Discovery of Natural Resorcylic Acid Lactones as Novel Potent Copper Ionophores Covalently Targeting PRDX1 to Induce Cuproptosis for Triple-Negative Breast Cancer Therapy.
发现天然间苯二酚酸内酯作为新型强效铜离子载体，通过共价靶向 PRDX1 诱导铜凋亡，用于三阴性乳腺癌治疗
期刊:ACS Central Science
影响因子:10.4
doi:10.1021/acscentsci.4c02188
Feng Li, Wu Ti-Zhi, Guo Xin-Rui, Wang Yun-Jie, Wang Xin-Jia, Liu Shao-Xuan, Zhang Rui, Ma Yi, Tan Ning-Hua, Bian Jin-Lei, Wang Zhe
