日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

A trial design to maximize knowledge of the effects of rodatristat ethyl in the treatment of pulmonary arterial hypertension (ELEVATE 2)

一项旨在最大限度了解罗达曲司他乙酯治疗肺动脉高压效果的试验设计（ELEVATE 2）

期刊:Pulmonary Circulation
影响因子:2.5
doi:10.1002/pul2.12088
Lazarus, Howard M; Denning, Jill; Wring, Stephen; Palacios, Michelle; Hoffman, Sidra; Crizer, Katelyn; Kamau-Kelley, Watiri; Symonds, William; Feldman, Jeremy
肺动脉高压
心血管
发表日期：2022
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SCY-078, a Novel Fungicidal Agent, Demonstrates Distribution to Tissues Associated with Fungal Infections during Mass Balance Studies with Intravenous and Oral [(14)C]SCY-078 in Albino and Pigmented Rats

新型杀真菌剂 SCY-078 在白化大鼠和有色大鼠中通过静脉注射和口服 [(14)C]SCY-078 进行质量平衡研究，结果表明其分布于与真菌感染相关的组织中。

期刊:Antimicrobial Agents and Chemotherapy
影响因子:4.5
doi:10.1128/AAC.02119-18
Wring, Stephen; Borroto-Esoda, Katyna; Solon, Eric; Angulo, David
炎症/感染
Rat
微生物学
发表日期：2019
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A Novel 1,3-Beta-d-Glucan Inhibitor, Ibrexafungerp (Formerly SCY-078), Shows Potent Activity in the Lower pH Environment of Vulvovaginitis

一种新型 1,3-β-D-葡聚糖抑制剂 Ibrexafungerp（原名 SCY-078）在阴道炎的低 pH 环境中显示出强效活性

期刊:Antimicrobial Agents and Chemotherapy
影响因子:4.5
doi:10.1128/AAC.02611-18
Larkin, E L; Long, L; Isham, N; Borroto-Esoda, K; Barat, S; Angulo, D; Wring, S; Ghannoum, M
发表日期：2019
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Topical Treatment for Cutaneous Leishmaniasis: Dermato-Pharmacokinetic Lead Optimization of Benzoxaboroles

皮肤利什曼病局部治疗：苯并硼氧烷类化合物的皮肤药代动力学先导化合物优化

期刊:Antimicrobial Agents and Chemotherapy
影响因子:4.5
doi:10.1128/AAC.02419-17
Van Bocxlaer, Katrien; Gaukel, Eric; Hauser, Deirdre; Park, Seong Hee; Schock, Sara; Yardley, Vanessa; Randolph, Ryan; Plattner, Jacob J; Merchant, Tejal; Croft, Simon L; Jacobs, Robert T; Wring, Stephen A
发表日期：2018
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Lack of Impact by SCY-078, a First-in-Class Oral Fungicidal Glucan Synthase Inhibitor, on the Pharmacokinetics of Rosiglitazone, a Substrate for CYP450 2C8, Supports the Low Risk for Clinically Relevant Metabolic Drug-Drug Interactions

SCY-078（一种首创的口服抗真菌葡聚糖合成酶抑制剂）对 CYP450 2C8 底物罗格列酮的药代动力学无影响，这表明其发生具有临床意义的代谢性药物相互作用的风险较低。

期刊:Journal of Clinical Pharmacology
影响因子:2.3
doi:10.1002/jcph.1146
Wring, Stephen; Murphy, Gail; Atiee, George; Corr, Christy; Hyman, Michele; Willett, Michael; Angulo, David
微生物学
代谢
发表日期：2018
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Assessment of a pretomanid analogue library for African trypanosomiasis: Hit-to-lead studies on 6-substituted 2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine 8-oxides

对普雷托马尼类似物库进行评估，用于治疗非洲锥虫病：6-取代的2-硝基-6,7-二氢-5H-咪唑并[2,1-b][1,3]噻嗪8-氧化物的先导化合物研究

期刊:Bioorganic & Medicinal Chemistry Letters
影响因子:2.2
doi:10.1016/j.bmcl.2017.10.067
Thompson, Andrew M; Marshall, Andrew J; Maes, Louis; Yarlett, Nigel; Bacchi, Cyrus J; Gaukel, Eric; Wring, Stephen A; Launay, Delphine; Braillard, Stephanie; Chatelain, Eric; Mowbray, Charles E; Denny, William A
发表日期：2018
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Simulating Intestinal Transporter and Enzyme Activity in a Physiologically Based Pharmacokinetic Model for Tenofovir Disoproxil Fumarate

在基于生理的药代动力学模型中模拟富马酸替诺福韦二吡呋酯的肠道转运体和酶活性

期刊:Antimicrobial Agents and Chemotherapy
影响因子:4.5
doi:10.1128/AAC.00105-17
Moss, Darren M; Domanico, Paul; Watkins, Melynda; Park, Seonghee; Randolph, Ryan; Wring, Steve; Rajoli, Rajith Kumar Reddy; Hobson, James; Rannard, Steve; Siccardi, Marco; Owen, Andrew
发表日期：2017
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Preclinical Pharmacokinetics and Pharmacodynamic Target of SCY-078, a First-in-Class Orally Active Antifungal Glucan Synthesis Inhibitor, in Murine Models of Disseminated Candidiasis

SCY-078（一种首创的口服活性抗真菌葡聚糖合成抑制剂）在播散性念珠菌病小鼠模型中的临床前药代动力学和药效学靶点研究

期刊:Antimicrobial Agents and Chemotherapy
影响因子:4.5
doi:10.1128/AAC.02068-16
Wring, Stephen A; Randolph, Ryan; Park, SeongHee; Abruzzo, George; Chen, Qing; Flattery, Amy; Garrett, Graig; Peel, Michael; Outcalt, Russell; Powell, Kendall; Trucksis, Michelle; Angulo, David; Borroto-Esoda, Katyna
微生物学
发表日期：2017
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SCY-078 Is Fungicidal against Candida Species in Time-Kill Studies

SCY-078 在时间杀灭研究中对念珠菌属具有杀菌作用

期刊:Antimicrobial Agents and Chemotherapy
影响因子:4.1
doi:10.1128/AAC.01961-16
Bernard Scorneaux, David Angulo, Katyna Borroto-Esoda, Mahmoud Ghannoum, Michael Peel, Stephen Wring
微生物学
发表日期：2017
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The Emerging Pathogen Candida auris: Growth Phenotype, Virulence Factors, Activity of Antifungals, and Effect of SCY-078, a Novel Glucan Synthesis Inhibitor, on Growth Morphology and Biofilm Formation

新兴病原菌耳念珠菌：生长表型、毒力因子、抗真菌活性以及新型葡聚糖合成抑制剂 SCY-078 对生长形态和生物膜形成的影响

期刊:Antimicrobial Agents and Chemotherapy
影响因子:4.1
doi:10.1128/AAC.02396-16
Emily Larkin, Christopher Hager, Jyotsna Chandra, Pranab K Mukherjee, Mauricio Retuerto, Iman Salem, Lisa Long, Nancy Isham, Laura Kovanda, Katyna Borroto-Esoda, Steve Wring, David Angulo, Mahmoud Ghannoum
信号转导
发表日期：2017
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