日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

NAD(P)(+)-dependent alcohol oxidoreductases oxidize 7-hydroxycannabidiol to a reactive formyl metabolite

NAD(P)(+)依赖性醇氧化还原酶将7-羟基大麻二酚氧化成活性甲酰代谢物。

期刊:Archives of Toxicology
影响因子:6.9
doi:10.1007/s00204-025-04140-x
Wu, Qiangen; Fang, Jia-Long; Nagumalli, Suresh K; Guo, Xiaoqing; Beland, Frederick A
代谢
发表日期：2025
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7-Hydroxycannabidiol and 7-carboxycannabidiol induced cytotoxicity via apoptosis and endoplasmic reticulum stress in human hepatic cells.

7-羟基大麻二酚和7-羧基大麻二酚通过诱导人肝细胞凋亡和内质网应激而产生细胞毒性

期刊:Archives of Toxicology
影响因子:6.9
doi:10.1007/s00204-025-04001-7
Li Yuxi, Li Xilin, Wu Qiangen, Puig Montserrat, Moulin Frederic, Choudhuri Supratim, Gingrich Jeremy, Guo Lei, Chen Si
细胞生物学
Apoptosis
Human
凋亡
发表日期：2025
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Metabolism and liver toxicity of cannabidiol

大麻二酚的代谢和肝毒性

期刊:Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis
影响因子:2.3
doi:10.1080/26896583.2024.2366741
Chen, Si; Li, Yuxi; Li, Xilin; Wu, Qiangen; Puig, Montserrat; Moulin, Frederic; Gingrich, Jeremy; Guo, Lei
毒理研究
代谢
发表日期：2024
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Integration of transcriptome analysis with pathophysiological endpoints to evaluate cigarette smoke toxicity in an in vitro human airway tissue model

结合转录组分析与病理生理终点来评估体外人体气道组织模型中的香烟烟雾毒性

期刊:Archives of Toxicology
影响因子:4.8
doi:10.1007/s00204-021-03008-0
Rui Xiong, Yue Wu, Qiangen Wu, Levan Muskhelishvili, Kelly Davis, Priya Tripathi, Ying Chen, Tao Chen, Matthew Bryant, Hans Rosenfeldt, Sheila M Healy, Xuefei Cao
信号转导
Human
发表日期：2021
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Characterization of cytochrome P450s (CYP)-overexpressing HepG2 cells for assessing drug and chemical-induced liver toxicity

对过表达细胞色素P450（CYP）的HepG2细胞进行表征，以评估药物和化学物质引起的肝毒性

期刊:Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis
影响因子:2.3
doi:10.1080/26896583.2021.1880242
Chen, Si; Wu, Qiangen; Li, Xilin; Li, Dongying; Mei, Nan; Ning, Baitang; Puig, Montserrat; Ren, Zhen; Tolleson, William H; Guo, Lei
细胞生物学
毒理研究
发表日期：2021
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Corrigendum to: "Development and Application of TK6-derived Cells Expressing Human Cytochrome P450s for Genotoxicity Testing"

更正： “用于基因毒性测试的表达人类细胞色素P450的TK6衍生细胞的开发和应用”

期刊:Toxicological Sciences
影响因子:4.1
doi:10.1093/toxsci/kfaa100
Li, Xilin; Chen, Si; Guo, Xiaoqing; Wu, Qiangen; Seo, Ji-Eun; Guo, Lei; Manjanatha, Mugimane G; Zhou, Tong; Witt, Kristine L; Mei, Nan
细胞生物学
毒理研究
Human
发表日期：2020
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Development and Application of TK6-derived Cells Expressing Human Cytochrome P450s for Genotoxicity Testing

开发和应用表达人细胞色素P450的TK6衍生细胞进行基因毒性测试

期刊:Toxicological Sciences
影响因子:4.1
doi:10.1093/toxsci/kfaa035
Li, Xilin; Chen, Si; Guo, Xiaoqing; Wu, Qiangen; Seo, Ji-Eun; Guo, Lei; Manjanatha, Mugimane G; Zhou, Tong; Witt, Kristine L; Mei, Nan
细胞生物学
毒理研究
Human
发表日期：2020
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Apoptosis contributes to the cytotoxicity induced by amodiaquine and its major metabolite N-desethylamodiaquine in hepatic cells

细胞凋亡是阿莫地喹及其主要代谢产物N-去乙基阿莫地喹在肝细胞中诱导细胞毒性的原因之一。

期刊:Toxicology in Vitro
影响因子:2.7
doi:10.1016/j.tiv.2019.104669
Tang, Yangshun; Wu, Qiangen; Beland, Frederick A; Chen, Si; Fang, Jia-Long
凋亡
表观遗传
Apoptosis
代谢
细胞生物学
毒理研究
发表日期：2020
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Comparative Genotoxicity of TEMPO and 3 of Its Derivatives in Mouse Lymphoma Cells

TEMPO及其3种衍生物在小鼠淋巴瘤细胞中的遗传毒性比较

期刊:Toxicological Sciences
影响因子:4.1
doi:10.1093/toxsci/kfy022
Guo, Xiaoqing; Seo, Ji-Eun; Bryce, Steven M; Tan, Jenna A; Wu, Qiangen; Dial, Stacey L; Moore, Martha M; Mei, Nan
Mouse
细胞生物学
毒理研究
淋巴瘤
发表日期：2018
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The role of CYP 3A4 and 1A1 in amiodarone-induced hepatocellular toxicity

CYP 3A4 和 1A1 在胺碘酮诱导的肝细胞毒性中的作用

期刊:Toxicology Letters
影响因子:2.9
doi:10.1016/j.toxlet.2016.04.016
Wu, Qiangen; Ning, Baitang; Xuan, Jiekun; Ren, Zhen; Guo, Lei; Bryant, Matthew S
细胞生物学
毒理研究
发表日期：2016
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