Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2
迭代计算设计和晶体学筛选鉴定出靶向SARS-CoV-2 Nsp3宏结构域的有效抑制剂
期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2212931120
Gahbauer, Stefan; Correy, Galen J; Schuller, Marion; Ferla, Matteo P; Doruk, Yagmur Umay; Rachman, Moira; Wu, Taiasean; Diolaiti, Morgan; Wang, Siyi; Neitz, R Jeffrey; Fearon, Daren; Radchenko, Dmytro S; Moroz, Yurii S; Irwin, John J; Renslo, Adam R; Taylor, Jenny C; Gestwicki, Jason E; von Delft, Frank; Ashworth, Alan; Ahel, Ivan; Shoichet, Brian K; Fraser, James S