosseinzadeh Parisa, Lindegaard Nicolai, Brandt Matthäus, Waltenspühl Yann, Deibler Kristine, Oostdyk Luke, Cao William, Anantharaman Lakshmi, Stewart Lance, Halloran Lauren, Spangler Jamie B, Sexton Patrick M, Roth Bryan L, Krumm Brian E, Wootten Denise, Tate Christopher G, Norn Christoffer, Baker David

Impact of secretin receptor homo-dimerization on natural ligand binding

促胰液素受体同源二聚化对天然配体结合的影响

Harikumar, Kaleeckal G; Piper, Sarah J; Christopoulos, Arthur; Wootten, Denise; Sexton, Patrick M; Miller, Laurence J

Lipid-Dependent Activation of the Orphan G Protein-Coupled Receptor, GPR3

孤儿G蛋白偶联受体GPR3的脂质依赖性激活

Russell, Isabella C; Zhang, Xin; Bumbak, Fabian; McNeill, Samantha M; Josephs, Tracy M; Leeming, Michael G; Christopoulos, George; Venugopal, Hariprasad; Flocco, Maria M; Sexton, Patrick M; Wootten, Denise; Belousoff, Matthew J

Cryo-EM Structure of the Human Amylin 1 Receptor in Complex with CGRP and Gs Protein

人胰淀素1受体与CGRP和Gs蛋白复合物的冷冻电镜结构

Cao, Jianjun; Belousoff, Matthew J; Danev, Radostin; Christopoulos, Arthur; Wootten, Denise; Sexton, Patrick M