日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Short salsalate administration affects cell proliferation, metabolism, and inflammation in polycystic kidney disease

短期服用水杨酸会影响多囊肾病中的细胞增殖、代谢和炎症

Anish A Kanhai, Elena Sánchez-López, Thomas B Kuipers, Jan B van Klinken, Kyra L Dijkstra, Inge van der Veen, Hans J Baelde, Xuewen Song, York Pei, Hailiang Mei, Wouter N Leonhard, Oleg A Mayboroda, Dorien J M Peters

Preclinical evaluation of tolvaptan and salsalate combination therapy in a Pkd1-mouse model

托伐普坦与水杨酸联合治疗在 Pkd1 小鼠模型中的临床前评估

Xuewen Song, Wouter N Leonhard, Anish A Kanhai, Gregory R Steinberg, York Pei, Dorien J M Peters

Effects of Hydrochlorothiazide and Metformin on Aquaresis and Nephroprotection by a Vasopressin V2 Receptor Antagonist in ADPKD: A Randomized Crossover Trial

氢氯噻嗪和二甲双胍对 ADPKD 患者通过血管加压素 V2 受体拮抗剂进行利尿和肾脏保护作用的影响:一项随机交叉试验

Kramers, Bart J; Koorevaar, Iris W; van Gastel, Maatje D A; van Goor, Harry; Hallows, Kenneth R; Heerspink, Hiddo L; Li, Hui; Leonhard, Wouter N; Peters, Dorien J M; Qiu, Jiedong; Touw, Daan J; Gansevoort, Ron T; Meijer, Esther

Next-generation biological control: the need for integrating genetics and genomics

下一代生物防治:整合遗传学和基因组学的必要性

Leung, Kelley; Ras, Erica; Ferguson, Kim B; Ariëns, Simone; Babendreier, Dirk; Bijma, Piter; Bourtzis, Kostas; Brodeur, Jacques; Bruins, Margreet A; Centurión, Alejandra; Chattington, Sophie R; Chinchilla-Ramírez, Milena; Dicke, Marcel; Fatouros, Nina E; González-Cabrera, Joel; Groot, Thomas V M; Haye, Tim; Knapp, Markus; Koskinioti, Panagiota; Le Hesran, Sophie; Lyrakis, Manolis; Paspati, Angeliki; Pérez-Hedo, Meritxell; Plouvier, Wouter N; Schlötterer, Christian; Stahl, Judith M; Thiel, Andra; Urbaneja, Alberto; van de Zande, Louis; Verhulst, Eveline C; Vet, Louise E M; Visser, Sander; Werren, John H; Xia, Shuwen; Zwaan, Bas J; Magalhães, Sara; Beukeboom, Leo W; Pannebakker, Bart A

Prioritization of novel ADPKD drug candidates from disease-stage specific gene expression profiles.

根据疾病阶段特异性基因表达谱对新型 ADPKD 候选药物进行优先排序

Malas Tareq B, Leonhard Wouter N, Bange Hester, Granchi Zoraide, Hettne Kristina M, Van Westen Gerard J P, Price Leo S, 't Hoen Peter A C, Peters Dorien J M

In vitro 3D phenotypic drug screen identifies celastrol as an effective in vivo inhibitor of polycystic kidney disease

体外 3D 表型药物筛选证实雷公藤红素是有效的体内多囊肾病抑制剂

Tijmen H Booij, Wouter N Leonhard, Hester Bange, Kuan Yan, Michiel Fokkelman, Anna J Plugge, Kimberley A M Veraar, Johannes G Dauwerse, Gerard J P van Westen, Bob van de Water, Leo S Price, Dorien J M Peters

Renal cyst growth is attenuated by a combination treatment of tolvaptan and pioglitazone, while pioglitazone treatment alone is not effective

托伐普坦和吡格列酮联合治疗可减缓肾囊肿生长,而单独使用吡格列酮治疗无效

Anish A Kanhai, Hester Bange, Lotte Verburg, Kyra L Dijkstra, Leo S Price, Dorien J M Peters, Wouter N Leonhard

Salsalate, but not metformin or canagliflozin, slows kidney cyst growth in an adult-onset mouse model of polycystic kidney disease

沙水杨酸酯(而非二甲双胍或卡格列净)可减缓成年多囊肾病小鼠模型中的肾囊肿生长

Wouter N Leonhard, Xuewen Song, Anish A Kanhai, Ioan-Andrei Iliuta, Andrea Bozovic, Gregory R Steinberg, Dorien J M Peters, York Pei

Fluid shear stress-induced TGF-β/ALK5 signaling in renal epithelial cells is modulated by MEK1/2

肾脏上皮细胞中流体剪切应力诱导的 TGF-β/ALK5 信号传导受 MEK1/2 调节

Steven J Kunnen, Wouter N Leonhard, Cor Semeins, Lukas J A C Hawinkels, Christian Poelma, Peter Ten Dijke, Astrid Bakker, Beerend P Hierck, Dorien J M Peters

High-Throughput Phenotypic Screening of Kinase Inhibitors to Identify Drug Targets for Polycystic Kidney Disease

通过高通量表型筛选激酶抑制剂来确定多囊肾病的药物靶点

Tijmen H Booij, Hester Bange, Wouter N Leonhard, Kuan Yan, Michiel Fokkelman, Steven J Kunnen, Johannes G Dauwerse, Yu Qin, Bob van de Water, Gerard J P van Westen, Dorien J M Peters, Leo S Price