AG-348 (Mitapivat), an allosteric activator of red blood cell pyruvate kinase, increases enzymatic activity, protein stability, and ATP levels over a broad range of PKLR genotypes
AG-348 (Mitapivat) 是一种红细胞丙酮酸激酶的变构激活剂,可提高多种 PKLR 基因型的酶活性、蛋白质稳定性和 ATP 水平
期刊:Haematologica
影响因子:8.2
doi:10.3324/haematol.2019.238865
Minke A E Rab, Brigitte A Van Oirschot, Penelope A Kosinski, Jeffrey Hixon, Kendall Johnson, Victor Chubukov, Lenny Dang, Gerard Pasterkamp, Stephanie Van Straaten, Wouter W Van Solinge, Eduard J Van Beers, Charles Kung, Richard Van Wijk